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Literature DB >> 32813614

Regulation of human telomerase RNA biogenesis and localization.

Abstract

Maintenance of telomeres is essential for genome integrity and replicative capacity in eukaryotic cells. Telomerase, the ribonucleoprotein complex that catalyses telomere synthesis is minimally composed of a reverse transcriptase and an RNA component. The sequence and structural domains of human telomerase RNA (hTR) have been extensively characterized, while the regulation of hTR transcription, maturation, and localization, is not fully understood. Here, we provide an up-to-date review of hTR, with an emphasis on current breakthroughs uncovering the mechanisms of hTR maturation and localization.

Entities: Gene Species

Keywords: H/ACA box; PARN; RNA localization; TCAB1; Telomere; ageing; cap hypermethylation; exosome; human telomerase RNA; telomerase

Year: 2020 PMID： 32813614 PMCID： PMC7954027 DOI： 10.1080/15476286.2020.1809196

Source DB: PubMed Journal: RNA Biol ISSN： 1547-6286 Impact factor: 4.652

130 in total

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Journal: Proc Natl Acad Sci U S A Date: 2004-10-04 Impact factor: 11.205

2. Characterization of a short isoform of human Tgs1 hypermethylase associating with small nucleolar ribonucleoprotein core proteins and produced by limited proteolytic processing.

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Journal: J Biol Chem Date: 2007-11-26 Impact factor: 5.157

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Journal: Cell Rep Date: 2018-09-04 Impact factor: 9.423

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Journal: Mol Cell Biol Date: 2001-03 Impact factor: 4.272

Review 5. Transcription regulation by the Mediator complex.

Authors: Julie Soutourina
Journal: Nat Rev Mol Cell Biol Date: 2017-12-06 Impact factor: 94.444

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Journal: Int J Clin Exp Med Date: 2011-09-15

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Journal: Nat Rev Mol Cell Biol Date: 2007-03 Impact factor: 94.444

8. The human nuclear exosome targeting complex is loaded onto newly synthesized RNA to direct early ribonucleolysis.

Authors: Michal Lubas; Peter Refsing Andersen; Aleks Schein; Andrzej Dziembowski; Grzegorz Kudla; Torben Heick Jensen
Journal: Cell Rep Date: 2015-01-08 Impact factor: 9.423

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Authors: Deanna Elise MacNeil; Hélène Jeanne Bensoussan; Chantal Autexier
Journal: Genes (Basel) Date: 2016-09-14 Impact factor: 4.096

10. Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies.

Authors: Jacob M Vogan; Xiaozhu Zhang; Daniel T Youmans; Samuel G Regalado; Joshua Z Johnson; Dirk Hockemeyer; Kathleen Collins
Journal: Elife Date: 2016-08-15 Impact factor: 8.140

4 in total

Review 1. Genetics of human telomere biology disorders.

Authors: Patrick Revy; Caroline Kannengiesser; Alison A Bertuch
Journal: Nat Rev Genet Date: 2022-09-23 Impact factor: 59.581

Review 2. Dyskerin: an essential pseudouridine synthase with multifaceted roles in ribosome biogenesis, splicing, and telomere maintenance.

Authors: Alexandre Garus; Chantal Autexier
Journal: RNA Date: 2021-09-23 Impact factor: 4.942

3. Analysis of Telomere Maintenance Related Genes Reveals NOP10 as a New Metastatic-Risk Marker in Pheochromocytoma/Paraganglioma.

Authors: María Monteagudo; Paula Martínez; Luis J Leandro-García; Ángel M Martínez-Montes; Bruna Calsina; Marta Pulgarín-Alfaro; Alberto Díaz-Talavera; Sara Mellid; Rocío Letón; Eduardo Gil; Manuel Pérez-Martínez; Diego Megías; Raúl Torres-Ruiz; Sandra Rodriguez-Perales; Patricia González; Eduardo Caleiras; Scherezade Jiménez-Villa; Giovanna Roncador; Cristina Álvarez-Escolá; Rita M Regojo; María Calatayud; Sonsoles Guadalix; Maria Currás-Freixes; Elena Rapizzi; Letizia Canu; Svenja Nölting; Hanna Remde; Martin Fassnacht; Nicole Bechmann; Graeme Eisenhofer; Massimo Mannelli; Felix Beuschlein; Marcus Quinkler; Cristina Rodríguez-Antona; Alberto Cascón; María A Blasco; Cristina Montero-Conde; Mercedes Robledo
Journal: Cancers (Basel) Date: 2021-09-23 Impact factor: 6.575

Review 4. How Structural Features Define Biogenesis and Function of Human Telomerase RNA Primary Transcript.

Authors: Maria Rubtsova; Olga Dontsova
Journal: Biomedicines Date: 2022-07-08

4 in total