Literature DB >> 32810525

NRF2 in human neoplasm: Cancer biology and potential therapeutic target.

Yang Liu1, Fengchao Lang2, Chunzhang Yang3.   

Abstract

Nuclear factor-erythroid 2-related factor 2 (NRF2) is a master regulator of a series of cytoprotective genes, which protects cells from stress conditions such as reactive oxygen species (ROS) and electrophiles. Besides its pivotal role in cellular physiology and stress response, several recent advances revealed that NRF2-governed pathways are extensively exploited in cancer cells, and play critical roles in granting growth advantage, supporting cancer metabolism, and promoting malignant transformation. In the present review, we focus on the regulatory mechanisms of NRF2 and its roles in cancer biology. We also discuss the value of targeting NRF2-associated pathways as a means of developing future cancer therapeutics. Published by Elsevier Inc.

Entities:  

Keywords:  Antioxidant pathway; Cancer; Glutathione; KEAP1; NRF2; Therapy resistance

Year:  2020        PMID： 32810525     DOI： 10.1016/j.pharmthera.2020.107664

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  8 in total

Review 1.  Cancer stem cells: advances in biology and clinical translation-a Keystone Symposia report.

Authors:  Jennifer Cable; Duanqing Pei; Lola M Reid; Xin Wei Wang; Sonam Bhatia; Panagiotis Karras; Jan Joseph Melenhorst; Markus Grompe; Justin D Lathia; Erwei Song; Calvin J Kuo; Ning Zhang; Richard M White; Stephanie Ky Ma; Lichun Ma; Y Rebecca Chin; Michael M Shen; Irene Oi Lin Ng; Klaus H Kaestner; Lei Zhou; Shaheen Sikandar; Clemens A Schmitt; Wei Guo; Carmen Chak-Lui Wong; Junfang Ji; Dean G Tang; Anna Dubrovska; Chunzhang Yang; Wolf R Wiedemeyer; Irving L Weissman
Journal:  Ann N Y Acad Sci       Date:  2021-11-30       Impact factor: 6.499

2.  Exogenous Antioxidants Impact on UV-Induced Changes in Membrane Phospholipids and the Effectiveness of the Endocannabinoid System in Human Skin Cells.

Authors:  Agnieszka Gęgotek; Anna Jastrząb; Marta Dobrzyńska; Michał Biernacki; Elżbieta Skrzydlewska
Journal:  Antioxidants (Basel)       Date:  2021-08-06

Review 3.  The Role of Nrf2 in Hearing Loss.

Authors:  Dafei Li; Haiyan Zhao; Zhong-Kai Cui; Guangyong Tian
Journal:  Front Pharmacol       Date:  2021-04-12       Impact factor: 5.810

4.  Machine Learning Identifies Pan-Cancer Landscape of Nrf2 Oxidative Stress Response Pathway-Related Genes.

Authors:  Na Li; Xianquan Zhan
Journal:  Oxid Med Cell Longev       Date:  2022-02-17       Impact factor: 6.543

Review 5.  Research Progress on the Regulation Mechanism of Key Signal Pathways Affecting the Prognosis of Glioma.

Authors:  Hao Wu; Min Wei; Yuping Li; Qiang Ma; Hengzhu Zhang
Journal:  Front Mol Neurosci       Date:  2022-07-22       Impact factor: 6.261

6.  Involvement of Mitochondrial Mechanisms in the Cytostatic Effect of Desethylamiodarone in B16F10 Melanoma Cells.

Authors:  Fadi H J Ramadan; Aliz Szabo; Dominika Kovacs; Aniko Takatsy; Rita Bognar; Ferenc Gallyas; Zita Bognar
Journal:  Int J Mol Sci       Date:  2020-10-05       Impact factor: 5.923

Review 7.  Kidney cancer biomarkers and targets for therapeutics: survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell carcinoma.

Authors:  Ieman A M Aljahdali; Renyuan Zhang; Fengzhi Li; Kent L Nastiuk; John J Krolewski; Xiang Ling
Journal:  J Exp Clin Cancer Res       Date:  2021-08-12

Review 8.  Genotoxic therapy and resistance mechanism in gliomas.

Authors:  Fengchao Lang; Yang Liu; Fu-Ju Chou; Chunzhang Yang
Journal:  Pharmacol Ther       Date:  2021-06-23       Impact factor: 12.310
  8 in total

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