Insights into Friedman stage II and III OSA patients through drug-induced sleep endoscopy.

BACKGROUND: The Friedman staging is a classic system to predict outcomes of obstructive sleep apnea (OSA) surgery. Increasing stage indicates more severe upper airway (UA) obstruction and worse surgical successful rate. In previous studies, the UA obstruction between stages were usually assessed based on awake examination. Drug-induced sleep endoscopy (DISE) is a new method that can evaluate airway collapse characteristics during sleep. Therefore, we planned to compare Friedman staging and DISE findings and fulfill the knowledge gap on the correlation between awake and sedated UA examination.
METHODS: Retrospective case series study that assessed patients with OSA who underwent DISE. Subjects were classified to stage II and stage III groups based on Friedman staging system. UA collapse characteristics based on velum, oropharynx, tongue base, epiglottis (VOTE) classification, including single/multiple obstruction sites, single/combined upper and lower obstruction levels, collapse degree and patterns in different sites, and surgical results among the groups were analyzed.
RESULTS: A total of 175 cases were analyzed. No significant differences were found in baseline measurements between groups. Stage III patients (n=102) had a higher proportion (74.5%) with 3 or 4 obstruction sites than stage II (57.5%, n=73). Velum (V) + oropharynx (O) + tongue base (T) was the most common multi-sites combined obstruction pattern with 33% in stage II and 37% in stage III, isolated lower level obstruction was the least with 6% and 4%, respectively. No significant differences were found in obstruction sites and levels. 106 patients underwent surgeries and 33 had post-surgical sleep study, 73.7% and 63.6% response rate were found in stage II and III with no significant difference.
CONCLUSIONS: Upper and lower combined obstruction was the main pattern of collapse in both, Friedman stage II and III patients. Patients with OSA and Friedman stage III had more than 2 sites of obstruction than stage II patients. 2020 Journal of Thoracic Disease. All rights reserved.

Introduction

Obstructive sleep apnea (OSA) is associated with ailments such as socially unacceptable snoring, choking, frequent awakening, daytime sleepiness, fatigue, and comorbidities, such as hypertension (1), cardiovascular disease (2), cerebrovascular disease (3), diabetes (4), and overall increased mortality (5). Nocturnal intermittent hypoxia (NIH), sleep fragmentation, inflammation, increased sympathetic activity are considered as pathophysiological mechanisms contributing to general injuries (6-8). The prevalence is increasing from 3–7% to 13% in men population and 2–5% to 6% in women (9,10), and becoming a public health care issue.

Continuous positive airway pressure (CPAP) therapy is generally considered as the first-choice treatment for OSA, providing air pressure support to the upper airway (UA) lumen to relieve collapse. As a result, CPAP has been shown to improve sleepiness, increase quality of life (QOL) and decrease comorbidities (11-13). However, 46–83% do not tolerate CPAP or present an inadequate adaptation to it (14), and surgery is a reasonable and necessary alternative therapy. Uvulopalatopharyngoplasty (UPPP) was initially performed by Ikematsu (15) in 1952 for snoring, and introduced for OSA by Fujita (16), and still is the most commonly performed surgical procedure, however, its “success rate” or “response rate” has been described as limited and variable, ranging from 36% (17) to 78% (18) based on greater than 50% apnea hypopnea index (AHI) reduction and post-surgical AHI less than 20 (19). UA pressure measurements and endoscopy findings showed that patients with hypopharyngeal obstruction had a high percentage of relapses (20,21).

The Friedman staging system has been described as a simple and effective method to predict surgical outcomes according to the tongue-palate position relationship, tonsil size, craniofacial anatomy and body mass index (BMI) (22,23). It has been shown that hypopharyngeal obstruction, and therefore worse surgical outcomes for palatal surgery was associated with increase in staging, with 80.6% to stage I to 37.9% in stage II and 8.1% to stage III, respectively (24). A similar result was also described by Li et al. with a 96% UPPP successful rate in stages II vs. 65% in stage III (25). Although stage III subjects are thought to have less UA volume than stage II and higher proportion of retroglossal obstruction by pressure manometry (26), detailed differences about collapse characteristics across stages were not described in previous studies and need to be further explored.

