Lian Cheng1, Yuan Le2, Hui Yang3, Xiangyu Zhou4. 1. Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Department of General Surgery (Thyroid Surgery), Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China. 2. Hospital of Traditional Chinese Medicine affiliated to Southwest Medical University, Luzhou, 646000, China. 3. Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Department of General Surgery (Thyroid Surgery), Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China. yh65011@163.com. 4. Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Department of General Surgery (Thyroid Surgery), Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China. Xiangyuzhou971@vip.126.com.
Abstract
INTRODUCTION: The effect of dexamethasone on postoperative pain after thyroid surgery remains controversial. We conduct a systematic review and meta-analysis to explore the influence of dexamethasone versus placebo on postoperative pain after thyroid surgery. METHODS: We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through May 2020 for randomized controlled trials (RCTs) assessing the effect of dexamethasone versus placebo on postoperative pain after thyroid surgery. This meta-analysis is performed using the random-effect model. RESULTS: Eight RCTs involving 734 patients are included in the meta-analysis. Overall, compared with control group for thyroid surgery, dexamethasone shows significantly reduced pain scores (SMD = - 0.82; 95% CI - 1.08 to - 0.56; P < 0.00001), number of required analgesics (OR = 0.18; 95% CI 0.11-0.31; P < 0.00001), analgesic consumption (SMD = - 0.38; 95% CI - 0.63 to - 0.13; P = 0.003), nausea and vomiting (OR = 0.38; 95% CI 0.17-0.86; P = 0.02), as well as rescue antiemetics (OR = 0.40; 95% CI 0.20-0.79; P = 0.008). CONCLUSIONS: Perioperative dexamethasone is effective to reduce the pain, nausea and vomiting after thyroid surgery.
INTRODUCTION: The effect of dexamethasone on postoperative pain after thyroid surgery remains controversial. We conduct a systematic review and meta-analysis to explore the influence of dexamethasone versus placebo on postoperative pain after thyroid surgery. METHODS: We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through May 2020 for randomized controlled trials (RCTs) assessing the effect of dexamethasone versus placebo on postoperative pain after thyroid surgery. This meta-analysis is performed using the random-effect model. RESULTS: Eight RCTs involving 734 patients are included in the meta-analysis. Overall, compared with control group for thyroid surgery, dexamethasone shows significantly reduced pain scores (SMD = - 0.82; 95% CI - 1.08 to - 0.56; P < 0.00001), number of required analgesics (OR = 0.18; 95% CI 0.11-0.31; P < 0.00001), analgesic consumption (SMD = - 0.38; 95% CI - 0.63 to - 0.13; P = 0.003), nausea and vomiting (OR = 0.38; 95% CI 0.17-0.86; P = 0.02), as well as rescue antiemetics (OR = 0.40; 95% CI 0.20-0.79; P = 0.008). CONCLUSIONS: Perioperative dexamethasone is effective to reduce the pain, nausea and vomiting after thyroid surgery.
Entities:
Keywords:
Dexamethasone; Postoperative pain; Randomized controlled trials; Thyroid surgery
Authors: Raheel Ahmad; Mehwish Changeez; Asim Tameez Ud Din; Anum Iftikhar; Hafiz Bilal Ahmad; Ahmed Mujtaba; Jahangir S Khan; Mustafa N Malik Journal: Cureus Date: 2019-05-23