AIM: Malignant peripheral nerve sheath tumors (MPNSTs) are rare tumors arising from a peripheral nerve or in extraneural soft tissue which shows high metastatic potential and poor prognosis. They can arise de-novo or through malignant transformation in neurofibromatosis (NF-1). The purpose of our study is to evaluate potential role of fluorodeoxyglucose (FDG) PET/computed tomography (CT) in prognostication and management of MPNSTs. MATERIALS AND METHODS: We have performed a retrospective analysis in patients of MPNSTs who underwent F-FDG PET/CT imaging for staging and restaging. Standardized uptake values (SUVmax and SUVmean) and texture parameters (calculated using radiomics package version 0.1.3) were measured for primary/recurrent lesions and were compared between two groups based on presence of event (recurrence/progression). Student t-test was applied for comparative analyses using the SPSS software package (version 23.0; IBM), with a significance level of 0.05. RESULTS: Thirty patients (17 male, 13 female; mean age 42.7 ± 15.66 years) were included, who underwent F-FDG PET/CT for staging (n = 10) and restaging (n = 20). Change in management was observed in four patients at baseline and in three patients in follow-up imaging for response assessment, who had progressive disease which prompted treatment intensification. SUVmax of primary/recurrent lesion showed correlation with histopathologic grade (r = 0.712, P = 0.034). Textural analysis showed more heterogeneity in lesions in the high-risk group with recurrence and progression. CONCLUSION: F-FDG PET/CT can be used for staging and restaging in MPNSTs leading to change in management. Texture analysis and quantitative F-FDG PET/CT parameters can help in prognostication at both baseline and relapse.
AIM: Malignant peripheral nerve sheath tumors (MPNSTs) are rare tumors arising from a peripheral nerve or in extraneural soft tissue which shows high metastatic potential and poor prognosis. They can arise de-novo or through malignant transformation in neurofibromatosis (NF-1). The purpose of our study is to evaluate potential role of fluorodeoxyglucose (FDG) PET/computed tomography (CT) in prognostication and management of MPNSTs. MATERIALS AND METHODS: We have performed a retrospective analysis in patients of MPNSTs who underwent F-FDG PET/CT imaging for staging and restaging. Standardized uptake values (SUVmax and SUVmean) and texture parameters (calculated using radiomics package version 0.1.3) were measured for primary/recurrent lesions and were compared between two groups based on presence of event (recurrence/progression). Student t-test was applied for comparative analyses using the SPSS software package (version 23.0; IBM), with a significance level of 0.05. RESULTS: Thirty patients (17 male, 13 female; mean age 42.7 ± 15.66 years) were included, who underwent F-FDG PET/CT for staging (n = 10) and restaging (n = 20). Change in management was observed in four patients at baseline and in three patients in follow-up imaging for response assessment, who had progressive disease which prompted treatment intensification. SUVmax of primary/recurrent lesion showed correlation with histopathologic grade (r = 0.712, P = 0.034). Textural analysis showed more heterogeneity in lesions in the high-risk group with recurrence and progression. CONCLUSION:F-FDG PET/CT can be used for staging and restaging in MPNSTs leading to change in management. Texture analysis and quantitative F-FDG PET/CT parameters can help in prognostication at both baseline and relapse.