Drug-induced sleep endoscopy (DISE) can be useful to evaluate obstructive airway characteristics during sleep (27) and its repeatability (28) and reliability (29,30) have been extensively described. Moreover, DISE has been more sensitive in finding hypopharyngeal collapse compared to awake endoscopy (31-33). To our knowledge, there are no studies assessing UA obstruction characteristics of different Friedman stages based on DISE. The objective of this study is to compare Friedman’s stages II and III and DISE findings in patients with OSA, therefore helping in fulfill an important knowledge gap on the correlation between awake and sedated UA examination.

Methods

Study design

Retrospective case series of OSA patients who underwent DISE at a tertiary referral center between June 2013 and May 2017. Inclusion criteria were subjects who: (I) had been diagnosed by in-laboratory polysomnography (PSG) or home based sleep test, with apnea-hypopnea index (AHI) ≥5 events/hour; (II) were intolerant to CPAP and who performed DISE to evaluate further therapy; (III) presented Friedman Staging System II or III. Patients who had previous history of UA procedures for sleep breathing disordered, including UPPP, palatal radiofrequency, genial tubercle advancement, tongue base reduction, maxillo-mandibular advancement or orthognathic surgeries, were excluded. Demographic and clinical features including age, gender, body mass index (BMI), Epworth Sleepiness Scale (ESS) score, tonsil size, Friedman tongue position (FTP); sleep study outcomes including AHI, oxygen desaturation index (ODI), lowest oxygen saturation (LSAT); DISE findings; and the surgeries performed after DISE and the polysomnographic variables after surgery performed between 3 to 6 months were extracted from Stanford’s Redcap and EPIC databases. Patients were divided into two groups: stage II and stage III, baseline characteristics, DISE findings and surgeries outcomes were compared, and associations were analyzed in all subjects.

The trial was conducted in accordance with the Declaration of Helsinki and the Harmonized Tripartite Guideline for Good Clinical Practice from the International Conference on Harmonization. This study was reviewed and approved by the Institutional Review Board and Hospital Research Ethics Committee of Stanford Hospital and Clinics (approval number 35054). All patients enrolled completed the informed consent form.

Sleep studies

Sleep studies were scored in accordance to the American Academy of Sleep Medicine 2012 edition. Apnea was identified when the amplitude of the airflow decreased ≥90% for ≥10 seconds. Hypopnea was identified when airflow amplitude decreased ≥30% for ≥10 seconds and was associated with oxygen desaturation ≥3% or an arousal. ODI represented the number of events of oxygen desaturation ≥3% per hour. LSAT represented the lowest oxygen saturation during sleep.

Friedman staging system

Only individuals in stages II and III were included. Stage II presented tonsil size 0, 1, or 2 with FTP I or II (stage IIa), or tonsil size 3 or 4 with FTP III or IV (stage IIb), and BMI <40. Stage III is tonsil size 0, 1, or 2 with FTP III or IV, and BMI<40 (23).

DISE protocol

The patients were placed in supine position in the operating room. Nasal decongestion oxymetazoline and topical lidocaine gel was applied to nasal valve area prior to endoscopy. Dexmedetomidine was the sedative agent, administered with an IV bolus at 1.5 mcg/kg over 10 minutes, followed by a maintenance infusion rate of 1.5 mcg/kg/h (34). An Olympus® flexible endoscope with a 3.2-mm diameter was inserted into the nose, UA obstructive subsites of velum (V), oropharynx (O), tongue (T), epiglottis (E) and levels of upper: velum and/or oropharynx (V/O); lower: tongue base and/or epiglottis (T/E); combined: V/O + T/E were observed. The assessment began after the first cycle of snoring and obstruction completed. The cycle is here defined as a complete and stable sequence of snoring-obstructed breathing, or desaturations. At least 2 cycles of obstructed breathing were observed for each subsite, as recommended by the European position paper on DISE (35). The duration of evaluation was 15 to 20 minutes. The grade and patterns of UA collapse were described by Velum oropharynx tongue base epiglottis (VOTE) classification (36). All evaluations were performed and classified exclusively by a senior and experienced surgeon (R.C).

