Literature DB >> 3279570

Staphylococcal alpha toxin--recent advances.

M Thelestam1, L Blomqvist.   

Abstract

The elucidation of the amino acid sequence of alpha toxin in 1984 has greatly promoted our understanding of the basic biochemistry and interaction of this toxin with membranes. These aspects are discussed and the concept of alpha toxin as a channel forming protein is critically evaluated. The lethal action of alpha toxin has not yet been clarified, but the previously postulated action as a neurotoxin is not supported by recent observations.

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Year:  1988        PMID: 3279570     DOI: 10.1016/0041-0101(88)90137-7

Source DB:  PubMed          Journal:  Toxicon        ISSN: 0041-0101            Impact factor:   3.033


  20 in total

Review 1.  Advances in small animal mesentery models for in vivo flow cytometry, dynamic microscopy, and drug screening.

Authors:  Ekaterina I Galanzha; Valery V Tuchin; Vladimir P Zharov
Journal:  World J Gastroenterol       Date:  2007-01-14       Impact factor: 5.742

2.  Modification of lysine residues of Staphylococcus aureus alpha-toxin: effects on its channel-forming properties.

Authors:  L Cescatti; C Pederzolli; G Menestrina
Journal:  J Membr Biol       Date:  1991-01       Impact factor: 1.843

3.  Cytotoxic activities of Leptospira interrogans hemolysin SphH as a pore-forming protein on mammalian cells.

Authors:  Seoung Hoon Lee; Sangduk Kim; Seung Chul Park; Min Ja Kim
Journal:  Infect Immun       Date:  2002-01       Impact factor: 3.441

4.  Inhibition of S. aureus alpha-hemolysin and B. anthracis lethal toxin by beta-cyclodextrin derivatives.

Authors:  Vladimir A Karginov; Ekaterina M Nestorovich; Frank Schmidtmann; Tanisha M Robinson; Adiamseged Yohannes; Nour Eddine Fahmi; Sergey M Bezrukov; Sidney M Hecht
Journal:  Bioorg Med Chem       Date:  2007-05-26       Impact factor: 3.641

5.  Corneal virulence of Staphylococcus aureus: roles of alpha-toxin and protein A in pathogenesis.

Authors:  M C Callegan; L S Engel; J M Hill; R J O'Callaghan
Journal:  Infect Immun       Date:  1994-06       Impact factor: 3.441

6.  Protonation dynamics of the alpha-toxin ion channel from spectral analysis of pH-dependent current fluctuations.

Authors:  J J Kasianowicz; S M Bezrukov
Journal:  Biophys J       Date:  1995-07       Impact factor: 4.033

7.  Induction of muscle-relaxing factor by staphylococcal alpha-toxin.

Authors:  S Harshman; N Sugg
Journal:  Infect Immun       Date:  1994-02       Impact factor: 3.441

8.  Site-directed mutagenesis of the alpha-toxin gene of Staphylococcus aureus: role of histidines in toxin activity in vitro and in a murine model.

Authors:  B E Menzies; D S Kernodle
Journal:  Infect Immun       Date:  1994-05       Impact factor: 3.441

9.  The accessory gene regulator (agr) controls Staphylococcus aureus virulence in a murine arthritis model.

Authors:  A Abdelnour; S Arvidson; T Bremell; C Rydén; A Tarkowski
Journal:  Infect Immun       Date:  1993-09       Impact factor: 3.441

Review 10.  Alpha-toxin of Staphylococcus aureus.

Authors:  S Bhakdi; J Tranum-Jensen
Journal:  Microbiol Rev       Date:  1991-12
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