Marta Waliszewska-Prosół1, Agata Sebastian2, Piotr Wiland2, Sławomir Budrewicz3, Edyta Dziadkowiak3, Maria Ejma3. 1. Department of Neurology, Wrocław Medical University, Borowska 213, 50-556, Wrocław, Poland. marta.waliszewska@gmail.com. 2. Department of Rheumatology and Internal Diseases, Wrocław Medical University, Borowska 213, 50-556, Wrocław, Polska. 3. Department of Neurology, Wrocław Medical University, Borowska 213, 50-556, Wrocław, Poland.
Abstract
OBJECTIVES: Primary Sjögren's syndrome (pSS) is an autoimmune, multisystem exocrinopathy characterized by dysfunction of the exocrine glands. Central nervous system (CNS) involvement is estimated to be present in 10-60% patients with pSS. The present study aimed to evaluate brainstem auditory evoked potentials (BAEP) in pSS patients without central nervous system involvement, and without otolaryngological abnormalities. METHOD: Thirty-six pSS patients (35 women, 1 man, mean age 48 years old) and 40 healthy volunteers were investigated. BAEP, brain imaging, laboratory parameters, and clinical neurological and otolaryngological examinations were performed. RESULTS: Abnormal BAEP were recorded in 16.7% patients. The mean wave BAEP I and V latency and mean wave III-V and I-V interpeak latencies were significantly longer in pSS patients than the controls. There were no statistically significant correlations between BAEP parameters and laboratory tests. None of the patients was found having the abnormalities on brain imaging. CONCLUSIONS: This study confirms that in pSS patients without clinical central nervous system impairment, auditory pathway disturbances could be found. Disorders of brain bioelectrical activity may be a consequence of ongoing autoimmune process. Key Points • BAEP abnormalities confirmed the clinically observed involvement of the central nervous system in patients with pSS. • Brain bioelectrical activity dysfunctions in pSS patients may be a consequence of ongoing inflammatory and/or immunological processes.
OBJECTIVES: Primary Sjögren's syndrome (pSS) is an autoimmune, multisystem exocrinopathy characterized by dysfunction of the exocrine glands. Central nervous system (CNS) involvement is estimated to be present in 10-60% patients with pSS. The present study aimed to evaluate brainstem auditory evoked potentials (BAEP) in pSS patients without central nervous system involvement, and without otolaryngological abnormalities. METHOD: Thirty-six pSS patients (35 women, 1 man, mean age 48 years old) and 40 healthy volunteers were investigated. BAEP, brain imaging, laboratory parameters, and clinical neurological and otolaryngological examinations were performed. RESULTS: Abnormal BAEP were recorded in 16.7% patients. The mean wave BAEP I and V latency and mean wave III-V and I-V interpeak latencies were significantly longer in pSS patients than the controls. There were no statistically significant correlations between BAEP parameters and laboratory tests. None of the patients was found having the abnormalities on brain imaging. CONCLUSIONS: This study confirms that in pSS patients without clinical central nervous system impairment, auditory pathway disturbances could be found. Disorders of brain bioelectrical activity may be a consequence of ongoing autoimmune process. Key Points • BAEP abnormalities confirmed the clinically observed involvement of the central nervous system in patients with pSS. • Brain bioelectrical activity dysfunctions in pSS patients may be a consequence of ongoing inflammatory and/or immunological processes.
Authors: E Dziadkowiak; A Sebastian; P Wiland; M Waliszewska-Prosół; M Wieczorek; M Zagrajek; M Ejma Journal: Scand J Rheumatol Date: 2015-08-14 Impact factor: 3.641
Authors: Raphaèle Seror; Simon J Bowman; Pilar Brito-Zeron; Elke Theander; Hendrika Bootsma; Athanasios Tzioufas; Jacques-Eric Gottenberg; Manel Ramos-Casals; Thomas Dörner; Philippe Ravaud; Claudio Vitali; Xavier Mariette; Karsten Asmussen; Soren Jacobsen; Elena Bartoloni; Roberto Gerli; Johannes Wj Bijlsma; Aike A Kruize; Stefano Bombardieri; Arthur Bookman; Cees Kallenberg; Petra Meiners; Johan G Brun; Roland Jonsson; Roberto Caporali; Steven Carsons; Salvatore De Vita; Nicoletta Del Papa; Valerie Devauchelle; Alain Saraux; Anne-Laure Fauchais; Jean Sibilia; Eric Hachulla; Gabor Illei; David Isenberg; Adrian Jones; Menelaos Manoussakis; Thomas Mandl; Lennart Jacobsson; Frederic Demoulins; Carlomaurizio Montecucco; Wan-Fai Ng; Sumusu Nishiyama; Roald Omdal; Ann Parke; Sonja Praprotnik; Matjia Tomsic; Elizabeth Price; Hal Scofield; Kathy L Sivils; Josef Smolen; Roser Solans Laqué; Serge Steinfeld; Nurhan Sutcliffe; Takayuki Sumida; Guido Valesini; Valeria Valim; Frederick B Vivino; Cristina Vollenweider Journal: RMD Open Date: 2015-02-20