Karla Therese L Sy1,2, Nel Jason L Haw3, Jhanna Uy3,4. 1. Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. 2. Department of Global Health, Boston University School of Public Health, Boston, MA, USA. 3. Health Sciences Program, School of Science and Engineering, Ateneo de Manila University, Manila, Philippines. 4. Philippine Institute for Development Studies, Manila, Philippines.
Abstract
BACKGROUND: There is a growing literature on the association of SARS-CoV-2 and other chronic conditions, such as noncommunicable diseases. However, little is known about the impact of coinfection with tuberculosis. We aimed to compare the risk of death and recovery, as well as time-to-death and time-to-recovery, in COVID-19 patients with and without tuberculosis. METHODS: We created a 4:1 propensity score matched sample of COVID-19 patients without and with tuberculosis, using COVID-19 surveillance data in the Philippines. We conducted a longitudinal cohort analysis of matched COVID-19 patients as of May 17, 2020, following them until June 15, 2020. The primary analysis estimated the risk ratios of death and recovery in patients with and without tuberculosis. Kaplan-Meier curves described time-to-death and time-to-recovery stratified by tuberculosis status, and differences in survival were assessed using the Wilcoxon test. RESULTS: The risk of death in COVID-19 patients with tuberculosis was 2.17 times higher than in those without (95% CI: 1.40-3.37). The risk of recovery in COVID-19 patients with tuberculosis was 25% lower than in those without (RR = 0.75,05% CI 0.63-0.91). Similarly, time-to-death was significantly shorter (p = .0031) and time-to-recovery significantly longer in patients with tuberculosis (p = .0046). CONCLUSIONS: Our findings show that coinfection with tuberculosis increased morbidity and mortality in COVID-19 patients. Our findings highlight the need to prioritize routine and testing services for tuberculosis, although health systems are disrupted by the heavy burden of the SARS-CoV-2 pandemic.
BACKGROUND: There is a growing literature on the association of SARS-CoV-2 and other chronic conditions, such as noncommunicable diseases. However, little is known about the impact of coinfection with tuberculosis. We aimed to compare the risk of death and recovery, as well as time-to-death and time-to-recovery, in COVID-19patients with and without tuberculosis. METHODS: We created a 4:1 propensity score matched sample of COVID-19patients without and with tuberculosis, using COVID-19 surveillance data in the Philippines. We conducted a longitudinal cohort analysis of matched COVID-19patients as of May 17, 2020, following them until June 15, 2020. The primary analysis estimated the risk ratios of death and recovery in patients with and without tuberculosis. Kaplan-Meier curves described time-to-death and time-to-recovery stratified by tuberculosis status, and differences in survival were assessed using the Wilcoxon test. RESULTS: The risk of death in COVID-19patients with tuberculosis was 2.17 times higher than in those without (95% CI: 1.40-3.37). The risk of recovery in COVID-19patients with tuberculosis was 25% lower than in those without (RR = 0.75,05% CI 0.63-0.91). Similarly, time-to-death was significantly shorter (p = .0031) and time-to-recovery significantly longer in patients with tuberculosis (p = .0046). CONCLUSIONS: Our findings show that coinfection with tuberculosis increased morbidity and mortality in COVID-19patients. Our findings highlight the need to prioritize routine and testing services for tuberculosis, although health systems are disrupted by the heavy burden of the SARS-CoV-2 pandemic.
Authors: A Trajman; I Felker; L C Alves; I Coutinho; M Osman; S-A Meehan; U B Singh; Y Schwartz Journal: Int J Tuberc Lung Dis Date: 2022-08-01 Impact factor: 3.427
Authors: Jacques L Tamuzi; Birhanu T Ayele; Constance S Shumba; Olatunji O Adetokunboh; Jeannine Uwimana-Nicol; Zelalem T Haile; Joseph Inugu; Peter S Nyasulu Journal: BMC Infect Dis Date: 2020-10-09 Impact factor: 3.090
Authors: S Soltani; S Faramarzi; M Zandi; R Shahbahrami; A Jafarpour; S Akhavan Rezayat; I Pakzad; F Abdi; P Malekifar; R Pakzad Journal: New Microbes New Infect Date: 2021-07-01