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Literature DB >> 3278695

Synovial fluid neutrophils of patients with rheumatoid arthritis have membrane antigen changes that reflect activation.

P Emery¹, A F Lopez, G F Burns, M A Vadas.

Abstract

The level of expression of surface antigens was studied on neutrophils from paired samples of blood and synovial fluid of patients with rheumatoid arthritis (RA). By measuring the immunofluorescence of labelled monoclonal antibodies it was shown that on joint neutrophils there was an increase in expression of complement receptor 3 (CR3) and granulocyte functional antigens 1 and 2 compared with blood neutrophils, whereas the expression of GpIIb-IIIa was reduced. The pattern of expression was the same as that seen with in vitro activation and strongly suggest that activation is occurring within the joint.

Entities: Disease Species

Mesh：

Substances：

Year: 1988 PMID： 3278695 PMCID： PMC1003440 DOI： 10.1136/ard.47.1.34

Source DB: PubMed Journal: Ann Rheum Dis ISSN： 0003-4967 Impact factor: 19.103

17 in total

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16 in total

1. Neutrophils from the synovial fluid of patients with rheumatoid arthritis express the high affinity immunoglobulin G receptor, Fc gamma RI (CD64): role of immune complexes and cytokines in induction of receptor expression.

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Journal: Immunology Date: 1997-06 Impact factor: 7.397

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