Literature DB >> 32787587

The tumor microenvironment of colorectal cancer metastases: opportunities in cancer immunotherapy.

Yasmin Kamal1,2, Stephanie L Schmit3, Hildreth Robert Frost1,2, Christopher I Amos1,2,4.   

Abstract

About a fifth of individuals with colorectal cancer (CRC) present with disease metastasis at the time of diagnosis. While the role of the tumor microenvironment (TME) in governing CRC progression is undeniable, the role of the TME in either establishing or suppressing the formation of distant metastases of CRC is less well established. Despite advances in immunotherapy, many individuals with metastatic CRC do not respond to standard-of-care therapy. Therefore, understanding the role of the TME in establishing distant metastases is essential for developing new immunological agents. Here, we summarize our current understanding of the TME of CRC metastases, describe differences between the TME of primary tumors and their distant metastases, and discuss advances in the design and combinations of immunotherapeutic agents.

Entities:  

Keywords:  CAR-T-cell therapy; Toll-like receptor agonists; bi-specific T-cell engagers; colorectal cancer; dendritic cell vaccine; immune checkpoint inhibitors; immune microenvironment; liver metastases; metastasis; microsatellite instability

Year:  2020        PMID： 32787587     DOI： 10.2217/imt-2020-0026

Source DB:  PubMed          Journal:  Immunotherapy        ISSN： 1750-743X            Impact factor:   4.196


  10 in total

1.  HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer.

Authors:  Guangying Xu; Liling Niu; Youhui Wang; Guang Yang; Xingwu Zhu; Yuan Yao; Gang Zhao; Shaowei Wang; Hui Li
Journal:  Cell Death Dis       Date:  2022-10-21       Impact factor: 9.685

2.  Revisiting social MPE: an integration of molecular pathological epidemiology and social science in the new era of precision medicine.

Authors:  Jin Dai; Akihiro Nishi; Nathan Tran; Yasumasa Yamamoto; George Dewey; Tomotaka Ugai; Shuji Ogino
Journal:  Expert Rev Mol Diagn       Date:  2021-07-26       Impact factor: 5.670

3.  Immune cell profiles in the tumor microenvironment of early-onset, intermediate-onset, and later-onset colorectal cancer.

Authors:  Tomotaka Ugai; Jennifer Borowsky; Marios Giannakis; Shuji Ogino; Juha P Väyrynen; Mai Chan Lau; Naohiko Akimoto; Sara A Väyrynen; Melissa Zhao; Rong Zhong; Koichiro Haruki; Andressa Dias Costa; Kenji Fujiyoshi; Kota Arima; Kana Wu; Andrew T Chan; Yin Cao; Mingyang Song; Charles S Fuchs; Molin Wang; Jochen K Lennerz; Kimmie Ng; Jeffrey A Meyerhardt; Jonathan A Nowak
Journal:  Cancer Immunol Immunother       Date:  2021-09-16       Impact factor: 6.630

4.  Association of Fusobacterium nucleatum with Specific T-cell Subsets in the Colorectal Carcinoma Microenvironment.

Authors:  Jennifer Borowsky; Koichiro Haruki; Mai Chan Lau; Andressa Dias Costa; Jochen K Lennerz; Marios Giannakis; Jonathan A Nowak; Shuji Ogino; Juha P Väyrynen; Tomotaka Ugai; Kota Arima; Annacarolina da Silva; Kristen D Felt; Melissa Zhao; Carino Gurjao; Tyler S Twombly; Kenji Fujiyoshi; Sara A Väyrynen; Tsuyoshi Hamada; Kosuke Mima; Susan Bullman; Tabitha A Harrison; Amanda I Phipps; Ulrike Peters; Kimmie Ng; Jeffrey A Meyerhardt; Mingyang Song; Edward L Giovannucci; Kana Wu; Xuehong Zhang; Gordon J Freeman; Curtis Huttenhower; Wendy S Garrett; Andrew T Chan; Barbara A Leggett; Vicki L J Whitehall; Neal Walker; Ian Brown; Mark Bettington; Reiko Nishihara; Charles S Fuchs
Journal:  Clin Cancer Res       Date:  2021-02-25       Impact factor: 13.801

5.  Significance of Kynurenine 3-Monooxygenase Expression in Colorectal Cancer.

Authors:  Chun-Yu Liu; Tzu-Ting Huang; Ji-Lin Chen; Pei-Yi Chu; Chia-Han Lee; Hsin-Chen Lee; Yu-Hsuan Lee; Yuan-Ya Chang; Shung-Haur Yang; Jeng-Kai Jiang; Wei-Shone Chen; Yee Chao; Hao-Wei Teng
Journal:  Front Oncol       Date:  2021-04-16       Impact factor: 6.244

6.  Identifying Potential Biomarkers of Prognostic Value in Colorectal Cancer via Tumor Microenvironment Data Mining.

Authors:  Lei Li; Xiao Du; Guangyi Fan
Journal:  Front Genet       Date:  2022-02-03       Impact factor: 4.599

Review 7.  Molecular Mechanisms of Tumor Immunomodulation in the Microenvironment of Colorectal Cancer.

Authors:  Dorothea Plundrich; Sophia Chikhladze; Stefan Fichtner-Feigl; Reinhild Feuerstein; Priscilla S Briquez
Journal:  Int J Mol Sci       Date:  2022-03-03       Impact factor: 5.923

Review 8.  Tumor microenvironment involvement in colorectal cancer progression via Wnt/β-catenin pathway: Providing understanding of the complex mechanisms of chemoresistance.

Authors:  María Belén Novoa Díaz; María Julia Martín; Claudia Gentili
Journal:  World J Gastroenterol       Date:  2022-07-14       Impact factor: 5.374

Review 9.  The Therapeutic Potential of Tackling Tumor-Induced Dendritic Cell Dysfunction in Colorectal Cancer.

Authors:  Beatriz Subtil; Alessandra Cambi; Daniele V F Tauriello; I Jolanda M de Vries
Journal:  Front Immunol       Date:  2021-10-06       Impact factor: 7.561

10.  Immunohistochemical analysis of PD-L1 and tumor-infiltrating immune cells expression in the tumor microenvironment of primary signet ring cell carcinoma of the prostate.

Authors:  Qi-Liang Teng; Xin-Rui Yang; Shuang Wen; Zhi-Hong Dai; Hong-Long Wang; Tian-Qing Liu; Liang Wang; Bo Fan; Zhi-Yu Liu
Journal:  Asian J Androl       Date:  2022 Sep-Oct       Impact factor: 3.054
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.