Research Trends of Acupuncture Therapy on Knee Osteoarthritis from 2010 to 2019: A Bibliometric Analysis.

BACKGROUND: Acupuncture has been widely applied to relieve knee osteoarthritis (KOA) in many countries. However, the bibliometric analysis of the global use of acupuncture on KOA is largely unknown. Therefore, this study aimed to explore the current status and trends of the global use of acupuncture on KOA in recent 10 years by using CiteSpace (5.6.R3).
METHODS: Publications regarding acupuncture therapy for treating KOA between 2010 and 2019 were extracted from the Web of Science database. CiteSpace was used to analyze the number of publications, countries, institutions, journals, authors, cited references and keywords by using standard bibliometric indicators.
RESULTS: A total of 343 publications were retrieved from 2010 to 2019. The total number of publications continually increased over the past four years, and the most active journals, countries, institutions and authors in the field of acupuncture therapy on patients with KOA were identified. The Evid Based Complement Alternat Med (28) was the most prolific journal, and the Ann Intern Med (202) was the most cited journal. The most productive country and institution in this field was China (115) and University of York (18), respectively. Hugh Macpherson (18) was the most prolific author and Witt C ranked the first in the cited authors. In the ranking of frequency in cited reference, the first article was published by Scharf HP (54). The keyword of 'randomized controlled trial' ranked first for research developments with the highest citation burst (3.9486). Besides, there were three main frontiers in keywords for KOA research, including 'research method, 'age' and 'measure of intervention'.
CONCLUSION: The findings from this bibliometric study provide current status and trends in clinical research of acupuncture therapy on patients with KOA over the past ten years, which may help researchers identify hot topics and explore new directions for future research in this field.

Introduction

Knee osteoarthritis (KOA) is one of the most common chronic degenerative diseases, which was characterized by joint pain, numbness, ankylosis and dysfunction, sometimes with progressive intraarticular cartilage and subchondral bone injury, synovitis, osteophyte formation, and joint cavity reduction.1,2 The genetics, age, female gender, obesity, overuse, misalignment and previous knee trauma are generally considered as high-risk factors for KOA.3–6 About 22% of the general population suffers from KOA-associated pain, and the prevalence is higher in middle-age and elderly people.7 This disease constantly affected the quality of patients’ life and caused some emotional disturbances, such as anxiety, depression and insomnia.8,9

Recently, there is no consensus on the best treatment to improve the symptoms of KOA. Standard pharmacological treatments always choose analgesics and nonsteroidal anti-inflammatory drugs (NSAIDs) to alleviate symptoms in patients with KOA. However, it usually brings obvious adverse effects, such as gastrointestinal reactions, hepatorenal toxicity, and adverse events with the risk of cardiovascular.10–12 In recent years, exercise therapy was strongly recommended intervention for KOA based on international guideline, and most scholars advocated exercise therapy as the preferred rehabilitation method for KOA.13–15 Meanwhile, numbers of empirical studies have also demonstrated that exercise therapy could improve the quality of patients’ life, effectively relieve the pain and promote functional recovery.16–18 However, poor long-term adherence is a serious problem that affects the therapeutic effect of exercise treatment.19 Apart from the aforementioned therapies, as a complementary therapy, acupuncture has become a favorable option for KOA treatment. Moreover, the efficacy of acupuncture on KOA has been confirmed by numerous randomized controlled trials,20–22 but the treatment method of KOA is still a research topic.

Bibliometrics refers to the cross-science of quantitative analysis of all knowledge carriers by using mathematical and statistical methods, and it is a statistical analysis and quantitative tool to study publications.23 Over the past ten years, studies have confirmed the effectiveness of acupuncture for KOA.24–26 However, to the best of our knowledge, a specific bibliometric analysis of the global use of acupuncture for KOA has not yet been performed. Therefore, it is essential to understand the current status of acupuncture research on KOA as a whole. This study aims to evaluate the research trends of acupuncture treatment on KOA and conduct a macroscopic overview of a significant amount of academic literature in the past ten years through bibliometric analysis.

CiteSpace is a visualization tool invented by Professor Chaomei Chen, which is characterized by co-occurrence network maps of countries, institutions, authors, keywords and co-citation network of cited journals, cited authors, cited references.27–29 In this study, CiteSpace was used to make a bibliometric analysis to explore the current status and research trends on the global use of acupuncture therapy on KOA within the past 10 years (from 2010 to 2019), and all eligible literature was extracted from the Web of Science database.

