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Literature DB >> 32790432

Photophysical Tuning of Shortwave Infrared Flavylium Heptamethine Dyes via Substituent Placement.

Monica Pengshung¹, Jingbai Li², Fatemah Mukadum², Steven A Lopez², Ellen M Sletten¹.

Abstract

Optical imaging in the shortwave infrared region (SWIR, 1000-2000 nm) provides high-resolution images in complex systems. Here we explore substituent placement on dimethylamino flavylium polymethine dyes, a class of SWIR fluorophores. We find that the position of the substituent significantly affects the λmax and fluorescence quantum yield. Quantum-mechanical calculations suggest that steric clashes control the extent of π-conjugation. These insights provide design principles for the development of fluorophores for enhanced SWIR imaging.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Fluorescent Dyes

Year: 2020 PMID： 32790432 PMCID： PMC7542986 DOI： 10.1021/acs.orglett.0c02213

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

24 in total

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Journal: Proc Natl Acad Sci U S A Date: 2018-04-06 Impact factor: 11.205

Photophysical Tuning of Shortwave Infrared Flavylium Heptamethine Dyes via Substituent Placement.

1. A clearer vision for in vivo imaging.

2. In vivo fluorescence imaging in the second near-infrared window with long circulating carbon nanotubes capable of ultrahigh tumor uptake.

3. Continuous surface charge polarizable continuum models of solvation. I. General formalism.

Review 4. Bright ideas for chemical biology.

5. Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green.

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