| Literature DB >> 32783700 |
Mohamad Hesam Shahrajabian1, Wenli Sun1, Qi Cheng1,2,3.
Abstract
SARS-CoV-2, the virus causing COVID-19, is a single-stranded RNA virus belonging to the order Nidovirales, family Coronaviridae, and subfamily Coronavirinae. SARS-CoV-2 entry to cellsis initiated by the binding of the viral spike protein (S) to its cellular receptor. The roles of S protein in receptor binding and membrane fusion makes it a prominent target for vaccine development. SARS-CoV-2 genome sequence analysis has shown that this virus belongs to the beta-coronavirus genus, which includes Bat SARS-like coronavirus, SARS-CoV and MERS-CoV. A vaccine should induce a balanced immune response to elicit protective immunity. In this review, we compare and contrast these three important CoV diseases and how they inform on vaccine development.Entities:
Keywords: MERS; SARS; SARS-CoV-2; coronaviruses; emerging diseases; pneumonia
Mesh:
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Year: 2020 PMID: 32783700 PMCID: PMC7872062 DOI: 10.1080/21645515.2020.1797369
Source DB: PubMed Journal: Hum Vaccin Immunother ISSN: 2164-5515 Impact factor: 3.452