| Literature DB >> 32807988 |
Wangxin Guo1,2, Lin Li1,2, Juan He1,2, Zhuang Liu1,2, Ming Han1,2, Fei Li1,2, Xinyi Xia1,2, Xiaoyu Zhang1,2, Yao Zhu3,4, Yu Wei3,4, Yunguang Li1,2, Rebiguli Aji1,2, Hao Dai1,2, Hui Wei1, Chunfeng Li1, Yu Chen5,6,7,8, Luonan Chen9,10,11, Dong Gao12,13,14.
Abstract
The identification of prostate stem/progenitor cells and characterization of the prostate epithelial cell lineage hierarchy are critical for understanding prostate cancer initiation. Here, we characterized 35,129 cells from mouse prostates, and identified a unique luminal cell type (termed type C luminal cell (Luminal-C)) marked by Tacstd2, Ck4 and Psca expression. Luminal-C cells located at the distal prostate invagination tips (termed Dist-Luminal-C) exhibited greater capacity for organoid formation in vitro and prostate epithelial duct regeneration in vivo. Lineage tracing of Luminal-C cells indicated that Dist-Luminal-C cells reconstituted distal prostate luminal lineages through self-renewal and differentiation. Deletion of Pten in Dist-Luminal-C cells resulted in prostatic intraepithelial neoplasia. We further characterized 11,374 human prostate cells and confirmed the existence of h-Luminal-C cells. Our study provides insights into the prostate lineage hierarchy, identifies Dist-Luminal-C cells as the luminal progenitor cell population in invagination tips and suggests one of the potential cellular origins of prostate cancer.Entities:
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Year: 2020 PMID： 32807988 PMCID： PMC8383310 DOI： 10.1038/s41588-020-0642-1
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330