Methods

All data in this study were obtained from the Web of Science on 1 March 2020. The data search strategy included the topic “knee osteoarthritis” and “acupuncture therapy”, with the publications period of the literature ranging from 2010 to 2019. In addition, the countries, categories and language of publications were not been restricted. The specific search strategies and results are shown in Table 1.

Table 1

The Topic Search Query

Set	Results	Search Query
#1	28,361	(TS=((Osteoarthritis, Knee) OR (Knee Osteoarthritis) OR (Knees Osteoarthritis) OR (Osteoarthritis, Knees) OR (Osteoarthritis of knee) OR (Osteoarthritis Of Knees) OR (Knee, Osteoarthritis Of) OR (Knees, Osteoarthritis Of))Indexes=Web of Science, Timespan=20102019
#2	10,322	(TS=((Acupuncture Therapy)OR (Acupuncture Treatments)OR (Acupuncture Treatment)OR (Acupuncture)OR (body acupuncture)OR (Needle Acupuncture)OR (Manual Acupuncture)OR (Acupuncture Points)OR (Electroacupuncture)OR (Warm Acupuncture)OR electro-acupuncture)Indexes=Web of Science, Timespan=20102019
#3	343	#1 AND #2

Bibliometric analysis was performed to analyze the trends and patterns in the identified publications by using CiteSpace (5.6.R3) software, which was used to clarify the annual output counts, the prolific journals, authors, institutions and countries.29 Meanwhile, we also researched the cooperation relationships, such as co-occurrence analysis of keywords, authors, references and institutions. The current research basis, cutting-edge knowledge and research trends of acupuncture treatment on KOA were obtained by bibliometric visualized analysis.

The parameters of CiteSpace were set as below: time slicing was from 2010 to 2019, years per slice (1), all options in the term source were selected, one node type was selected at a time, selection criteria (top 50 objects), and pruning (pathfinder). Visualization knowledge figures were mainly composed of nodes and links. Each node in the map represented an element, such as author, keyword, institution, etc. The size of node, which commonly suggested the frequency of appearance or citation, and different colors of nodes indicated the different years and the circles of different colors represented the year of 2010 to 2019 from the inside to the outside of the nodes. Furthermore, lines between the nodes signified cooperation or co-occurrence or co-citation relationships. The purple circle represented centrality, nodes with high centrality were usually considered as pivotal points or key points in a specific field.30,31

Results and Discussion

Annual Publications

By searching for the topic words in Web of Science, a total of 343 articles were included. The number of specific articles published each year is shown in Figure 1. In our study, we found that the number of publications on acupuncture therapy of KOA has fluctuated over the past 10 years. From 2010 to 2011, the number of publications decreased from 39 references to 29 references. Although the number of publications increased again in 2012, it did not restore the level of 2010. From 2012 to 2015, the number of published articles decreased significantly, and the lowest publications were in 2015, with only 19 publications. However, the number of publications increased rapidly in 2016. Furthermore, the number of publications increased continually from 2015 to 2019. The trend of publications’ number indicated that acupuncture, as a complementary treatment, has received more attention, and more studies have been carried out to observe the efficacy of acupuncture on KOA in recent years.

Figure 1

The annual number of publications on acupuncture treatment for KOA between 2010 to 2019.

Analysis of Journals and Cited Journals

The top 10 journals of acupuncture treatment on KOA are shown in Table 2. The average impact factor (IF) of the top 10 journals was 2.386, and Evidence-Based Complementary And Alternative Medicine was the most productive journal, with a total of 28 articles, which was followed by Acupuncture In Medicine, with a total of 24 articles. Furthermore, we found that the Osteoarthritis And Cartilage with the highest IF is a professional journal in this field, with an IF of 4.879. The co-citation combined with centrality, a cited journal map was generated by CiteSpace, including the total of 5773 references (shown in Figure 2 and Table 3). The nodes in the map represented journals, and links between the nodes meant co-citation relationships. In addition, the purple ring indicated the centrality of literature, it was crucial that nodes with high centrality were usually considered as pivotal points in the literature. Thus, the first in the frequency and centrality were Ann Intern Med, and Trails, respectively. In the journal cited in 202 records of Ann Intern Med, one article got the larger citation, which performed a meta-analysis of acupuncture therapy on 4 chronic pain diseases, and manifested the efficacy of acupuncture was better than both of no-acupuncture control and sham acupuncture in the treatment of KOA. Meanwhile, the results from the meta-analyses provided that the most robust evidence to date that acupuncture is a reasonable referral option for patients with KOA.32

