Literature DB >> 32803538

Blood-Brain Barrier (BBB) Permeability and Transport Measurement In Vitro and In Vivo.

Bingmei M Fu1, Zhen Zhao2, Donghui Zhu3.   

Abstract

Quantification of the blood-brain barrier (BBB) permeability and transport in brain tissue is crucial in understanding brain disorders and developing systemic and non-systemic drug delivery strategies to the brain. This chapter summarizes BBB permeability measurement in vitro (Part I) and the in vivo non-invasive methods for quantifying the BBB permeability to solutes and brain tissue transport in rat brain by employing intravital multiphoton microscopy and a curving fitting method by using an unsteady mass transfer mathematical model (Part II).

Entities:  

Keywords:  BBB permeability; BBB transport; Cerebral microvessel; Effective diffusion coefficient; Intravital fluorescence microscopy; Multiphoton microscopy; Non-invasive; Rat brain; Unsteady mass transfer model

Mesh：

Year:  2021        PMID： 32803538      PMCID： PMC7889748          DOI： 10.1007/7651_2020_308

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  30 in total

1.  An intravital microscopy study of radiation-induced changes in permeability and leukocyte-endothelial cell interactions in the microvessels of the rat pia mater and cremaster muscle.

Authors:  M Waleed Gaber; Hong Yuan; John T Killmar; Michael D Naimark; Mohammad F Kiani; Thomas E Merchant
Journal:  Brain Res Brain Res Protoc       Date:  2004-04

Review 2.  Transport Across the Blood-Brain Barrier.

Authors:  Bingmei M Fu
Journal:  Adv Exp Med Biol       Date:  2018       Impact factor: 2.622

3.  Measurement of solute transport across the blood-brain barrier in the perfused guinea pig brain: method and application to N-methyl-alpha-aminoisobutyric acid.

Authors:  B V Zloković; D J Begley; B M Djuricić; D M Mitrovic
Journal:  J Neurochem       Date:  1986-05       Impact factor: 5.372

4.  Variable restriction of albumin diffusion across inflamed cerebral microvessels of the anaesthetized rat.

Authors:  A S Easton; P A Fraser
Journal:  J Physiol       Date:  1994-02-15       Impact factor: 5.182

5.  Electrical resistance of brain microvascular endothelium.

Authors:  C Crone; S P Olesen
Journal:  Brain Res       Date:  1982-06-03       Impact factor: 3.252

6.  Measurements of dog blood-brain transfer constants by ventriculocisternal perfusion.

Authors:  C S Patlak; J D Fenstermacher
Journal:  Am J Physiol       Date:  1975-10

7.  Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice.

Authors:  F Yuan; M Leunig; D A Berk; R K Jain
Journal:  Microvasc Res       Date:  1993-05       Impact factor: 3.514

8.  Quantification of blood-brain barrier solute permeability and brain transport by multiphoton microscopy.

Authors:  Lingyan Shi; Min Zeng; Yi Sun; Bingmei M Fu
Journal:  J Biomech Eng       Date:  2014-03       Impact factor: 2.097

9.  Blood-brain barrier penetration of felbamate.

Authors:  E M Cornford; D Young; J W Paxton; R D Sofia
Journal:  Epilepsia       Date:  1992 Sep-Oct       Impact factor: 5.864

10.  Quantification of transient increase of the blood-brain barrier permeability to macromolecules by optimized focused ultrasound combined with microbubbles.

Authors:  Lingyan Shi; Paolo Palacio-Mancheno; Joseph Badami; Da Wi Shin; Min Zeng; Luis Cardoso; Raymond Tu; Bingmei M Fu
Journal:  Int J Nanomedicine       Date:  2014-09-18
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