| Literature DB >> 3279996 |
H Usami1, A Yamamoto, W Yamashita, Y Sugawara, S Hamada, T Yamamoto, K Kato, S Kokeguchi, H Ohokuni, S Kotani.
Abstract
The antitumour effects of lipoteichoic acids (LTA) extracted from Streptococcus pyogenes were studied in comparison with other streptococcal cellular components. LTA suppressed the tumour growth of both solid- and ascites-type Meth A fibrosarcoma as did the whole cells of S. pyogenes (OK-432). No other cellular components, such as cell wall peptidoglycan, group-specific C-carbohydrate or type-specific M protein, suppressed the growth of Meth A. LTA, but not the other cellular components, induced tumour necrosis factor (TNF) in Propionibacterium acnes-primed mice. LTA had no direct killing effects on Meth A cells. These results indicate that LTA may be an important antitumour component of OK-432 and that one of the antitumour mechanisms by this streptococcal preparation is the induction of TNF.Entities:
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Year: 1988 PMID： 3279996 PMCID： PMC2246679 DOI： 10.1038/bjc.1988.11
Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640