Manuel Martínez-Sellés1, M Esther Martínez-Larrú2, Martin Ibarrola3, Alba Santos4, Pablo Díez-Villanueva5, Antoni Bayés-Genis6, Adrian Baranchuk7, Antonio Bayés-de-Luna8, Roberto Elosua9. 1. Servicio de Cardiología, Hospital General Universitario Gregorio Marañón, Universidad Europea, Universidad Complutense, Madrid, Spain; CIBERCV, Madrid, Spain. Electronic address: mmselles@secardiologia.es. 2. Departamento de Urgencias, Hospital General Universitario Gregorio Marañón, Madrid, Spain. 3. Centro Cardiovascular BV, Buenos Aires, Argentina. 4. Servicio de Cardiología, Hospital Universitario Vall d'Hebron, Barcelona, Spain. 5. Servicio de Cardiología, Hospital Universitario de la Princesa, Madrid, Spain. 6. CIBERCV, Madrid, Spain; Institut del Cor, Hospital Universitari Germans Trias i Pujol, Badalona, Universidad Autónoma de Barcelona, Spain. 7. Queens University, Kingston, Ontario, Canada. 8. Fundación de Investigación Cardiovascular, ICCC- Institute de Investigación, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. 9. CIBERCV, Madrid, Spain; Instituto Hospital del Mar de Investigaciones Médicas (IMIM), Barcelona, Facultad de Medicina, Universidad de Vic-Universidad Central de Cataluña, Vic, Spain.
Abstract
BACKGROUND: An association between interatrial block (IAB) (P wave duration ≥120 ms) and dementia has been suggested. Our objective was to assess the association of IAB with cognitive impairment (CI). METHODS: The prospective BAYES registry included 552 patients ≥70 years with structural heart disease without documented atrial fibrillation. Cognitive ability was assessed at baseline and every 6 months with the Pfeiffer test. The median follow-up was 22 months. RESULTS: Thirty patients (5.4%) had baseline CI, 20 patients with mild CI and 10 with moderate CI. Compared to patients without CI, patients with CI had higher mean age (80.4 ± 6.5 vs. 76.8 ± 5.4 years) and higher prevalence of advanced IAB (with biphasic P-wave ± in inferior leads) (14 [46.7%] vs. 122 [23.4%], p < .01). The prevalence of baseline CI was 2.7% in normal P-wave, 5.1% in partial IAB, and 10.3% in advanced IAB, p < .001. Advanced IAB was independently associated with baseline CI (odds ratio 4.9, 95% confidence interval 1.4-16.5), this was not the case with partial IAB (odds ratio 2.1, 95% confidence interval 0.5-7.4). The independent association with CI at follow-up existed both for partial IAB (hazard ratio 1.98, 95% confidence interval 1.18-3.33) and advanced IAB (hazard ratio 2.04, 95% confidence interval 1.19-3.51). CONCLUSION: In patients aged 70 years or more with structural heart disease who are in sinus rhythm advanced IAB is associated with baseline CI. There is also an association of partial and advanced IAB with CI during follow-up.
BACKGROUND: An association between interatrial block (IAB) (P wave duration ≥120 ms) and dementia has been suggested. Our objective was to assess the association of IAB with cognitive impairment (CI). METHODS: The prospective BAYES registry included 552 patients ≥70 years with structural heart disease without documented atrial fibrillation. Cognitive ability was assessed at baseline and every 6 months with the Pfeiffer test. The median follow-up was 22 months. RESULTS: Thirty patients (5.4%) had baseline CI, 20 patients with mild CI and 10 with moderate CI. Compared to patients without CI, patients with CI had higher mean age (80.4 ± 6.5 vs. 76.8 ± 5.4 years) and higher prevalence of advanced IAB (with biphasic P-wave ± in inferior leads) (14 [46.7%] vs. 122 [23.4%], p < .01). The prevalence of baseline CI was 2.7% in normal P-wave, 5.1% in partial IAB, and 10.3% in advanced IAB, p < .001. Advanced IAB was independently associated with baseline CI (odds ratio 4.9, 95% confidence interval 1.4-16.5), this was not the case with partial IAB (odds ratio 2.1, 95% confidence interval 0.5-7.4). The independent association with CI at follow-up existed both for partial IAB (hazard ratio 1.98, 95% confidence interval 1.18-3.33) and advanced IAB (hazard ratio 2.04, 95% confidence interval 1.19-3.51). CONCLUSION: In patients aged 70 years or more with structural heart disease who are in sinus rhythm advanced IAB is associated with baseline CI. There is also an association of partial and advanced IAB with CI during follow-up.
Authors: Wendy Wang; Michael J Zhang; Riccardo M Inciardi; Faye L Norby; Michelle C Johansen; Romil Parikh; Jeremy R Van't Hof; Alvaro Alonso; Elsayed Z Soliman; Thomas H Mosley; Rebecca F Gottesman; Amil M Shah; Scott D Solomon; Lin Yee Chen Journal: JAMA Date: 2022-03-22 Impact factor: 157.335
Authors: Lin Yee Chen; Antonio Luiz Pinho Ribeiro; Pyotr G Platonov; Iwona Cygankiewicz; Elsayed Z Soliman; Bulent Gorenek; Takanori Ikeda; Vassilios P Vassilikos; Jonathan S Steinberg; Niraj Varma; Antoni Bayés-de-Luna; Adrian Baranchuk Journal: Circ Arrhythm Electrophysiol Date: 2022-03-25
Authors: Andrea Saglietto; Andrea Ballatore; Henri Xhakupi; Gaetano Maria De Ferrari; Matteo Anselmino Journal: Medicina (Kaunas) Date: 2022-03-01 Impact factor: 2.430