| Literature DB >> 3279210 |
R E TenBrink1, D T Pals, D W Harris, G A Johnson.
Abstract
Renin inhibitors 2-4 with the D-Lys renin inhibitory peptide (RIP) sequence, but containing Leu psi[CH2O]Ala (2), Leu psi[CH2O]Val (3), and Leu psi[CH2O]Leu (4) at the P1-P1' site, were of a comparable potency to RIP. N-Terminal Boc-protected inhibitors containing Pro psi[CH2O]Phe in positions P4-P3 were potent inhibitors of renin, with Boc-Phe-Pro psi[CH2O]Phe-His-Leu psi[CH(OH)CH2]Val-Ile-(2-aminomethyl) pyridine (17) having an IC50 of 1.6 X 10(-9) M.Entities:
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Year: 1988 PMID： 3279210 DOI： 10.1021/jm00398a029
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446