Table 2

Top 10 Scholarly Journals Related to Acupuncture Therapy on KOA

Rank	Publications	Journal	IF (2019)	Rank	Publications	Journal	IF (2019)
1	28	Evidence-Based Complementary And Alternative Medicine	1.984	6	9	Journal of Alternative And Complementary Medicine	1.868
2	24	Acupuncture In Medicine	2.637	7	8	BMJ Open	2.376
3	17	Trials	1.975	8	8	Journal of Traditional Chinese Medicine	0.907
4	14	Osteoarthritis And Cartilage	4.879	9	8	Plos One	2.776
5	9	BMC Complementary and Alternative Medicine	2.479	10	7	Complementary Therapies In Medicine	1.979

Figure 2

Cited journal maps related to acupuncture treatment for KOA research from 2010 to 2019. The nodes in the map represent journals, and lines between the nodes represent co-citation relationships. The various colors in the nodes represent the different years. The larger the node area, the greater the number of co-citations. The purple ring represents centrality, and nodes with high centrality are considered as pivotal points in the literature.

Table 3

Top 5 Cited Journals and Centrality Related to Acupuncture Therapy on KOA

Rank	Cited Journal	Frequency	Rank	Cited Journal	Centrality
1	Ann Intern Med	202	1	Trials	0.47
2	Pain	201	2	Anesth. Analg	0.43
3	Osteoaryhr Cartilage	168	3	Clin Rheumatol	0.37
4	Acupunct Med	167	4	JCR-J Clin Rheumatol	0.37
5	Lancet	160	5	Clin Rehabil	0.34

Distribution of Countries and Institutions

Distribution of countries map was generated, 16 nodes and 53 links composed of the merged network (Figure 3). The 343 references were published by researchers in 16 countries, and the top 5 countries for centrality (purple ring) were England (1.28), Canada (0.97), Sweden (0.63), USA (0.46), and Denmark (0.46). Besides, the top 10 countries of publications are displayed in Table 4. A total of 115 references were published in China, which may be related to the fact that acupuncture originated from China. USA was ranked in the second position (109), thereby, indicating that acupuncture treatment for KOA has been widely used in the USA. Additionally, China and South Korea were the most productive countries in Asia, while the USA and England were the most prolific countries in the West (Table 4). Further analysis revealed that more high-quality randomized controlled trails of acupuncture therapy on KOA were being conducted.33–36

Figure 3

Map of countries researching acupuncture for KOA from 2010 to 2019. The nodes in the map represent countries or territories. The lines between the nodes represent cooperation relationships. The various colors in the nodes represent the different years, and the larger the area of the node, the larger the number of publications. The purple ring represents centrality, and nodes with high centrality are considered as pivotal points in the literature.

Table 4

Top 10 Publications and Centrality of Countries Related to Acupuncture Therapy on KOA

Rank	Publications	Countries	Rank	Centrality	Countries
1	115	Peoples R China	1	1.28	England
2	109	USA	2	0.97	Canada
3	61	England	3	0.63	Sweden
4	27	Germany	4	0.46	USA
5	24	South Korea	5	0.46	Denmark
6	17	Australia	6	0.25	Peoples R China
7	13	Canada	7	0.25	Netherlands
8	8	Taiwan	8	0.25	Brazil
9	7	Netherlands	9	0.25	Switzerland
10	6	Brazil	10	0	Germany

Distribution of institutions map consists of 62 nodes and 106 links (Figure 4). A total of 62 institutions were dedicated to the research of acupuncture treatment on KOA, among which the top 5 institutions of publications were University of York (18), Beijing University of Chinese Medicine (13), Chengdu University of Traditional Chinese Medicine (12), University of Maryland (9), and University of Southampton (9), respectively (Table 5). Interestingly, University of York was not only the most prolific institution, but also the highest centrality institution, suggesting that University of York is the most important institution for researching acupuncture treatment of KOA. Meanwhile, the top 3 centrality institutions included University of York, University of Maryland and Chinese Academy of Medical Sciences. Therefore, based on the publications and centrality, we found that the institutions from England, USA, and China paid more concerns on the research of acupuncture treatment in KOA currently, and the University of York, Sichuan University and University of Southampton were the strongest cooperation institutions.

