Literature DB >> 3281388

Prospects for a virus non-structural protein as a subunit vaccine.

C A Gibson1, J J Schlesinger, A D Barrett.   

Abstract

The design of contemporary vaccines to date has been dependent upon our understanding of the process of stimulation of protective immunity by virion proteins. However, studies with the flaviviruses have demonstrated that protective immunity can be elicited by a non-structural protein, NS1. Surprisingly, immunity to infection is stimulated in the absence of neutralizing antibodies. The information concerning NS1-induced immunity is described and is discussed with relevance to the role of the protein in immunity and vaccine development, against flavivirus diseases. The possibility exists that the phenomenon of non-structural protein induced immunity is applicable to the prophylaxis of other virus diseases.

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Year:  1988        PMID： 3281388     DOI： 10.1016/0264-410x(88)90004-7

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  12 in total

1.  Antibodies against West Nile Virus nonstructural protein NS1 prevent lethal infection through Fc gamma receptor-dependent and -independent mechanisms.

Authors:  Kyung Min Chung; Grant E Nybakken; Bruce S Thompson; Michael J Engle; Anantha Marri; Daved H Fremont; Michael S Diamond
Journal:  J Virol       Date:  2006-02       Impact factor: 5.103

Review 2.  Molecular mechanisms of antibody-mediated neutralisation of flavivirus infection.

Authors:  Theodore C Pierson; Michael S Diamond
Journal:  Expert Rev Mol Med       Date:  2008-05-12       Impact factor: 5.600

3.  A novel complex formed between the flavivirus E and NS1 proteins: analysis of its structure and function.

Authors:  B J Blitvich; J S Mackenzie; R J Coelen; M J Howard; R A Hall
Journal:  Arch Virol       Date:  1995       Impact factor: 2.574

4.  Neutralizing antibodies protect against lethal flavivirus challenge but allow for the development of active humoral immunity to a nonstructural virus protein.

Authors:  T R Kreil; E Maier; S Fraiss; M M Eibl
Journal:  J Virol       Date:  1998-04       Impact factor: 5.103

5.  Lymphocyte proliferative responses to separated bovine herpesvirus 1 proteins in immune cattle.

Authors:  D L Hutchings; S van Drunen Littel-van den Hurk; L A Babiuk
Journal:  J Virol       Date:  1990-10       Impact factor: 5.103

6.  DNA immunization with Japanese encephalitis virus nonstructural protein NS1 elicits protective immunity in mice.

Authors:  Y L Lin; L K Chen; C L Liao; C T Yeh; S H Ma; J L Chen; Y L Huang; S S Chen; H Y Chiang
Journal:  J Virol       Date:  1998-01       Impact factor: 5.103

7.  Nucleotide sequence and mutation rate of the H strain of hepatitis C virus.

Authors:  N Ogata; H J Alter; R H Miller; R H Purcell
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-15       Impact factor: 11.205

8.  Antibody recognition of cell surface-associated NS1 triggers Fc-gamma receptor-mediated phagocytosis and clearance of West Nile Virus-infected cells.

Authors:  Kyung Min Chung; Bruce S Thompson; Daved H Fremont; Michael S Diamond
Journal:  J Virol       Date:  2007-06-20       Impact factor: 5.103

9.  Preparation of Japanese encephalitis virus nonstructural protein NS1 obtained from culture fluid of JEV-infected Vero cells.

Authors:  T Lee; K Watanabe; C Aizawa; A Nomoto; H Hashimoto
Journal:  Arch Virol       Date:  1991       Impact factor: 2.574

10.  Immunoinformatics approach for multi-epitope vaccine design against structural proteins and ORF1a polyprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

Authors:  Khalid Mohamed Adam
Journal:  Trop Dis Travel Med Vaccines       Date:  2021-07-08
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