Statistical analysis

Continuous variables were summarized with mean ± standard deviation, meanwhile some variables (AHI, ODI, LSAT, ESS) lack of normality distribution were aware and median (range) were demonstrated. Categorical variables were summarized with frequencies and percentages. Continuous variables were compared using Student t-test when normally distributed or Wilcoxon rank sum test to another way. Categorical variables were compared using Fisher’s exact test or Wilcoxon rank-sum test when categories were ordered. Logistical regression model was used to analyze the association between stage II/III and single/multiple obstructive sites; isolated upper or lower level /combined levels obstruction; non (0: <50%), partial (1: 50–75%) and complete (2: <75%) collapse; 0/1+2 collapse in subsites with differential collapse patterns. All models were presented no adjustment and adjustment for age, gender, BMI. All the analyses were performed by SAS 9.4 (SAS Inc, Cary, NC, USA). P<0.05 was considered statistically significant.

Results

The study assessed 193 records. Eighteen patients were excluded as they underwent prior surgical procedures for OSA. Baseline characteristics including age, BMI, ESS, AHI, ODI, LSAT were compared across groups and no significant differences were found as shown in .

Table 1

Baseline characteristics between groups

Characteristics	Stage II (n=73)	Stage III (n=102)	P value
Age, years (mean ± SD)	47.8±15.6	48.4±15.0	0.792*
Male, n (%)	55 (75.3%)	87 (85.3%)	0.118**
BMI, kg/m2 (mean ± SD)	27.2±4.5	28.4±4.4	0.081*
ESS, scores (mean ± SD)	9.3±5.5 (n=71)	10.0±4.8 (n=95)
Median [range]	9 [5–14]	10 [7–14]	0.314***
AHI, events/hour (mean ± SD)	34.9±22	39.0±19.8
Median [range]	30.6 [18–46]	36.1 [24.2–51.2]	0.092***
ODI, events/hour (mean ± SD)	22.9±21.7 (n=45)	26.2±22.3 (n=68)
Median [range]	14.6 [5.9–32.7]	20.7 [9.8–35.6]	0.288***
LSAT, % (mean ± SD)	84.4±7.0	82.2±9.3
Median [range]	86 [81–89]	84 [77.5–90]	0.141***

*, student t-test; **, Pearson Chi-square test; ***, Wilcoxon rank-sum test. Values are statistically significant as P<0.05. BMI, body mass index; ESS, Epworth Sleepiness Scale; AHI, apnea hypopnea index; ODI, oxygen desaturation index; LSAT, lowest oxygen saturation.

Collapse pattern and obstruction degree in VOTE showed no significant difference between the two groups; there was no significant association between stage II or III, obstruction sites, single or multiple sites obstruction, isolated or combined levels obstruction, in either unadjusted or adjusted logistic regression models, for partial or complete collapse ().

Table 2

Association between stage (II or III) and obstruction pattern, degree in VOTE sites

Sites	Pattern	Degree	OR unadjusted	P value	OR adjusted	P value
Velum	AP	1+2	0.73 (0.4–1.33)	0.300	0.75 (0.4–1.42)	0.383
		2	0.93 (0.51–1.69)	0.807	0.92 (0.48–1.74)	0.787
	L	1+2	0.95 (0.21–4.39)	0.950	0.98 (0.19–5.02)	0.981
		2	1.08 (0.18–6.61)	0.937	1.17 (0.15–9.14)	0.878
	C	1+2	1.46 (0.78–2.75)	0.240	1.35 (0.7–2.59)	0.367
		2	1.89 (0.97–3.68)	0.060	1.66 (0.83–3.31)	0.153
Oropharynx	L	1+2	1.89 (0.95–3.75)	0.069	1.62 (0.79–3.31)	0.188
		2	1.43 (0.76–2.68)	0.265	1.22 (0.61–2.41)	0.574
Tongue base	AP	1+2	1.56 (0.78–3.13)	0.213	1.6 (0.79–3.26)	0.192
		2	0.86 (0.46–1.63)	0.653	0.86 (0.45–1.66)	0.660
Epiglottis	AP + L	1+2	1.66 (0.87–3.17)	0.120	1.73 (0.89–3.34)	0.105
		2	1.1 (0.55–2.19)	0.787	1.12 (0.55–2.27)	0.761

VOTE, velum, oropharynx, tongue base, epiglottis; AP, anterior-posterior; L, lateral; C, concentric; 1, partial collapse with 50–75% obstruction; 2, complete collapse with 75–100% obstruction. OR adjusted for age, gender, body mass index. Statistically significant as P<0.05.

