OBJECTIVE: To summarize the research progress of adipose-derived stem cells (ADSCs) in promoting the repair of peripheral nerve injury. METHODS: The related literature at home and abroad in recent years was widely reviewed, the mechanism of ADSCs promoting the repair of peripheral nerve injury was introduced, and its basic research progress was analyzed and summarized. Finally, the clinical transformation application of ADSCs in the treatment of peripheral nerve injury was introduced, the existing problems were pointed out, and the new treatment regimen was prospected. RESULTS: ADSCs have the function of differentiation and paracrine, and their secreted neurotrophic factors, antiapoptosis, and antioxidant factors can promote the repair of peripheral nerve injury. CONCLUSION: ADSCs are rich in content and easy to obtain, which has a definite effectiveness on the repair of peripheral nerve injury with potential clinical prospect.
OBJECTIVE: To summarize the research progress of adipose-derived stem cells (ADSCs) in promoting the repair of peripheral nerve injury. METHODS: The related literature at home and abroad in recent years was widely reviewed, the mechanism of ADSCs promoting the repair of peripheral nerve injury was introduced, and its basic research progress was analyzed and summarized. Finally, the clinical transformation application of ADSCs in the treatment of peripheral nerve injury was introduced, the existing problems were pointed out, and the new treatment regimen was prospected. RESULTS: ADSCs have the function of differentiation and paracrine, and their secreted neurotrophic factors, antiapoptosis, and antioxidant factors can promote the repair of peripheral nerve injury. CONCLUSION: ADSCs are rich in content and easy to obtain, which has a definite effectiveness on the repair of peripheral nerve injury with potential clinical prospect.
Authors: Michele Riccio; Andrea Marchesini; Pierfrancesco Pugliese; Francesco De Francesco Journal: J Cell Physiol Date: 2018-09-12 Impact factor: 6.384