JingXing Xiao1,2, Dong Wang2, Bin Guo1, Lu Wang1, Min Su2, Hao Xu1. 1. Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou. 2. Department of Nuclear Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Abstract
OBJECTIVES: To evaluate the interobserver agreement and the diagnostic performance in F-sodium fluoride (F-NaF) PET/computed tomography (CT) for the detection of skull-base bone invasion (SBBI) and osseous metastases in patients with newly diagnosed nasopharyngeal carcinoma (NPC). METHODS: One hundred seventeen patients with newly diagnosed NPC between 2017 and 2019 who underwent F-NaF PET/CT was in included. Two experienced observers independently evaluated the F-NaF PET/CT of SBBI and osseous metastases on a patient level using a two-category scale present on a dichotomous scale, respectively. On a patient level, the diagnostic performance was calculated using a sensitivity analysis. RESULTS: The interobserver agreement on a patient level of SBBI and osseous metastases were perfect on a patient-level (κ: 0.85), (κ: 0.808), respectively. On a lesion level of detection of osseous metastases, the observers agreed on the number as well as the location of osseous metastases in 101 (86.3%) patients. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of detection of SBBI and osseous metastases were ranged 0.911-0.962, 0.921-0.974, 0.932-0.957, 0.962-0.986, and 0.841-0.923, and ranged 0.917-0.958, 0.899-0.957, 0.906-0.949, 0.863-0.936, and 0.939-0.970, respectively. CONCLUSION: The interobserver agreement of F-NaF PET/CT for the detection of SBBI and osseous metastases in patients with NPC were both very high among trained observers. Moreover, the diagnostic performance of NaF PET/CT was satisfactory, rendering NaF PET/CT a robust tool in the diagnostic armamentarium.
OBJECTIVES: To evaluate the interobserver agreement and the diagnostic performance in F-sodium fluoride (F-NaF) PET/computed tomography (CT) for the detection of skull-base bone invasion (SBBI) and osseous metastases in patients with newly diagnosed nasopharyngeal carcinoma (NPC). METHODS: One hundred seventeen patients with newly diagnosed NPC between 2017 and 2019 who underwent F-NaF PET/CT was in included. Two experienced observers independently evaluated the F-NaF PET/CT of SBBI and osseous metastases on a patient level using a two-category scale present on a dichotomous scale, respectively. On a patient level, the diagnostic performance was calculated using a sensitivity analysis. RESULTS: The interobserver agreement on a patient level of SBBI and osseous metastases were perfect on a patient-level (κ: 0.85), (κ: 0.808), respectively. On a lesion level of detection of osseous metastases, the observers agreed on the number as well as the location of osseous metastases in 101 (86.3%) patients. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of detection of SBBI and osseous metastases were ranged 0.911-0.962, 0.921-0.974, 0.932-0.957, 0.962-0.986, and 0.841-0.923, and ranged 0.917-0.958, 0.899-0.957, 0.906-0.949, 0.863-0.936, and 0.939-0.970, respectively. CONCLUSION: The interobserver agreement of F-NaF PET/CT for the detection of SBBI and osseous metastases in patients with NPC were both very high among trained observers. Moreover, the diagnostic performance of NaF PET/CT was satisfactory, rendering NaF PET/CT a robust tool in the diagnostic armamentarium.