Figure 4

Map of institutions researching acupuncture for KOA from 2010 to 2019. The nodes in the map represent institutions, and lines between the nodes represent collaborative relationships. The various colors in the nodes represent the different years, and the larger the node area, the larger the number of publications. The purple ring represents centrality, and nodes with high centrality are considered as pivotal points in the literature.

Table 5

Top 10 Publications and Centrality of Institutions Related to Acupuncture Therapy on KOA

Rank	Publications	Institutions	Rank	Centrality	Institutions
1	18	Univ York	1	0.29	Univ York
2	13	Beijing Univ Chinese Med	2	0.27	Univ Maryland
3	12	Chengdu Univ Tradit Chinese Med	3	0.24	Univ Hong Kong
4	9	Univ Maryland	4	0.21	Capital Med Univ
5	9	Univ Southampton	5	0.09	Sichuan Univ
6	8	Capital Med Univ	6	0.09	China Acad Chinese Med Sci
7	8	Kyung Hee Univ	7	0.08	Beijing Hosp Tradit Chinese & Western Med
8	7	China Acad Chinese Med Sci	8	0.08	Hebei Univ Chinese Med
9	7	Sichuan Univ	9	0.06	Charite
10	7	Univ Exeter	10	0.03	Keele Univ

Analysis of Authors and Cited Authors

The authors of the 343 publications were analyzed and resulted in 104 nodes and 303 links (Figure 5), indicating that the 343 articles were published by 104 authors. The map of authors was designed to reveal the most prolific author or co-author, as well as demonstrate the closeness of collaboration among the authors, which could provide information on influential research groups and potential collaborators, and help researchers establish cooperative relationships. The top 5 authors were Hugh Macpherson, Claudia M Witt, Lixing LAO, Andrew J Vickers, and Adrian White (Table 6). Among them, the most prolific author was Hugh Macpherson, from the University of York in the United Kingdom, with 13 articles. The cost-effectiveness study of assisted non-pharmacological interventions for KOA performed by Hugh Macpherson found that high-quality KOA clinical trials were urgently needed and the effective cost of acupuncture was the lowest among non-pharmacological interventions.37 In addition, some of his system reviews and meta-analysis articles also indicated that referral acupuncture treatment was a reasonable choice for patients with KOA.38,39 However, there was still a lack of high-quality randomized controlled trials to provide sufficient evidence to demonstrate the therapeutic effects of acupuncture therapy on KOA. Moreover, the links showed that the cooperation between authors in this field was not close, suggesting that authors can collaborate to produce more high-quality articles in the future.

Figure 5

Map of author related to acupuncture for KOA from 2010 to 2019. The nodes in the map represent authors, and lines between the nodes represent the collaborative relationships. The various colors in the nodes represent the different years, and the larger the node area, the greater the number of publications.

Table 6

Top 10 Prolific Authors Related to Acupuncture Therapy on KOA

Rank	Publication	Author	Rank	Publication	Author
1	13	Hugh Macpherson	6	6	Jian KONG
2	8	Claudia M Witt	7	5	Cunzhi LIU
3	8	Lixing LAO	8	5	George Lewith
4	7	Andrew J Vickers	9	4	Yong TANG
5	6	Adrian White	10	4	Lize XIONG

The map of cited authors was composed of 408 nodes and 1348 links (Figure 6). Witt C had the highest citation counts (102), followed by Berman BM (99), Manheimer E (97), Scharf HP (84) and Bellamy N (72) (Table 7). The top 5 centrality of cited authors included CHEN LX (0.31), Barnes PM (0.26), White A (0.25), Bennell KL (0.25) and Diener HC (0.19) (Table 7). A comprehensive analysis found that Witt C, Berman BM, CHEN LX and Barnes PM were the professors in the field, and had an important influence on the development of acupuncture treatment of KOA. Witt C ranked the first in the cited author frequency and he is a professor at Charite University Medical Center. One of her articles pointed out that the results of randomized controlled trials were summarized in systematic reviews and meta-analysis, these reviews and meta-analysis were often used to provide decision-makers with decision-making information. However, it was necessary to carry out relevant researches to obtain more evidences about the effectiveness and cost-effectiveness of acupuncture therapy on KOA. In addition, a further understanding of the mechanism of acupuncture therapy on KOA was also urgently warranted.40 Berman BM, who is from the University of Maryland School of Medicine, mainly devoted to investigate the mechanism of pain, one of his opinion was that acupuncture treatment provided more significant improvement in function and pain relief as an adjunctive therapy on KOA when compared with credible sham acupuncture and education control groups. Hence, acupuncture may have an important role to relieve symptoms related to KOA.41

Figure 6

Map of cited author related to acupuncture for KOA from 2010 to 2019. The nodes in the map represent co-cited authors, and lines between the nodes represent co-citation relationships. The various colors in the nodes represent the different years. The larger the node area, the greater the number of co-citations. The purple ring represents centrality, and nodes with high centrality are considered to be pivotal points in the literature.

