Graziano Onder1, Luigi Palmieri1, Nicola Vanacore2, Marina Giuliano3, Silvio Brusaferro4. 1. Department of Cardiovascular, Endocrine-metabolic Diseases and Aging, Istituto Superiore di Sanità, Rome, Italy. 2. National Center for Disease Prevention and Health Promotion, Istituto Superiore di Sanità, Rome, Italy. 3. National Center for Global Health, Istituto Superiore di Sanità, Rome, Italy. 4. Office of the President, Istituto Superiore di Sanità, Rome, Italy.
Abstract
OBJECTIVE: This study aimed to assess the impact of obesity on nonrespiratory complications in patients dying with coronavirus disease (COVID-19). METHODS: Medical charts of 3,694 of patients dying with COVID-19 in Italy were reviewed to extract information on demographics, preexisting comorbidities, and in-hospital complications leading to death. Multivariate logistic regressions were performed to assess the association of obesity with nonrespiratory complications. These analyses were adjusted for age, gender, and number of preexisting comorbidities. RESULTS: Obesity was present in 411/3,694 (11.1%) patients dying with COVID-19. Obesity was significantly associated with increased probability of experiencing acute renal failure (adjusted odds ratio [OR], 1.33; 95% CI: 1.04-1.71) and shock (adjusted OR, 1.54; 95% CI: 1.19-1.99). The associations of obesity with acute renal failure and shock were stronger in patients aged < 60 years (adjusted OR, 2.00; 95% CI: 1.09-3.67 and OR, 2.37; 95% CI 1.29-4.36) than in those aged 60 years or older (adjusted OR, 1.20; 95% CI: 0.90-1.60 and OR, 1.22; 95% CI: 0.91-1.65). CONCLUSIONS: In patients dying with COVID-19 in Italy, obesity is associated with an increased probability of nonrespiratory complications, particularly shock and acute renal failure. These associations seem stronger in younger than in older adults. Strategies should be put in place in patients with COVID-19 with obesity to prevent these complications.
OBJECTIVE: This study aimed to assess the impact of obesity on nonrespiratory complications in patients dying with coronavirus disease (COVID-19). METHODS: Medical charts of 3,694 of patients dying with COVID-19 in Italy were reviewed to extract information on demographics, preexisting comorbidities, and in-hospital complications leading to death. Multivariate logistic regressions were performed to assess the association of obesity with nonrespiratory complications. These analyses were adjusted for age, gender, and number of preexisting comorbidities. RESULTS:Obesity was present in 411/3,694 (11.1%) patients dying with COVID-19. Obesity was significantly associated with increased probability of experiencing acute renal failure (adjusted odds ratio [OR], 1.33; 95% CI: 1.04-1.71) and shock (adjusted OR, 1.54; 95% CI: 1.19-1.99). The associations of obesity with acute renal failure and shock were stronger in patients aged < 60 years (adjusted OR, 2.00; 95% CI: 1.09-3.67 and OR, 2.37; 95% CI 1.29-4.36) than in those aged 60 years or older (adjusted OR, 1.20; 95% CI: 0.90-1.60 and OR, 1.22; 95% CI: 0.91-1.65). CONCLUSIONS: In patients dying with COVID-19 in Italy, obesity is associated with an increased probability of nonrespiratory complications, particularly shock and acute renal failure. These associations seem stronger in younger than in older adults. Strategies should be put in place in patients with COVID-19 with obesity to prevent these complications.
Authors: Hassan Ashktorab; Antonio Pizuomo; Nora Alma Fierro González; Edgar Daniel Copado Villagrana; María Evangelina Herrera-Solís; Graciela Cardenas; Daniela Zavala-Alvarez; Gholamreza Oskrochi; Eyitope Awoyemi; Folake Adeleye; Maryam Mehdipour Dalivand; Adeyinka O Laiyemo; Edward E Lee; Farshad Aduli; Zaki A Sherif; Hassan Brim Journal: Res Sq Date: 2021-01-08
Authors: Antonis S Manolis; Antonis A Manolis; Theodora A Manolis; Naomi E Apostolaki; Helen Melita Journal: Obes Res Clin Pract Date: 2021-11-03 Impact factor: 2.288
Authors: Charlotte Steenblock; Mohamed Hassanein; Emran G Khan; Mohamad Yaman; Margrit Kamel; Mahmoud Barbir; Dietrich E Lorke; Dean Everett; Saqipi Bejtullah; Tobias Lohmann; Uwe Lindner; Ermal Tahirukaj; Feras Jassim Jirjees; Sameh S M Soliman; Friederike Quitter; Stefan R Bornstein Journal: Horm Metab Res Date: 2022-06-20 Impact factor: 2.788