Literature DB >> 3279108

Low C3 in cirrhotic ascites predisposes to spontaneous bacterial peritonitis.

J Such1, C Guarner, J Enriquez, J L Rodriguez, I Seres, F Vilardell.   

Abstract

The risk of developing spontaneous bacterial peritonitis (SBP) in relation to the concentration of C3 in ascitic fluid (AF) has been studied prospectively in 33 patients with cirrhosis of the liver, seven of whom had one or more episodes of SBP during hospitalization. C3 concentrations in the AF of patients who developed infection (9.0 +/- 2.67 mg/dl) were significantly lower than in those who did not (18.26 +/- 8.11 mg/dl) (P less than 0.01). C4 concentrations were similar in both groups. A direct correlation was found between AF C3 and total protein concentrations (P less than 0.001). We conclude that a low C3 concentration in AF may predispose to SBP.

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Year:  1988        PMID： 3279108     DOI： 10.1016/s0168-8278(88)80465-3

Source DB:  PubMed          Journal:  J Hepatol        ISSN： 0168-8278            Impact factor:   25.083


  17 in total

Review 1.  Spontaneous bacterial peritonitis: The clinical challenge of a leaky gut and a cirrhotic liver.

Authors:  Philipp Lutz; Hans Dieter Nischalke; Christian P Strassburg; Ulrich Spengler
Journal:  World J Hepatol       Date:  2015-03-27

2.  Tumor necrosis factor-alpha, interleukin-6, and nitric oxide in sterile ascitic fluid and serum from patients with cirrhosis who subsequently develop ascitic fluid infection.

Authors:  J Such; D J Hillebrand; C Guarner; L Berk; P Zapater; J Westengard; C Peralta; G Soriano; J Pappas; B A Runyon
Journal:  Dig Dis Sci       Date:  2001-11       Impact factor: 3.199

3.  Acquired C3 deficiency in patients with alcoholic cirrhosis predisposes to infection and increased mortality.

Authors:  C Homann; K Varming; K Høgåsen; T E Mollnes; N Graudal; A C Thomsen; P Garred
Journal:  Gut       Date:  1997-04       Impact factor: 23.059

4.  Spontaneous bacterial peritonitis complicating malignancy-related ascites.

Authors:  D V Bac; S de Marie; M van Blankenstein
Journal:  Dig Dis Sci       Date:  1996-01       Impact factor: 3.199

Review 5.  Spontaneous bacterial peritonitis: from pathophysiology to prevention.

Authors:  Mauro Bernardi
Journal:  Intern Emerg Med       Date:  2010-10       Impact factor: 3.397

6.  Bacterial DNA induces the complement system activation in serum and ascitic fluid from patients with advanced cirrhosis.

Authors:  Rubén Francés; José M González-Navajas; Pedro Zapater; Carlos Muñoz; Rocío Caño; Sonia Pascual; Dorkas Márquez; Francia Santana; Miguel Pérez-Mateo; José Such
Journal:  J Clin Immunol       Date:  2007-04-03       Impact factor: 8.317

7.  Activation of the classical complement pathway in spontaneous bacterial peritonitis.

Authors:  G Bird; G Senaldi; M Panos; N Rolando; G Alexander; D Vergani; R Williams
Journal:  Gut       Date:  1992-03       Impact factor: 23.059

8.  Proteomic evidence of bacterial peptide translocation in afebrile patients with cirrhosis and ascites.

Authors:  Rocío Caño; Lucía Llanos; Pedro Zapater; Sonia Pascual; Pablo Bellot; Claudia Barquero; Miguel Pérez-Mateo; José Such; Rubén Francés
Journal:  J Mol Med (Berl)       Date:  2010-01-20       Impact factor: 4.599

9.  Bacterial DNA activates cell mediated immune response and nitric oxide overproduction in peritoneal macrophages from patients with cirrhosis and ascites.

Authors:  R Francés; C Muñoz; P Zapater; F Uceda; I Gascón; S Pascual; M Pérez-Mateo; J Such
Journal:  Gut       Date:  2004-06       Impact factor: 23.059

10.  Association between proton pump inhibitor use and spontaneous bacterial peritonitis in cirrhotic patients with ascites.

Authors:  Melissa Ratelle; Sylvie Perreault; Jean-Pierre Villeneuve; Lydjie Tremblay
Journal:  Can J Gastroenterol Hepatol       Date:  2014-06
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