Literature DB >> 32814092

FKBP-related ncRNA-mRNA axis in breast cancer.

Hanchu Xiong1, Zihan Chen2, Weijun Chen3, Qiang Li3, Baihua Lin3, Yongshi Jia4.   

Abstract

Breast cancer (BC) is a disease with morbidity ranking the first of women worldwidely. In current study, 11 DE-miRNAs, consisting of four FKBP4 related DE-miRNAs and seven FKBP5 related DE-miRNAs, were screened. Four hundred and eighty two predicted lncRNAs were found for DE-miRNAs. Then, expression and prognostic results of nine of top 20 lncRNAs of BC were significantly identified. LINC00662 and LINC00963 expression were significantly associated with patients' overall survival (OS). Then, nine potential upstream transcription factors were identified in motifs of DE-miRNAs. Three hundred and twenty target genes were identified for GO annotation and KEGG pathway analysis, which were mainly enriched in cysteine-type endopeptidase activity involved in apoptotic process. Construction and analysis in PPI network showed that RAB7A was selected as a hub gene with the topest connectivity scores. Differential expression analysis of nine in top ten hub genes of BC were significantly identified. RAB7A and ARRB1 expression were significantly related with BC patients' OS.
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Bioinformatic analysis; Breast cancer; FK506-binding protein; Long noncoding RNA; microRNA

Year:  2020        PMID： 32814092     DOI： 10.1016/j.ygeno.2020.08.017

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  7 in total

1.  Integrated bioinformatics and statistical approaches to explore molecular biomarkers for breast cancer diagnosis, prognosis and therapies.

Authors:  Md Shahin Alam; Adiba Sultana; Md Selim Reza; Md Amanullah; Syed Rashel Kabir; Md Nurul Haque Mollah
Journal:  PLoS One       Date:  2022-05-26       Impact factor: 3.752

2.  Naringenin Regulates FKBP4/NR3C1/NRF2 Axis in Autophagy and Proliferation of Breast Cancer and Differentiation and Maturation of Dendritic Cell.

Authors:  Hanchu Xiong; Zihan Chen; Baihua Lin; Bojian Xie; Xiaozhen Liu; Cong Chen; Zhaoqing Li; Yunlu Jia; Zhuazhua Wu; Min Yang; Yongshi Jia; Linbo Wang; Jichun Zhou; Xuli Meng
Journal:  Front Immunol       Date:  2022-01-11       Impact factor: 7.561

Review 3.  Long Noncoding RNAs Regulate the Radioresistance of Breast Cancer.

Authors:  Zhifeng Li; Fujin Wang; Yinxing Zhu; Ting Guo; Mei Lin
Journal:  Anal Cell Pathol (Amst)       Date:  2021-09-20       Impact factor: 2.916

4.  Role of ARRB1 in prognosis and immunotherapy: A Pan-Cancer analysis.

Authors:  Yingquan Ye; Haili Jiang; Yue Wu; Gaoxiang Wang; Yi Huang; Weijie Sun; Mei Zhang
Journal:  Front Mol Biosci       Date:  2022-09-23

5.  Mendelian randomization analysis identified genes pleiotropically associated with central corneal thickness.

Authors:  Zhikun Yang; Jingyun Yang; Di Liu; Weihong Yu
Journal:  BMC Genomics       Date:  2021-07-07       Impact factor: 3.969

6.  Comprehensive analysis of FKBP4/NR3C1/TMEM173 signaling pathway in triple-negative breast cancer cell and dendritic cell among tumor microenvironment.

Authors:  Hanchu Xiong; Zihan Chen; Baihua Lin; Weijun Chen; Qiang Li; Yucheng Li; Min Fang; Ying Wang; Haibo Zhang; Yanwei Lu; Aihong Bi; Shuqiang Wu; Yongshi Jia; Xiao Wang
Journal:  Mol Ther Oncolytics       Date:  2022-01-04       Impact factor: 7.200

Review 7.  Long Non-Coding RNAs at the Chromosomal Risk Loci Identified by Prostate and Breast Cancer GWAS.

Authors:  Panchadsaram Janaththani; Sri Lakshmi Srinivasan; Jyotsna Batra
Journal:  Genes (Basel)       Date:  2021-12-20       Impact factor: 4.096
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.