Gregory J Grosicki1, Bryan L Riemann2, Andrew A Flatt2, Taylor Valentino3, Michael S Lustgarten4. 1. Biodynamics and Human Performance Center, Georgia Southern University (Armstrong Campus), Savannah, GA, USA. Electronic address: ggrosicki@georgiasouthern.edu. 2. Biodynamics and Human Performance Center, Georgia Southern University (Armstrong Campus), Savannah, GA, USA. 3. Department of Physiology, University of Kentucky, Lexington, KY, USA. 4. Nutrition, Exercise Physiology and Sarcopenia (NEPS) Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA), Tufts University, Boston, MA, USA.
Abstract
OBJECTIVES: The microbiota-gut-brain axis is an intricate communication network that is emerging as a key modulator of psychological and physiological wellbeing. Recent pioneering work in the field has suggested a possible link between gut microbiome composition with sleep, an evolutionarily conserved behavior demonstrated to play a critical role in health. This study is the first to address relationships between self-reported sleep habits and gut microbiome composition in young, healthy individuals. METHODS: A total of 28 young, healthy subjects (17 males/11 females; 29.8 ± 10.4 years) that were free of metabolic or cardiovascular disease, and that did not take sleep medication or antibiotics within the past six months were included in the study. Relationships between self-reported sleep quality, obtained using the Pittsburgh Sleep Quality Index (PSQI), with microbial diversity (Shannon Index), the Firmicutes/Bacteroidetes (F/B) ratio, and select bacterial taxa were assessed. RESULTS: Alpha diversity (r = -0.50) and F/B ratio (r = -0.47) were inversely associated (P < 0.05) with the PSQI score. Ten bacterial taxa were associated (P < 0.05) with the PSQI score, including genus-level Blautia (r = -0.57), Ruminococcus (r = -0.39), and Prevotella (r = 0.39). CONCLUSIONS: In young healthy individuals, self-reported sleep quality was positively associated with microbial diversity. We also observed a positive association between sleep quality with F/B ratio, seemingly due to a greater relative abundance of Blautia and Ruminococcus (Firmicutes) and lower proportions of Prevotella (Bacteroidetes) in individuals reporting superior sleep quality. Future studies are encouraged to evaluate mechanistic links between the gut microbiome with sleep, as well as the health implications of this relationship.
OBJECTIVES: The microbiota-gut-brain axis is an intricate communication network that is emerging as a key modulator of psychological and physiological wellbeing. Recent pioneering work in the field has suggested a possible link between gut microbiome composition with sleep, an evolutionarily conserved behavior demonstrated to play a critical role in health. This study is the first to address relationships between self-reported sleep habits and gut microbiome composition in young, healthy individuals. METHODS: A total of 28 young, healthy subjects (17 males/11 females; 29.8 ± 10.4 years) that were free of metabolic or cardiovascular disease, and that did not take sleep medication or antibiotics within the past six months were included in the study. Relationships between self-reported sleep quality, obtained using the Pittsburgh Sleep Quality Index (PSQI), with microbial diversity (Shannon Index), the Firmicutes/Bacteroidetes (F/B) ratio, and select bacterial taxa were assessed. RESULTS: Alpha diversity (r = -0.50) and F/B ratio (r = -0.47) were inversely associated (P < 0.05) with the PSQI score. Ten bacterial taxa were associated (P < 0.05) with the PSQI score, including genus-level Blautia (r = -0.57), Ruminococcus (r = -0.39), and Prevotella (r = 0.39). CONCLUSIONS: In young healthy individuals, self-reported sleep quality was positively associated with microbial diversity. We also observed a positive association between sleep quality with F/B ratio, seemingly due to a greater relative abundance of Blautia and Ruminococcus (Firmicutes) and lower proportions of Prevotella (Bacteroidetes) in individuals reporting superior sleep quality. Future studies are encouraged to evaluate mechanistic links between the gut microbiome with sleep, as well as the health implications of this relationship.
Authors: Robert R Jenq; Ying Taur; Sean M Devlin; Doris M Ponce; Jenna D Goldberg; Katya F Ahr; Eric R Littmann; Lilan Ling; Asia C Gobourne; Liza C Miller; Melissa D Docampo; Jonathan U Peled; Nicholas Arpaia; Justin R Cross; Tatanisha K Peets; Melissa A Lumish; Yusuke Shono; Jarrod A Dudakov; Hendrik Poeck; Alan M Hanash; Juliet N Barker; Miguel-Angel Perales; Sergio A Giralt; Eric G Pamer; Marcel R M van den Brink Journal: Biol Blood Marrow Transplant Date: 2015-05-11 Impact factor: 5.742
Authors: Valeriy A Poroyko; Alba Carreras; Abdelnaby Khalyfa; Ahamed A Khalyfa; Vanessa Leone; Eduard Peris; Isaac Almendros; Alex Gileles-Hillel; Zhuanhong Qiao; Nathaniel Hubert; Ramon Farré; Eugene B Chang; David Gozal Journal: Sci Rep Date: 2016-10-14 Impact factor: 4.379
Authors: Robert P Smith; Cole Easson; Sarah M Lyle; Ritishka Kapoor; Chase P Donnelly; Eileen J Davidson; Esha Parikh; Jose V Lopez; Jaime L Tartar Journal: PLoS One Date: 2019-10-07 Impact factor: 3.240
Authors: Dana Withrow; Samuel J Bowers; Christopher M Depner; Antonio González; Amy C Reynolds; Kenneth P Wright Journal: Curr Opin Endocr Metab Res Date: 2020-11-28