CF Distance: A New Domain Discrepancy Metric and Application to Explicit Domain Adaptation for Cross-Modality Cardiac Image Segmentation.

Domain adaptation has great values in unpaired cross-modality image segmentation, where the training images with gold standard segmentation are not available from the target image domain. The aim is to reduce the distribution discrepancy between the source and target domains. Hence, an effective measurement for this discrepancy is critical. In this work, we propose a new metric based on characteristic functions of distributions. This metric, referred to as CF distance, enables explicit domain adaptation, in contrast to the implicit manners minimizing domain discrepancy via adversarial training. Based on this CF distance, we propose an unsupervised domain adaptation framework for cross-modality cardiac segmentation, which consists of image reconstruction and prior distribution matching. We validated the method on two tasks, i.e., the CT-MR cross-modality segmentation and the multi-sequence cardiac MR segmentation. Results showed that the proposed explicit metric was effective in domain adaptation, and the segmentation method delivered promising and superior performance, compared to other state-of-the-art techniques. The data and source code of this work has been released via https://zmiclab.github.io/projects.html.