Alberto Deganello1, Alberto Paderno1, Riccardo Morello2, Milena Fior1, Giulia Berretti1, Francesca Del Bon1, Marco Alparone1, Elena Bardellini3, Alessandra Majorana3, Piero Nicolai4. 1. Unit of Otorhinolaryngology-Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy. 2. Unit of Otorhinolaryngology-Head and Neck Surgery, Department of Surgical Specialties, Cremona, Italy. 3. Dental Clinic, School of Dentistry, University of Brescia, Brescia, Italy. 4. Section of Otorhinolaryngology-Head and Neck Surgery, Department of Neurosciences, University of Padua, Padua, Italy.
Abstract
OBJECTIVE: Oral lichen planus (OLP) is a chronic mucocutaneous immune-mediated disease affecting 1% to 4% of the worldwide population. Development of malignant lesions is reported but only affects a minority of patients. The aim of our study was to assess the diagnostic potential of narrow band imaging (NBI) in OLP patients; focusing on the identification of high-grade dysplasia/carcinoma in newly developed lesions. METHODS: Prospective evaluation of 56 patients with histopathologic diagnosis of OLP and presenting newly developed lesions not responding to medical treatment. All lesions were assessed by high-definition (HD) white light (WL) and HD-NBI endoscopy. All patients underwent biopsy regardless of the appearance at HD-WL and HD-NBI. Histology was defined as "positive" in case of high-grade dysplasia or carcinoma. RESULTS: Five lesions (9%) were diagnosed as high-grade dysplasia/carcinoma. In this setting, overall diagnostic potential of HD-NBI was optimal, with a sensitivity of 100% (95% CI, 48-100), specificity of 96% (95% CI, 86-99), negative predictive value of 100% (95% CI, not calculable), positive predictive value of 71% (95% CI, 39-91), and accuracy of 96% (95% CI, 88-100). CONCLUSIONS: Despite the diffuse inflammatory pattern derived from OLP, NBI improved the diagnostic accuracy and the capability to detect high-grade dysplasia/carcinoma. LEVEL OF EVIDENCE: 4 Laryngoscope, 131:E1156-E1161, 2021.
OBJECTIVE:Oral lichen planus (OLP) is a chronic mucocutaneous immune-mediated disease affecting 1% to 4% of the worldwide population. Development of malignant lesions is reported but only affects a minority of patients. The aim of our study was to assess the diagnostic potential of narrow band imaging (NBI) in OLP patients; focusing on the identification of high-grade dysplasia/carcinoma in newly developed lesions. METHODS: Prospective evaluation of 56 patients with histopathologic diagnosis of OLP and presenting newly developed lesions not responding to medical treatment. All lesions were assessed by high-definition (HD) white light (WL) and HD-NBI endoscopy. All patients underwent biopsy regardless of the appearance at HD-WL and HD-NBI. Histology was defined as "positive" in case of high-grade dysplasia or carcinoma. RESULTS: Five lesions (9%) were diagnosed as high-grade dysplasia/carcinoma. In this setting, overall diagnostic potential of HD-NBI was optimal, with a sensitivity of 100% (95% CI, 48-100), specificity of 96% (95% CI, 86-99), negative predictive value of 100% (95% CI, not calculable), positive predictive value of 71% (95% CI, 39-91), and accuracy of 96% (95% CI, 88-100). CONCLUSIONS: Despite the diffuse inflammatory pattern derived from OLP, NBI improved the diagnostic accuracy and the capability to detect high-grade dysplasia/carcinoma. LEVEL OF EVIDENCE: 4 Laryngoscope, 131:E1156-E1161, 2021.
Authors: Muhammad Adeel Azam; Claudio Sampieri; Alessandro Ioppi; Pietro Benzi; Giorgio Gregory Giordano; Marta De Vecchi; Valentina Campagnari; Shunlei Li; Luca Guastini; Alberto Paderno; Sara Moccia; Cesare Piazza; Leonardo S Mattos; Giorgio Peretti Journal: Front Oncol Date: 2022-06-01 Impact factor: 5.738
Authors: Francesco Missale; Stefano Taboni; Cesare Piazza; Giorgio Peretti; Andrea Luigi Camillo Carobbio; Francesco Mazzola; Giulia Berretti; Andrea Iandelli; Marco Fragale; Francesco Mora; Alberto Paderno; Francesca Del Bon; Giampiero Parrinello; Alberto Deganello Journal: Eur Arch Otorhinolaryngol Date: 2021-03-12 Impact factor: 2.503
Authors: Alberto Paderno; Cesare Piazza; Francesca Del Bon; Davide Lancini; Stefano Tanagli; Alberto Deganello; Giorgio Peretti; Elena De Momi; Ilaria Patrini; Michela Ruperti; Leonardo S Mattos; Sara Moccia Journal: Front Oncol Date: 2021-03-24 Impact factor: 6.244