BACKGROUND: Immune modulating therapies are associated with an increased risk of infections and malignancies. This is of particular concern in elderly inflammatory bowel disease patients. This study aims to compare the safety and efficacy of vedolizumab between young and elderly inflammatory bowel disease patients. METHODS: A binational, multicentre, retrospective, cohort study was performed from 2015 to 2019. Patients who underwent treatment with vedolizumab and were followed for at least 14 weeks were studied. They were divided according to age into groups: 40 years or less or 60 years or older. Clinical and endoscopic responses at weeks 14 and 52 and infection development were compared between young and elderly inflammatory bowel disease patient groups. RESULTS: There were 144 patients (82 Crohn's disease and 62 ulcerative colitis) in the elderly cohort and 140 patients (83 Crohn's disease and 57 ulcerative colitis) in the young cohort. The average age was 70.2 ± 7.3 years and 29.6 ± 5.7 years, respectively. Clinical and endoscopic responses were comparable between the groups (week 52 remission of Crohn's disease: 40% vs. 35%, P = 0.7; week 52 remission of ulcerative colitis: 48% vs. 51%, P = 0.84). Previous anti-tumour necrosis factor biological therapy was independently associated with poor clinical remission rates at week 52 (Crohn's disease: odds ratio 0.23, 95% confidence interval 0.06-0.79; P = 0.02 and ulcerative colitis: odds ratio 0.10 95% confidence interval 0.01-0.74; P = 0.024). There were significantly more infections in the elderly cohort (2% vs. 12%, P = 0.002), none of which were fatal. CONCLUSIONS: Vedolizumab is equally effective in elderly and young inflammatory bowel disease patients. The findings of this study demonstrate an increased risk of infections among the elderly treated with vedolizumab, which may be related to their age and underlying diseases.
BACKGROUND: Immune modulating therapies are associated with an increased risk of infections and malignancies. This is of particular concern in elderly inflammatory bowel diseasepatients. This study aims to compare the safety and efficacy of vedolizumab between young and elderly inflammatory bowel diseasepatients. METHODS: A binational, multicentre, retrospective, cohort study was performed from 2015 to 2019. Patients who underwent treatment with vedolizumab and were followed for at least 14 weeks were studied. They were divided according to age into groups: 40 years or less or 60 years or older. Clinical and endoscopic responses at weeks 14 and 52 and infection development were compared between young and elderly inflammatory bowel diseasepatient groups. RESULTS: There were 144 patients (82 Crohn's disease and 62 ulcerative colitis) in the elderly cohort and 140 patients (83 Crohn's disease and 57 ulcerative colitis) in the young cohort. The average age was 70.2 ± 7.3 years and 29.6 ± 5.7 years, respectively. Clinical and endoscopic responses were comparable between the groups (week 52 remission of Crohn's disease: 40% vs. 35%, P = 0.7; week 52 remission of ulcerative colitis: 48% vs. 51%, P = 0.84). Previous anti-tumour necrosis factor biological therapy was independently associated with poor clinical remission rates at week 52 (Crohn's disease: odds ratio 0.23, 95% confidence interval 0.06-0.79; P = 0.02 and ulcerative colitis: odds ratio 0.10 95% confidence interval 0.01-0.74; P = 0.024). There were significantly more infections in the elderly cohort (2% vs. 12%, P = 0.002), none of which were fatal. CONCLUSIONS:Vedolizumab is equally effective in elderly and young inflammatory bowel diseasepatients. The findings of this study demonstrate an increased risk of infections among the elderly treated with vedolizumab, which may be related to their age and underlying diseases.
Authors: Tomer Adar; David Faleck; Saranya Sasidharan; Kelly Cushing; Nienke Z Borren; Niharika Nalagatla; Ryan Ungaro; Wayne Sy; Samuel C Owen; Anish Patel; Benjamin L Cohen; Ashwin N Ananthakrishnan Journal: Aliment Pharmacol Ther Date: 2019-02-17 Impact factor: 8.171
Authors: Hajir Ibraheim; Mark A Samaan; Ashish Srinivasan; Oliver Brain; Jonathan Digby-Bell; Peter M Irving; Irena Norman; Issrah Jawad; Julia Biedermann; Ana Ibarra; Klaartje Bel Kok; Gareth Parkes; Joanna Rimmer; Elisabeta Compot; Miles Parkes; Jonathan Segal; Philip Oppong; Ailsa Hart; Bu'Hussain Hayee; Nick Powell Journal: Ann Gastroenterol Date: 2020-01-07
Authors: Gustavo Drügg Hahn; Jean-Frédéric LeBlanc; Petra Anna Golovics; Panu Wetwittayakhlang; Abdulrahman Qatomah; Anna Wang; Levon Boodaghians; Jeremy Liu Chen Kiow; Maryam Al Ali; Gary Wild; Waqqas Afif; Alain Bitton; Peter Laszlo Lakatos; Talat Bessissow Journal: World J Gastroenterol Date: 2022-09-07 Impact factor: 5.374