Literature DB >> 32802572

Indirect cell death and the LQ model in SBRT and SRS.

Chang W Song1, Stephanie Terezakis1, Bahman Emami2, Robert J Griffin3, Paul W Sperduto4, Mi-Sook Kim5, L Chinsoo Cho1.   

Abstract

High-dose hypofractionated SBRT and SRS indirectly kills substantial fractions of tumor cells via causing vascular damage. The LQ formula may work well for certain clinical cases of SBRT and SRS when the indirect/additional tumor cell death secondary to vascular damage is small. However, when the indirect cell death is extensive, the LQ model will underestimate the clinical outcome of SBRT and SRS.
© 2020 Old City Publishing, Inc.

Entities:  

Keywords:  LQ model; SBRT; SRS; indirect cell death; secondary cell death

Year:  2020        PMID： 32802572      PMCID： PMC7406346     

Source DB:  PubMed          Journal:  J Radiosurg SBRT


  19 in total

1.  A quantitative analysis of the direct and indirect action of X radiation on malignant cells.

Authors:  I LASNITZKI
Journal:  Br J Radiol       Date:  1947-06       Impact factor: 3.039

2.  A hypothesis: indirect cell death in the radiosurgery era.

Authors:  Paul W Sperduto; Chang W Song; John P Kirkpatrick; Eli Glatstein
Journal:  Int J Radiat Oncol Biol Phys       Date:  2015-01-01       Impact factor: 7.038

3.  Is indirect cell death involved in response of tumors to stereotactic radiosurgery and stereotactic body radiation therapy?

Authors:  Chang W Song; Inhwan Park; L Chinsoo Cho; Jianling Yuan; Kathryn E Dusenbery; Robert J Griffin; Seymour H Levitt
Journal:  Int J Radiat Oncol Biol Phys       Date:  2014-07-15       Impact factor: 7.038

Review 4.  The tumor radiobiology of SRS and SBRT: are more than the 5 Rs involved?

Authors:  J Martin Brown; David J Carlson; David J Brenner
Journal:  Int J Radiat Oncol Biol Phys       Date:  2014-02-01       Impact factor: 7.038

5.  A comparison of the effects of radiation on tumour growth delay and cell survival. The effect of oxygen.

Authors:  N J McNally
Journal:  Br J Radiol       Date:  1973-06       Impact factor: 3.039

Review 6.  Radiation-induced vascular damage in tumors: implications of vascular damage in ablative hypofractionated radiotherapy (SBRT and SRS).

Authors:  Heon Joo Park; Robert J Griffin; Susanta Hui; Seymour H Levitt; Chang W Song
Journal:  Radiat Res       Date:  2012-01-09       Impact factor: 2.841

7.  Tumor response to radiotherapy regulated by endothelial cell apoptosis.

Authors:  Monica Garcia-Barros; Francois Paris; Carlos Cordon-Cardo; David Lyden; Shahin Rafii; Adriana Haimovitz-Friedman; Zvi Fuks; Richard Kolesnick
Journal:  Science       Date:  2003-05-16       Impact factor: 47.728

8.  Tumor reoxygenation and postirradiation vascular changes.

Authors:  J J Clement; N Tanaka; C W Song
Journal:  Radiology       Date:  1978-06       Impact factor: 11.105

9.  Quantitative histological changes in a human melanoma xenograft following exposure to single dose irradiation and hyperthermia.

Authors:  K H Falkvoll
Journal:  Int J Radiat Oncol Biol Phys       Date:  1991-09       Impact factor: 7.038

10.  Dose escalation, not "new biology," can account for the efficacy of stereotactic body radiation therapy with non-small cell lung cancer.

Authors:  J Martin Brown; David J Brenner; David J Carlson
Journal:  Int J Radiat Oncol Biol Phys       Date:  2013-04-01       Impact factor: 7.038
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  1 in total

1.  Technical Note: Break-even dose level for hypofractionated treatment schedules.

Authors:  Till Tobias Böhlen; Jean-François Germond; Jean Bourhis; Marie-Catherine Vozenin; Claude Bailat; François Bochud; Raphaël Moeckli
Journal:  Med Phys       Date:  2021-10-22       Impact factor: 4.506
  1 in total

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