Table 7

Top 5 Frequency and Centrality of Cited Authors Related to Acupuncture Therapy on KOA

Rank	Frequency	Author	Rank	Centrality	Author
1	102	Witt C	1	0.31	CHEN LX
2	99	Berman BM	2	0.26	Barnes PM
3	97	Manheimer E	3	0.25	White A
4	84	Scharf HP	4	0.25	Bennell KL
5	72	Bellamy N	5	0.19	Diener HC

Analysis of Cited References

The top 5 frequency and centrality of cited references were shown in Tables 8 and 9. By analyzing the literature with high co-citation frequency and centrality, the knowledge foundation of the subject could be obtained. The top 3 articles were all the randomized controlled trials of acupuncture treatment on KOA and were published in Ann Intern Med, Lancet and JAMA, respectively,42–44 indicating that the importance of these articles in this field, which also had a greater influence in this field. Additionally, the meta-analysis published by Vickers AJ, which was ranked the fourth list, suggested that acupuncture was an effective method for treating chronic osteoarthritis pain, the therapeutic effect of acupuncture persisted with the progress of time and could not be explained by the placebo effects only.32 The centrality of cite references ranked the first conducted by Mavrommatis CI, who carried out a 3-armed, single-blind, randomized, sham-controlled trail to compare the efficacy of acupuncture and medicine in the treatment of KOA, and results revealed that acupuncture combined with medicine had the best curative effect.45 A total of 9372 records were generated by 343 publications to analysis cited references, and the map with 538 nodes and 1880 links were obtained (Figure 7). Over the past decade, the comprehensive analysis mainly focused on randomized controlled trials of acupuncture treatment for KOA, individual patient data (IPD) meta-analysis, analgesic mechanisms based on nerves and receptors, researching placebo effects, and developing the corresponding guidelines for the treatment of KOA.

Table 8

Top 5 Frequency of Cited References Related to Acupuncture Therapy on KOA

Rank	Frequency	References	Author and Publication Year
1	54	Acupuncture and knee osteoarthritis: a three-armed randomized trial42	Scharf HP (2006)
2	46	Acupuncture in patients with osteoarthritis of the knee: a randomised trial43	Witt C (2005)
3	45	Acupuncture for chronic knee pain: a randomized clinical trial44	Hinman RS (2014)
4	44	Acupuncture for chronic pain: individual patient data meta-analysis45	Vickers AJ (2012)
5	38	American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee46	Hochberg MC (2012)

Table 9

Top 5 Centrality of Cited References Related to Acupuncture Therapy on KOA

Rank	Centrality	References	Author and Publication Year
1	0.21	Acupuncture as an adjunctive therapy to pharmacological treatment in patients with chronic pain due to osteoarthritis of the knee: a 3-armed, randomized, placebo-controlled trial45	Mavrommatis CI, 2012
2	0.18	American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee	Hochberg MC (2012)
3	0.15	A randomized trial comparing acupuncture, simulated acupuncture, and usual care for chronic low back pain47	Cherkin DC, 2009
4	0.14	Convincing evidence from controlled and uncontrolled studies on the lipid-lowering effect of a statin48	Higgins J, 2012
5	0.13	The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients49	Chen XY, 2015

Figure 7

Map of cited references related to acupuncture for KOA from 2010 to 2019. The nodes in the map represent cited references, and lines between the nodes represent co-citation relationships. The various colors in the nodes represent the different years, and the larger the node area, the greater the number of co-citations. The purple ring represents centrality, and nodes with high centrality are considered as pivotal points in the literature.

