| Literature DB >> 32796958 |
Yuxing Zhu1, Jingjing Li1,2, Hao Bo3,4, Dong He5, Mengqing Xiao1, Liang Xiang1, Lian Gong1, Yi Hu1, Yeyu Zhang1, Yaxin Cheng1, Liping Deng1, Rongrong Zhu1, Yanni Ma1, Ke Cao6.
Abstract
The long non-coding RNA (LncRNA) abnormally expresses in several cancers including non-small cell lung cancer (NSCLC). To better understand the role of key lncRNA involving cancer progress, we conduct a comprehensive data mining on LINC00467 and determine its molecular mechanisms. We identified LINC00467 was the up-regulated lncRNA that common significantly differentially expressed in NSCLC and CRC tissues from GEO database. LINC00467 highly expressed in NSCLC tissues and associated with advanced clinical stages and poor outcome. Knockdown of LINC00467 inhibited cell growth and metastasis via regulating the Akt signaling pathway. Finally, we demonstrated that TDG mediated acetylation is the key factor controlling LINC00467 expression. In conclusion, LINC00467 promotes NSCLC progression via Akt signal pathway. The identified LINC00467 may serve as a valuable diagnostic and prognostic biomarker as well as a therapeutic target for NSCLC.Entities:
Mesh：
Substances：
Year: 2020 PMID： 32796958 DOI： 10.1038/s41388-020-01421-w
Source DB: PubMed Journal: Oncogene ISSN： 0950-9232 Impact factor: 9.867