Marie Andersson1, Sofia Sjöström2, Monika Doroszkiewicz3, Lisa Örtqvist4, Kate Abrahamsson5, Ulla Sillén6, Gundela Holmdahl7. 1. Sahlgrenska Academy, Women's and Children's Health, Gothenburg, Sweden; The Pediatric Uro-Nephrologic Center, Department of Pediatric Surgery, Queen Silvia's Children's Hospital, Gothenburg, Sweden. Electronic address: marie.kristina.andersson@vgregion.se. 2. Sahlgrenska Academy, Women's and Children's Health, Gothenburg, Sweden; The Pediatric Uro-Nephrologic Center, Department of Pediatric Surgery, Queen Silvia's Children's Hospital, Gothenburg, Sweden. Electronic address: sofia.sjostrom@vgregion.se. 3. The Pediatric Uro-Nephrologic Center, Department of Pediatric Surgery, Queen Silvia's Children's Hospital, Gothenburg, Sweden. Electronic address: monika.doroszkiewicz@vgregion.se. 4. Department of Women's and Children's Health and Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Pediatric Surgery, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden. Electronic address: elisabet.ortqvist@ki.se. 5. Sahlgrenska Academy, Women's and Children's Health, Gothenburg, Sweden; The Pediatric Uro-Nephrologic Center, Department of Pediatric Surgery, Queen Silvia's Children's Hospital, Gothenburg, Sweden. Electronic address: kate.abrahamsson@vgregion.se. 6. Sahlgrenska Academy, Women's and Children's Health, Gothenburg, Sweden; The Pediatric Uro-Nephrologic Center, Department of Pediatric Surgery, Queen Silvia's Children's Hospital, Gothenburg, Sweden. Electronic address: ulla.sillen@vgregion.se. 7. Sahlgrenska Academy, Women's and Children's Health, Gothenburg, Sweden; The Pediatric Uro-Nephrologic Center, Department of Pediatric Surgery, Queen Silvia's Children's Hospital, Gothenburg, Sweden. Electronic address: gundela.holmdahl@vgregion.se.
Abstract
BACKGROUND: Proximal hypospadias repair is associated with a considerable complication risk. Long-term follow-up is required to present realistic expectations in pre-operative counseling. OBJECTIVE: To investigate adolescents after childhood surgery for proximal hypospadias in a prospective cohort study describing the urological outcome, complication rates and patient satisfaction with penile appearance. STUDY DESIGN: 39 adolescents ≥14 years with penoscrotal to perineal hypospadias and primary urethroplasty (tubularized incised plate (TIP), preputial flap as Onlay or tubularized (Duckett)) from 1996 to 2005 at a single center were evaluated. The clinical assessment, at Md 16.5 years (14-25), included voiding history, genital examination including the Hypospadias Objective Scoring Evaluation (HOSE), uroflowmetry plus chart data from previous urinary flows and evaluation of patient satisfaction using the Penile Perception Score (PPS). RESULTS: Twenty-nine patients with penoscrotal and 10 with scrotal/perineal hypospadias underwent surgery with TIP (N = 14), Onlay (N = 14) and Duckett (N = 11). Uroflows improved significantly compared with prepubertal maximal flows. Impaired flow rate (<10 mL/s) was found in 14% (5/36). Fifty-one percent (20/39) required reoperations, 29% (4/14) of TIP, 50% (7/14) of Onlay and 82% (9/11) of Duckett (p = 0.0062). Median penile length in adolescence was 8.7 cm (4.0-11.0). Forty-four percent (12/27) of patients were dissatisfied with penile length. Patients were 'satisfied' or 'very satisfied' with meatal position and shape despite HOSE for meatal position being 11% (4/38) distal, 76% (29/38) proximal glanular and 13% (5/38) coronal. TIP patients had more curvature at puberty than Duckett (p = 0.0062). Patients that had a decurvature procedure had shorter penile length (p = 0.019). DISCUSSION: A high complication rate is previously described, predominantly within the first years. Our study shows 50% of reoperations were performed after >3 years, illustrating the need for long-term follow-up. Patient satisfaction with a deviant meatal position is rarely reported [1,2]. Our results support a conservative approach to an asymptomatic retracted meatus. Limitations of this descriptive study are the non-comparable groups and the retrospective data for correlation, impeding evaluation of prognostic outcome-factors. The shorter penile length found in patients after plication, and increased curvature after TIP, is therefore merely descriptive. However, the findings are in line with earlier publications suggesting limited use of TIP, and plication (recommending ventral lengthening instead) to avoid penile shortening and curvature in these cases [3-5]. CONCLUSIONS: The urological long-term outcome after proximal hypospadias repair is good, although late reoperations are common. In adolescence, patients were dissatisfied with the short penile length but satisfied with meatal position, indicating that in proximal hypospadias, preserving penile length and correcting curvature are prioritized over a distal meatus.
