| Literature DB >> 32804767 |
Timothée Zaragori1,2, Angelo Castello3, Eric Guedj4,5, Antoine Girard6, Norbert Galldiks7,8,9, Nathalie L Albert10, Egesta Lopci3, Antoine Verger1,2.
Abstract
The aim is to explore the concept of photopenic defects in newly diagnosed glioma patients with the 2 widely used C-MET and F-FDOPA PET amino acid tracers. Thirty-two C-MET and 26 F-FDOPA PET scans with amino acid PET-negative gliomas were selected in this European multicentric study. Of these gliomas, 16 C-MET and 10 F-FDOPA PET scans with photopenic defects were identified, exhibiting lower mean tumor-to-background ratio as compared with isometabolic gliomas (P < 0.001). Gliomas with photopenic defects had no different progression-free survival than isometabolic gliomas in the whole population (P = 0.40), but shorter progression-free survival in the subgroup of World Health Organization grade II IDH-mutant astrocytomas (35 vs 68 months; P = 0.047).Entities:
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Year: 2021 PMID： 32804767 DOI： 10.1097/RLU.0000000000003240
Source DB: PubMed Journal: Clin Nucl Med ISSN： 0363-9762 Impact factor: 7.794