Table 3

Collapse pattern and obstruction degree between groups

Site/pattern/degree	OSA, n (%)		P value
	Stage II (n=73)	Stage III (n=102)
Velum			0.259*
AP
0	4 (5.5)	5 (4.9)
1	8 (11.0)	5 (4.9)
2	35 (47.9)	47 (46.1)
L
0	0 (0.0)	0 (0.0)
1	1 (1.4)	1 (1.0)
2	2 (2.7)	3 (2.9)
C
0	0 (0.0)	0 (0.0)
1	5 (6.8)	2 (2.0)
2	18 (24.7)	39 (38.2)
Oropharynx			0.099**
L
0	24 (32.9)	21 (20.6)
1	25 (34.2)	39 (38.2)
2	24 (32.9)	42 (41.2)
Tongue base			0.741**
AP
0	21 (28.8)	21 (20.6)
1	26 (35.6)	48 (47.1)
2	26 (35.6)	33 (32.4)
Epiglottis			0.146*
AP
0	52 (71.2)	61 (59.8)
1	3 (4.1)	13 (12.7)
2	16 (21.9)	26 (25.5)
L
0	0 (0.0)	0 (0.0)
1	0 (0.0)	1 (1.0)
2	2 (2.7)	1 (1.0)

*, student t-test; **, Fisher exact test.

There was a significant higher proportion (74.5%) of more than 2 obstructive sites in stage III patients than in stage II patients (57.5%), P=0.022 (). However, there was no significant difference in the distribution of obstruction levels between the stages as shown in .

Figure 1

Comparison of multiple obstruction with 1 or 2 and 3 or 4 sites between groups. 74.5% patients in stage III had multiple obstruction with 3 or 4 sites, that was higher than 57.5% in stage II, P=0.022. *, statistical analysis by Fisher exact test. Statistically significant as P<0.05.

Figure 2

Comparison of upper level, lower level and combined obstruction between groups. Seventy-one percent patients in stage II presented combined obstruction with partial and complete collapse, and 81% in stage III. V + O + T was the most multi-sites obstructive pattern in both groups with 33% and 37%, respectively. There was no significant difference on obstructive level between groups, statistical analysis by Fisher exact test, P=0.301. Upper level: velum and/or oropharynx (V/O); lower level: tongue base and/or epiglottis (T/E); combined: V/O + T/E. Statistically significant as P<0.05.

One-hundred and six patients underwent surgery after DISE and 33 patients had a post-surgical sleep study between 3 to 6 months that were available at the time of this study. No significant difference was found in baseline characteristics, pre- and post-surgical sleep study outcomes, surgical response rate between groups (). The same can be seen in relation the surgical procedures performed across groups ().

Table 4

Comparison of baseline and post- surgical outcomes between groups

Characteristics	Stage II (n=11)	Stage III (n=22)	P value
Age, years (mean ± SD)	39.6±12.7	45.3±11.1	0.228**
Male, n (%)	7 (63.6)	18 (81.8)	0.391**
BMI, kg/m2 (mean ± SD)	29.2±5.5	29.9±4.3	0.701*
ESS, scores (mean ± SD)
Pre	11.4±4.6 (n=10)	10.9±5.2 (n=21)	0.932***
Post	6.5±3.4 (n=4)	4.1±3 (n=8)	0.225***
AHI, events/hour (mean ± SD)
Pre	36.6±32.1	44.8±25.1	0.175***
Post	10.4±5.3	15±11.4	0.359***
Ä%	52.5±38.1	56.9±45.2	0.567***
ODI, events/hour
Pre	23±19.3 (n=10)	32.2±33 (n=13)	0.535***
Post	5.7±4.5 (n=11)	11.2±10.2 (n=18)	0.213***
Ä%	42.2±77.6 (n=9)	38.2±46 (n=11)	0.47***
LSAT, % (mean ± SD)
Pre	85.3±6.6	81.7±10.5	0.349***
Post	88.4±4.7	88.1±4	0.893***
Ä	3.1±7.5	6.5±10	0.811***
Surgical response rate, %	72.7 (n=8)	63.6 (n=14)	0.709**

*, student t-test; **, Fisher exact test; ***, Wilcoxon rank-sum test. Values are statistically significant as P<0.05. BMI, body mass index; ESS, Epworth Sleepiness Scale; AHI, apnea hypopnea index; ODI, oxygen desaturation index; LSAT, lowest oxygen saturation; Pre, pre-surgery; Post, post-surgery; Ä, difference between pre and post-surgery/pre-surgery. Surgical response rate, ÄAHI% >50% and post-surgical AHI <20.

