Panagiotis Paliogiannis1, Angelo Zinellu2, Valentina Scano3, Giulia Mulas4, Giacomo De Riu5, Rosa M Pascale6, Luigi B Arru7, Ciriaco Carru8, Pietro Pirina9, Arduino A Mangoni10, Alessandro G Fois11. 1. Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy. ppaliogiannis@uniss.it. 2. Department of Biomedical Sciences, University of Sassari, Sassari, Italy. azinellu@uniss.it. 3. Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy. valescano93@gmail.com. 4. Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy. giulia_mulas@hotmail.it. 5. Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy. gderiu@uniss.it. 6. Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy. patsper@uniss.it. 7. Operative Unit of Hematology, Center for Stem Cell Transplantation, San Francesco Hospital, Nuoro, Italy. 8. Department of Biomedical Sciences, University of Sassari, Sassari, Italy. carru@uniss.it. 9. Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy. pirina@uniss.it. 10. Department of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Adelaide, Australia. arduino.mangoni@flinders.edu.au. 11. Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy. agfois@uniss.it.
Abstract
INTRODUCTION: Coronavirus disease 19 (COVID-19) is the greatest pandemic in modern history. Laboratory test alterations have been described in COVID-19 patients, but differences with other pneumonias have been poorly investigated to date, especially in Caucasian populations. The aim of this study was to investigate differences and prognostic potential of routine blood tests in a series of Italian patients with COVID-19 and non-COVID-19 interstitial pneumonia. METHODOLOGY: Clinical data and routine laboratory tests of a consecutive series of 30 COVID-19 patients and 30 age and sex matched patients with non COVID-19 interstitial pneumonia have been retrospectively collected. Differences in laboratory tests between patients with COVID-19 and non COVID-19 pneumonias have been investigated, as well as differences between COVID-19 survivors and non survivors. RESULTS: COVID-19 patients had lower white blood cells, monocytes, neutrophils, and higher platelet counts. In addition, COVID-19 patients showed higher mean platelet volume, lower C reactive protein concentrations, and higher De Ritis ratio. Combined blood cell indexes of systemic inflammation were significantly lower in COVID-19 patients. In further analysis of the COVID-19 group, the neutrophil count, neutrophil to lymphocyte ratio (NLR), derived NLR, systemic inflammation response index and De Ritis ratio, were significantly higher in non survivors than in survivors, while the number of platelets was significantly lower in non survivors. CONCLUSIONS: Our study showed several alterations in blood cell populations and indexes in patients with COVID-19 pneumonia in comparison with patients with non COVID-19 pneumonia. Some of these indexes showed promising prognostic abilities. Further studies are necessary to confirm these results. Copyright (c) 2020 Panagiotis Paliogiannis, Angelo Zinellu, Valentina Scano, Giulia Mulas, Giacomo De Riu, Rosa M Pascale, Luigi B Arru, Ciriaco Carru, Pietro Pirina, Arduino A Mangoni, Alessandro G Fois.
INTRODUCTION:Coronavirus disease 19 (COVID-19) is the greatest pandemic in modern history. Laboratory test alterations have been described in COVID-19patients, but differences with other pneumonias have been poorly investigated to date, especially in Caucasian populations. The aim of this study was to investigate differences and prognostic potential of routine blood tests in a series of Italian patients with COVID-19 and non-COVID-19 interstitial pneumonia. METHODOLOGY: Clinical data and routine laboratory tests of a consecutive series of 30 COVID-19patients and 30 age and sex matched patients with non COVID-19 interstitial pneumonia have been retrospectively collected. Differences in laboratory tests between patients with COVID-19 and non COVID-19 pneumonias have been investigated, as well as differences between COVID-19 survivors and non survivors. RESULTS:COVID-19patients had lower white blood cells, monocytes, neutrophils, and higher platelet counts. In addition, COVID-19patients showed higher mean platelet volume, lower C reactive protein concentrations, and higher De Ritis ratio. Combined blood cell indexes of systemic inflammation were significantly lower in COVID-19patients. In further analysis of the COVID-19 group, the neutrophil count, neutrophil to lymphocyte ratio (NLR), derived NLR, systemic inflammation response index and De Ritis ratio, were significantly higher in non survivors than in survivors, while the number of platelets was significantly lower in non survivors. CONCLUSIONS: Our study showed several alterations in blood cell populations and indexes in patients with COVID-19 pneumonia in comparison with patients with non COVID-19 pneumonia. Some of these indexes showed promising prognostic abilities. Further studies are necessary to confirm these results. Copyright (c) 2020 Panagiotis Paliogiannis, Angelo Zinellu, Valentina Scano, Giulia Mulas, Giacomo De Riu, Rosa M Pascale, Luigi B Arru, Ciriaco Carru, Pietro Pirina, Arduino A Mangoni, Alessandro G Fois.
Authors: Angelo Zinellu; Elisabetta Zinellu; Maria Carmina Pau; Ciriaco Carru; Pietro Pirina; Alessandro G Fois; Arduino A Mangoni Journal: J Clin Med Date: 2022-06-11 Impact factor: 4.964
Authors: Raymond Pranata; Ian Huang; Michael Anthonius Lim; Emir Yonas; Rachel Vania; Antonia Anna Lukito; Sally Aman Nasution; Bambang Budi Siswanto; Raden A Tuty Kuswardhani Journal: Front Med (Lausanne) Date: 2021-12-22