| Literature DB >> 32799417 |
Pietro Maggi1,2,3, Pascal Sati4,5, Govind Nair4, Irene C M Cortese4, Steven Jacobson4, Bryan R Smith4, Avindra Nath4, Joan Ohayon4, Vincent van Pesch1, Gaetano Perrotta2, Caroline Pot3, Marie Théaudin3, Vittorio Martinelli6, Roberta Scotti7, Tianxia Wu8, Renaud Du Pasquier3, Peter A Calabresi9, Massimo Filippi6, Daniel S Reich4, Martina Absinta9.
Abstract
In multiple sclerosis (MS), a subset of chronic active white matter lesions are identifiable on magnetic resonance imaging by their paramagnetic rims, and increasing evidence supports their association with severity of clinical disease. We studied their potential role in differential diagnosis, screening an international multicenter clinical research-based sample of 438 individuals affected by different neurological conditions (MS, other inflammatory, infectious, and non-inflammatory conditions). Paramagnetic rim lesions, rare in other neurological conditions (52% of MS vs 7% of non-MS cases), yielded high specificity (93%) in differentiating MS from non-MS. Future prospective multicenter studies should validate their role as a diagnostic biomarker. ANN NEUROL 2020;88:1034-1042.Entities:
Mesh：
Year: 2020 PMID： 32799417 DOI： 10.1002/ana.25877
Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422