Literature DB >> 32791750

Association of the CDKAL1 polymorphism rs10946398 with type 2 diabetes mellitus in adults: A meta-analysis.

Xuekui Liu1, Jun Liang1,2, Houfa Geng1,2, Wei Xu1,2, Fei Teng1,2, Manqing Yang1,2.   

Abstract

Previous studies had reported that the CDKAL1 (cyclin-dependent kinase 5 (CDK5) regulatory subunit-associated protein 1-like 1) rs10946398 C/A polymorphism associated with type 2 diabetes mellitus (T2DM) in various ethnic groups, however, inconsistent results have been obtained in studies of different populations.We performed a meta-analysis of 13 studies for rs10946398 of CDKAL1 on genetic susceptibility for T2DM.The results showed that CDKAL1 rs10946398 C/A polymorphism associated with T2DM under allelic (odds risk (OR): 1.17, 95% CI: 1.07-1.28, P = .0007), homozygous (OR: 1.39, 95% CI: 1.15-1.69, P = .0008), and dominant models (OR: 1.26, 95% CI: 1.09-1.46, P = .001).We found that rs10946398 C/A polymorphism was associated with T2DM, and this association was significantly in population of western country (Europe and United States) and Asian populations.

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Year:  2020        PMID： 32791750      PMCID： PMC7387030          DOI： 10.1097/MD.0000000000021383

Source DB:  PubMed          Journal:  Medicine (Baltimore)        ISSN： 0025-7974            Impact factor:   1.817


  26 in total

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Authors:  Lei Chen; Dianna J Magliano; Paul Z Zimmet
Journal:  Nat Rev Endocrinol       Date:  2011-11-08       Impact factor: 43.330

2.  Cdk5-dependent regulation of glucose-stimulated insulin secretion.

Authors:  Fan-Yan Wei; Kazuaki Nagashima; Toshio Ohshima; Yasunori Saheki; Yun-Fei Lu; Masayuki Matsushita; Yuichiro Yamada; Katsuhiko Mikoshiba; Yutaka Seino; Hideki Matsui; Kazuhito Tomizawa
Journal:  Nat Med       Date:  2005-09-11       Impact factor: 53.440

3.  Positive association between variations in CDKAL1 and type 2 diabetes in Han Chinese individuals.

Authors:  Y Liu; L Yu; D Zhang; Z Chen; D Z Zhou; T Zhao; S Li; T Wang; X Hu; G Y Feng; Z F Zhang; L He; H Xu
Journal:  Diabetologia       Date:  2008-09-03       Impact factor: 10.122

4.  Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies.

Authors:  C Herder; W Rathmann; K Strassburger; H Finner; H Grallert; C Huth; C Meisinger; C Gieger; S Martin; G Giani; W A Scherbaum; H-E Wichmann; T Illig
Journal:  Horm Metab Res       Date:  2008-07-02       Impact factor: 2.936

5.  The association analysis polymorphism of CDKAL1 and diabetic retinopathy in Chinese Han population.

Authors:  Nai-Jia Liu; Qian Xiong; Hui-Hui Wu; Yan-Liang Li; Zhen Yang; Xiao-Ming Tao; Yan-Ping Du; Bin Lu; Ren-Ming Hu; Xuan-Chun Wang; Jie Wen
Journal:  Int J Ophthalmol       Date:  2016-05-18       Impact factor: 1.779

6.  The carriage of risk variants of CDKAL1 impairs beta-cell function in both diabetic and non-diabetic patients and reduces response to non-sulfonylurea and sulfonylurea agonists of the pancreatic KATP channel.

Authors:  Dimitry A Chistiakov; V A Potapov; S A Smetanina; L N Bel'chikova; L A Suplotova; V V Nosikov
Journal:  Acta Diabetol       Date:  2011-05-25       Impact factor: 4.280

7.  Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.

Authors:  Xueyao Han; Yingying Luo; Qian Ren; Xiuying Zhang; Fang Wang; Xiuqin Sun; Xianghai Zhou; Linong Ji
Journal:  BMC Med Genet       Date:  2010-05-28       Impact factor: 2.103

8.  Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.

Authors:  Eun Seok Kang; Myoung Soo Kim; Chul Hoon Kim; Chung Mo Nam; Seung Jin Han; Kyu Yeon Hur; Chul Woo Ahn; Bong Soo Cha; Soon Il Kim; Hyun Chul Lee; Yu Seun Kim
Journal:  Transplantation       Date:  2009-09-15       Impact factor: 4.939

9.  Genetic risk assessment of type 2 diabetes-associated polymorphisms in African Americans.

Authors:  Jessica N Cooke; Maggie C Y Ng; Nicholette D Palmer; S Sandy An; Jessica M Hester; Barry I Freedman; Carl D Langefeld; Donald W Bowden
Journal:  Diabetes Care       Date:  2012-02       Impact factor: 19.112

10.  PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.

Authors:  Cheng Hu; Rong Zhang; Congrong Wang; Jie Wang; Xiaojing Ma; Jingyi Lu; Wen Qin; Xuhong Hou; Chen Wang; Yuqian Bao; Kunsan Xiang; Weiping Jia
Journal:  PLoS One       Date:  2009-10-28       Impact factor: 3.240
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  2 in total

1.  Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge between circadian rhythm and glucose metabolism, in a Turkish population.

Authors:  Hilal Arikoglu; Dudu Erkoc-Kaya; Suleyman Hilmi Ipekci; Fatma Gokturk; Funda Iscioglu; Muslu Kazim Korez; Suleyman Baldane; Mustafa Sait Gonen
Journal:  Mol Biol Rep       Date:  2021-06-11       Impact factor: 2.316

Review 2.  Association of CDKAL1 RS10946398 Gene Polymorphism with Susceptibility to Diabetes Mellitus Type 2: A Meta-Analysis.

Authors:  Ning Xu; Ting-Ting Zhang; Wen-Jia Han; Li-Ping Yin; Nan-Zheng Ma; Xiu-Yan Shi; Jiang-Jie Sun
Journal:  J Diabetes Res       Date:  2021-12-24       Impact factor: 4.011
  2 in total

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