Analysis of Keywords

It was considered that the indicators for evaluating the most cutting-edge themes or emerging trends were the increased number of keyword burst in citation or the increased frequency of keywords within a certain period of time.46 The map of keywords co-occurrence was generated and consisted of 160 nodes and 616 links (Figure 8). According to the frequency and centrality, we found the popular keywords were “acupuncture”, “osteoarthriti”, “pain”, “knee”, “knee osteoarthriti”, “randomized controlled trial”, “intervention” and “meta-analysis” (Table 10). The top 15 keywords with the strongest citation burst from 2010 to 2019 are shown in Figure 9. The most recent burst keywords were “randomized controlled trial”, “double blind”, “older adult”, “OARSI recommendation”, “placebo”, “expectation”, “electroacupuncture (EA)”, “safety” and “alternative medicine”. The 3 frontiers in burst strength were ‘research method, “age” and “measure of intervention”. Randomized controlled trial was the most important research method to evaluate the efficacy of acupuncture therapy on KOA, which could also provide high-quality evidence-based testimony. Meanwhile, it was necessary to declare the implementation of blind method.47 However, it was difficult to achieve double blinding for operators and patients in acupuncture studies. Hence, some single-blind trials had been conducted.45,48 Data have shown that more than 19.4% of people over the age of 60 years suffered from KOA, which seriously affected their quality of life. Besides, more than 20 million Americans, as well as 35 to 40 million Europeans experienced KOA, especially in elderly individuals.49,50 Therefore, this phenomenon highlights the importance of studying KOA in the older adults. The keyword “electroacupuncture”, emerging from 2018, has shown the strength of citation burst of 2.8472, thereby indicating that EA had gained more popularity than manual acupuncture in recent years. A study was conducted to investigate the optimal intensity of EA for patients with KOA, and the results showed that strong EA (>2mA) was better than weak or sham EA in alleviating pain intensity and inhibiting chronic pain.35 However, studies found that the efficacy of EA on pain relief and function improvement in patients with KOA was also not confirmed when compared to manual acupuncture.25 Therefore, more studies should be carried out for further investigation.

Figure 8

Map of keywords occurrence related to acupuncture for KOA from 2010 to 2019. The nodes in the map represent keywords. The lines between the nodes represent co-occurrence relationships. The various colors in the nodes represent the different years, and the larger the node area, the higher the frequency. The purple ring represents centrality, and nodes with high centrality are considered as pivotal points in the literature.

Table 10

Top 10 Frequency and Centrality of Keywords Related to Acupuncture Therapy on KOA

Rank	Keyword	Frequency	Rank	Keyword	Centrality
1	Acupuncture	170	1	Meta-analysis	0.30
2	Osteoarthriti	131	2	Randomized controlled trial	0.30
3	Pain	105	3	Low back pain	0.24
4	Knee	87	4	Intervention	0.22
5	Knee osteoarthriti	84	5	Trigger point	0.20
6	Randomized controlled trial	82	6	Systematic review	0.18
7	Hip	66	7	Neck pain	0.17
8	Low back pain	61	8	Pharmacological treatment	0.17
9	Management	60	9	Therapy	0.16
10	Therapy	53	10	Primary care	0.15

Figure 9

Top 15 keywords with the strongest citation bursts. The red bars demonstrated that the keyword was cited frequently, the green bars showed that the keyword was cited infrequently.

Some limitations should be addressed in our study. Firstly, we only analyzed the documents recorded in the Web of Science. Therefore, our findings may not be comprehensive, and it is necessary to perform further analysis of literature in other databases, such as some Chinese databases. In addition, although the research topic had been defined when searching, we cannot guarantee that every document is completely related to the topic. However, we believe that this study can still be used to describe the overall situation and trends in this field.

Conclusion

Acupuncture, as a complementary and alternative therapy, was widely used in patients with KOA, and has the advantages of high safety and fewer side effects. In this study, a large number of publications were published in the journals of Evidence-Based Complementary And Alternative Medicine. The most prolific country was China. However, the most productive institution of publications in this field was the University of York in England, it may reveal the fact that acupuncture as a complementary and alternative therapy to treat patients with KOA was becoming increasingly accepted in the world. In addition, recent results indicated a lack of cooperation between different institutions and countries. Therefore, cooperation and connection between different research teams should be strengthened, which will be beneficial to promote the current opinion of acupuncture pain control in KOA as an alternative method. Moreover, randomized controlled trial is currently the main research method to study acupuncture treatment on KOA. Given that it is difficult to achieve double blinding during acupuncture manipulation, single blind randomized controlled trials are frequently performed to verify the effect of acupuncture for KOA. Meta-analysis was the main methodology to evaluate the efficacy of acupuncture therapy on KOA, but the high-quality evaluation of various acupuncture treatments was inadequate currently, which is need further research by physiotherapists.

In summary, this study provides potential collaborators and institutions, and hot topics, thereby providing a perspective to the developing trend of acupuncture therapy on KOA, which may help researchers explore new directions for future research in this field.