Literature DB >> 32789777

Estimating Brain Permeability Using In Vitro Blood-Brain Barrier Models.

Saeideh Nozohouri1,2, Behnam Noorani1,2, Abraham Al-Ahmad1,2, Thomas J Abbruscato3,4.   

Abstract

The blood-brain barrier (BBB) is a vital biological interface that regulates transfer of different molecules between blood and brain and, therefore, maintains the homeostatic environment of the CNS. In order to perform high-throughput screening of therapeutics in drug discovery, specific properties of the BBB are investigated within in vitro BBB platforms. In this chapter, we detail the process and steps for the iPSC to BMEC and astrocyte differentiation as well as TEER and permeability measurement in Transwell platform of in vitro BBB model. Also, advanced microfluidic iPSCs-derived BMECs on chip and permeability measurement within this model have been elucidated.

Entities:  

Keywords:  Astrocytes; BBB; Co-culture model; Endothelial cells; In vitro permeability; Microfluidic chips; Transwell insert; iPSC

Mesh：

Year:  2021        PMID： 32789777     DOI： 10.1007/7651_2020_311

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  58 in total

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Journal:  Pharmacol Rev       Date:  2005-06       Impact factor: 25.468

Review 2.  Blood-brain barrier delivery.

Authors:  William M Pardridge
Journal:  Drug Discov Today       Date:  2006-11-13       Impact factor: 7.851

Review 3.  Modelling of the blood-brain barrier in drug discovery and development.

Authors:  Romeo Cecchelli; Vincent Berezowski; Stefan Lundquist; Maxime Culot; Mila Renftel; Marie-Pierre Dehouck; Laurence Fenart
Journal:  Nat Rev Drug Discov       Date:  2007-08       Impact factor: 84.694

Review 4.  Structure and function of the blood-brain barrier.

Authors:  N Joan Abbott; Adjanie A K Patabendige; Diana E M Dolman; Siti R Yusof; David J Begley
Journal:  Neurobiol Dis       Date:  2009-08-05       Impact factor: 5.996

Review 5.  In Vitro Blood-Brain Barrier Models-An Overview of Established Models and New Microfluidic Approaches.

Authors:  Anette Wolff; Maria Antfolk; Birger Brodin; Maria Tenje
Journal:  J Pharm Sci       Date:  2015-01-28       Impact factor: 3.534

Review 6.  In vitro models of the blood-brain barrier for the study of drug delivery to the brain.

Authors:  Imola Wilhelm; István A Krizbai
Journal:  Mol Pharm       Date:  2014-04-18       Impact factor: 4.939

7.  Pericytes are required for blood-brain barrier integrity during embryogenesis.

Authors:  Richard Daneman; Lu Zhou; Amanuel A Kebede; Ben A Barres
Journal:  Nature       Date:  2010-10-13       Impact factor: 49.962

Review 8.  Novel approaches for the delivery of therapeutics in ischemic stroke.

Authors:  Saeideh Nozohouri; Ali Ehsan Sifat; Bhuvaneshwar Vaidya; Thomas J Abbruscato
Journal:  Drug Discov Today       Date:  2020-01-21       Impact factor: 7.851

9.  Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010.