Table 5

Surgical procedures between groups

Surgical procedures	Stage II (n=11)	Stage III (n=22)	P value
Lateral pharyngoplasty ± tonsillectomy	1 (9.1%)	3 (13.6%)	–
Lateral pharyngoplasty + coblation/radiofrequency/TORS tongue base reduction surgery	6 (54.5%)	12 (54.5%)	–
Lateral pharyngoplasty + genioplasty/GGA	1 (9.1%)	1 (4.5%)	–
Lateral pharyngoplasty + septoplasty/turbinate radiofrequency	1 (9.1%)	3 (13.6%)	–
MMA	2 (18.2%)	2 (9.2%)	–
Maxillary expansion	–	1 (4.5%)	0.979

TORS, transoral robot surgery; GGA, genioglossal advancement; MMA, maxillomandibular advancement. Statistical analysis by Fisher exact test. Statistically significant as P<0.05.

Discussion

In this study, DISE was used to explore the UA obstructive features in Friedman's stages II and III. To our knowledge, no articles were published to analyze the correlation between DISE findings and Friedman staging. The main finding in this study was that stage III patients had a significantly higher proportion of more than 2 obstructive sites when compared to stage II patients. Most patients presented upper and lower level combined obstruction in both stage II and III, V + O + T was the most verified association. Surgical procedures based on DISE assessment could obtain similar success rate in both stage III and stage II patients.

In general, most Friedman II and III stage subjects presented multisites UA obstruction (91.8% in stage II and 97.1% in stage III), combined obstructions of palatopharynx and hypopharynx (71% and 81%, respectively), but less isolated hypopharyngeal obstruction (4% and 6%, respectively). As comparison, the percentage of multiple sites obstruction and isolated hypopharyngeal obstruction was 68.2% (37) and 11% (38) in broad sleep-disordered breathing population, respectively. DISE provided new evidence about collapse characteristics in those subjects, who were more susceptible to multi-site combined collapse and obstruction. Meanwhile, velum was still the most common collapse site with 94.5% and 96.1% in stages II and III, respectively.

The main difference between stages was that stage III subjects were more susceptible to more than two obstructive sites, with increased severity of hypopharyngeal obstruction, contributing to lower success rates than stage II. Meanwhile, there was a higher proportion of lateral wall narrowing in stage II (67.1%) and III (79.4%) compared to the general OSA population (35%) (39). This likely contributes to a lower surgical success rate to soft tissue procedures in this sub-population by non skeletal procedures (40,41), however surgical responses and results may be better through maxillomandibular advancement (MMA) (42). In our experience, simultaneous hypopharyngeal procedures are considered based on DISE findings to improve surgical results. MMA was considered thoughtfully if hypopharyngeal lateral wall collapse is observed.

Some studies concluded that it was unnecessary to perform DISE since there would be no significant outcome difference between all-sites and partial-sites surgical intervention (43,44), but DISE revealed more multiple sites obstruction and pharyngeal lateral wall collapse in high AHI patients (37,45,46). Spector et al. found 70% success rate in stage II and 66% in stage III through multilevel surgeries by DISE directions (47).

Other studies did not find the relationship between Friedman stage and incidence of retroglossal collapse (48,49). Similarly, the association between high FTP and tongue base obstruction was not found either (50,51). Our results showed that either retroglossal or retropalatal, oropharyngeal and epiglottal collapse had no significant association with stages II or III. Therefore, while Friedman staging may be a primary method for judging the severity of collapsibility, DISE provides additional evaluation with more information identifying the obstructive characteristics of the patient with OSA.

One limitation of this study was that most subjects of stage II were classified as IIa (86.3%). In general, patients with tonsils 3 or 4 were seldom performed DISE prior to surgery, according to the protocol used by our department. It is known that cases with higher amygdala grade in general have a positive correlation with higher AHI and higher success rate (52-54). In addition, the subjects who were from sleep clinic and CPAP intolerant and sought for possible surgical therapy may have increased our selection bias. Besides that, DISE findings also altered with type (55), depth (56) and duration of sedation (57), the protocol that we used only applied dexmedetomidine, thus not allowing comparison with other studies using different drugs.

Conclusions

Upper and lower combined obstruction was the main collapse characteristic in both groups. Friedman stage III subjects had more than 2 sites of obstruction when compared to stage II patients. No differences were identified for the degree and form of obstruction between stages II and III.

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