BACKGROUND: Proximal hypospadias repair is associated with a considerable complication risk. Long-term follow-up is required to present realistic expectations in pre-operative counseling. OBJECTIVE: To investigate adolescents after childhood surgery for proximal hypospadias in a prospective cohort study describing the urological outcome, complication rates and patient satisfaction with penile appearance. STUDY DESIGN: 39 adolescents ≥14 years with penoscrotal to perineal hypospadias and primary urethroplasty (tubularized incised plate (TIP), preputial flap as Onlay or tubularized (Duckett)) from 1996 to 2005 at a single center were evaluated. The clinical assessment, at Md 16.5 years (14-25), included voiding history, genital examination including the Hypospadias Objective Scoring Evaluation (HOSE), uroflowmetry plus chart data from previous urinary flows and evaluation of patient satisfaction using the Penile Perception Score (PPS). RESULTS: Twenty-nine patients with penoscrotal and 10 with scrotal/perineal hypospadias underwent surgery with TIP (N = 14), Onlay (N = 14) and Duckett (N = 11). Uroflows improved significantly compared with prepubertal maximal flows. Impaired flow rate (<10 mL/s) was found in 14% (5/36). Fifty-one percent (20/39) required reoperations, 29% (4/14) of TIP, 50% (7/14) of Onlay and 82% (9/11) of Duckett (p = 0.0062). Median penile length in adolescence was 8.7 cm (4.0-11.0). Forty-four percent (12/27) of patients were dissatisfied with penile length. Patients were 'satisfied' or 'very satisfied' with meatal position and shape despite HOSE for meatal position being 11% (4/38) distal, 76% (29/38) proximal glanular and 13% (5/38) coronal. TIP patients had more curvature at puberty than Duckett (p = 0.0062). Patients that had a decurvature procedure had shorter penile length (p = 0.019). DISCUSSION: A high complication rate is previously described, predominantly within the first years. Our study shows 50% of reoperations were performed after >3 years, illustrating the need for long-term follow-up. Patient satisfaction with a deviant meatal position is rarely reported [1,2]. Our results support a conservative approach to an asymptomatic retracted meatus. Limitations of this descriptive study are the non-comparable groups and the retrospective data for correlation, impeding evaluation of prognostic outcome-factors. The shorter penile length found in patients after plication, and increased curvature after TIP, is therefore merely descriptive. However, the findings are in line with earlier publications suggesting limited use of TIP, and plication (recommending ventral lengthening instead) to avoid penile shortening and curvature in these cases [3-5]. CONCLUSIONS: The urological long-term outcome after proximal hypospadias repair is good, although late reoperations are common. In adolescence, patients were dissatisfied with the short penile length but satisfied with meatal position, indicating that in proximal hypospadias, preserving penile length and correcting curvature are prioritized over a distal meatus.
Authors: Kassie D Flewelling; Stephanie De Jesus Ayala; Yee-Ming Chan; Diane Chen; Saakshi Daswani; Jennifer Hansen-Moore; V Rama Jayanthi; Hillary M Kapa; Leena Nahata; Jaclyn L Papadakis; Keeley Pratt; Joseph R Rausch; Hailey Umbaugh; Vijaya Vemulakonda; Canice E Crerand; Amy C Tishelman; Cindy L Buchanan Journal: J Pediatr Urol Date: 2022-03-08 Impact factor: 1.921