Authors:  Rafael Lozano; Mohsen Naghavi; Kyle Foreman; Stephen Lim; Kenji Shibuya; Victor Aboyans; Jerry Abraham; Timothy Adair; Rakesh Aggarwal; Stephanie Y Ahn; Miriam Alvarado; H Ross Anderson; Laurie M Anderson; Kathryn G Andrews; Charles Atkinson; Larry M Baddour; Suzanne Barker-Collo; David H Bartels; Michelle L Bell; Emelia J Benjamin; Derrick Bennett; Kavi Bhalla; Boris Bikbov; Aref Bin Abdulhak; Gretchen Birbeck; Fiona Blyth; Ian Bolliger; Soufiane Boufous; Chiara Bucello; Michael Burch; Peter Burney; Jonathan Carapetis; Honglei Chen; David Chou; Sumeet S Chugh; Luc E Coffeng; Steven D Colan; Samantha Colquhoun; K Ellicott Colson; John Condon; Myles D Connor; Leslie T Cooper; Matthew Corriere; Monica Cortinovis; Karen Courville de Vaccaro; William Couser; Benjamin C Cowie; Michael H Criqui; Marita Cross; Kaustubh C Dabhadkar; Nabila Dahodwala; Diego De Leo; Louisa Degenhardt; Allyne Delossantos; Julie Denenberg; Don C Des Jarlais; Samath D Dharmaratne; E Ray Dorsey; Tim Driscoll; Herbert Duber; Beth Ebel; Patricia J Erwin; Patricia Espindola; Majid Ezzati; Valery Feigin; Abraham D Flaxman; Mohammad H Forouzanfar; Francis Gerry R Fowkes; Richard Franklin; Marlene Fransen; Michael K Freeman; Sherine E Gabriel; Emmanuela Gakidou; Flavio Gaspari; Richard F Gillum; Diego Gonzalez-Medina; Yara A Halasa; Diana Haring; James E Harrison; Rasmus Havmoeller; Roderick J Hay; Bruno Hoen; Peter J Hotez; Damian Hoy; Kathryn H Jacobsen; Spencer L James; Rashmi Jasrasaria; Sudha Jayaraman; Nicole Johns; Ganesan Karthikeyan; Nicholas Kassebaum; Andre Keren; Jon-Paul Khoo; Lisa Marie Knowlton; Olive Kobusingye; Adofo Koranteng; Rita Krishnamurthi; Michael Lipnick; Steven E Lipshultz; Summer Lockett Ohno; Jacqueline Mabweijano; Michael F MacIntyre; Leslie Mallinger; Lyn March; Guy B Marks; Robin Marks; Akira Matsumori; Richard Matzopoulos; Bongani M Mayosi; John H McAnulty; Mary M McDermott; John McGrath; George A Mensah; Tony R Merriman; Catherine Michaud; Matthew Miller; Ted R Miller; Charles Mock; Ana Olga Mocumbi; Ali A Mokdad; Andrew Moran; Kim Mulholland; M Nathan Nair; Luigi Naldi; K M Venkat Narayan; Kiumarss Nasseri; Paul Norman; Martin O'Donnell; Saad B Omer; Katrina Ortblad; Richard Osborne; Doruk Ozgediz; Bishnu Pahari; Jeyaraj Durai Pandian; Andrea Panozo Rivero; Rogelio Perez Padilla; Fernando Perez-Ruiz; Norberto Perico; David Phillips; Kelsey Pierce; C Arden Pope; Esteban Porrini; Farshad Pourmalek; Murugesan Raju; Dharani Ranganathan; Jürgen T Rehm; David B Rein; Guiseppe Remuzzi; Frederick P Rivara; Thomas Roberts; Felipe Rodriguez De León; Lisa C Rosenfeld; Lesley Rushton; Ralph L Sacco; Joshua A Salomon; Uchechukwu Sampson; Ella Sanman; David C Schwebel; Maria Segui-Gomez; Donald S Shepard; David Singh; Jessica Singleton; Karen Sliwa; Emma Smith; Andrew Steer; Jennifer A Taylor; Bernadette Thomas; Imad M Tleyjeh; Jeffrey A Towbin; Thomas Truelsen; Eduardo A Undurraga; N Venketasubramanian; Lakshmi Vijayakumar; Theo Vos; Gregory R Wagner; Mengru Wang; Wenzhi Wang; Kerrianne Watt; Martin A Weinstock; Robert Weintraub; James D Wilkinson; Anthony D Woolf; Sarah Wulf; Pon-Hsiu Yeh; Paul Yip; Azadeh Zabetian; Zhi-Jie Zheng; Alan D Lopez; Christopher J L Murray; Mohammad A AlMazroa; Ziad A Memish
Journal:  Lancet       Date:  2012-12-15       Impact factor: 79.321

Review 10.  Markers for blood-brain barrier integrity: how appropriate is Evans blue in the twenty-first century and what are the alternatives?

Authors:  Norman R Saunders; Katarzyna M Dziegielewska; Kjeld Møllgård; Mark D Habgood
Journal:  Front Neurosci       Date:  2015-10-29       Impact factor: 4.677
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Review 1.  Organ-On-A-Chip Models of the Blood-Brain Barrier: Recent Advances and Future Prospects.

Authors:  Satoru Kawakita; Kalpana Mandal; Lei Mou; Marvin Magan Mecwan; Yangzhi Zhu; Shaopei Li; Saurabh Sharma; Ana Lopez Hernandez; Huu Tuan Nguyen; Surjendu Maity; Natan Roberto de Barros; Aya Nakayama; Praveen Bandaru; Samad Ahadian; Han-Jun Kim; Rondinelli Donizetti Herculano; Eggehard Holler; Vadim Jucaud; Mehmet Remzi Dokmeci; Ali Khademhosseini
Journal:  Small       Date:  2022-08-17       Impact factor: 15.153

2.  Discovery of First-in-Class Peptidomimetic Neurolysin Activators Possessing Enhanced Brain Penetration and Stability.

Authors:  Md Shafikur Rahman; Shikha Kumari; Shiva Hadi Esfahani; Saeideh Nozohouri; Srinidhi Jayaraman; Nihar Kinarivala; Joanna Kocot; Andrew Baez; Delaney Farris; Thomas J Abbruscato; Vardan T Karamyan; Paul C Trippier
Journal:  J Med Chem       Date:  2021-08-26       Impact factor: 8.039

3.  Comparative studies between the murine immortalized brain endothelial cell line (bEnd.3) and induced pluripotent stem cell-derived human brain endothelial cells for paracellular transport.

Authors:  Jiahong Sun; Weijun Ou; Derick Han; Annlia Paganini-Hill; Mark J Fisher; Rachita K Sumbria
Journal:  PLoS One       Date:  2022-05-25       Impact factor: 3.752

Review 4.  Repurposing metformin to treat age-related neurodegenerative disorders and ischemic stroke.

Authors:  Sejal Sharma; Saeideh Nozohouri; Bhuvaneshwar Vaidya; Thomas Abbruscato
Journal:  Life Sci       Date:  2021-03-11       Impact factor: 6.780

5.  Comparative assessment of in vitro BBB tight junction integrity following exposure to cigarette smoke and e-cigarette vapor: a quantitative evaluation of the protective effects of metformin using small-molecular-weight paracellular markers.

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Journal:  Fluids Barriers CNS       Date:  2021-06-22
  5 in total

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