Literature DB >> 32783608

The SLC25 Carrier Family: Important Transport Proteins in Mitochondrial Physiology and Pathology.

Edmund R S Kunji1, Martin S King1, Jonathan J Ruprecht1, Chancievan Thangaratnarajah2.   

Abstract

Members of the mitochondrial carrier family (SLC25) transport a variety of compounds across the inner membrane of mitochondria. These transport steps provide building blocks for the cell and link the pathways of the mitochondrial matrix and cytosol. An increasing number of diseases and pathologies has been associated with their dysfunction. In this review, the molecular basis of these diseases is explained based on our current understanding of their transport mechanism.

Entities:  

Keywords:  bioenergetics; impaired transport mechanism; mitochondrial disease; mitochondrial physiology; pathological mutations

Mesh：

Substances：

Year:  2020        PMID： 32783608     DOI： 10.1152/physiol.00009.2020

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  20 in total

1.  Structure, substrate binding, and symmetry of the mitochondrial ADP/ATP carrier in its matrix-open state.

Authors:  Joel José Montalvo-Acosta; Edmund R S Kunji; Jonathan J Ruprecht; François Dehez; Christophe Chipot
Journal:  Biophys J       Date:  2021-11-06       Impact factor: 4.033

2.  Dysregulated Gene Expression in Lymphoblasts from Parkinson's Disease.

Authors:  Sarah Jane Annesley; Claire Yvonne Allan; Oana Sanislav; Andrew Evans; Paul Robert Fisher
Journal:  Proteomes       Date:  2022-06-01

3.  Substrate binding in the mitochondrial ADP/ATP carrier is a step-wise process guiding the structural changes in the transport cycle.

Authors:  Vasiliki Mavridou; Martin S King; Sotiria Tavoulari; Jonathan J Ruprecht; Shane M Palmer; Edmund R S Kunji
Journal:  Nat Commun       Date:  2022-06-23       Impact factor: 17.694

Review 4.  Structural and functional comparison of magnesium transporters throughout evolution.

Authors:  G A C Franken; M A Huynen; L A Martínez-Cruz; R J M Bindels; J H F de Baaij
Journal:  Cell Mol Life Sci       Date:  2022-07-12       Impact factor: 9.207

5.  Pathogenic SLC25A26 variants impair SAH transport activity causing mitochondrial disease.

Authors:  Florian A Schober; Jia Xin Tang; Kate Sergeant; Marco F Moedas; Charlotte M Zierz; David Moore; Conrad Smith; David Lewis; Nishan Guha; Sila Hopton; Gavin Falkous; Amanda Lam; Angela Pyle; Joanna Poulton; Gráinne S Gorman; Robert W Taylor; Christoph Freyer; Anna Wredenberg
Journal:  Hum Mol Genet       Date:  2022-06-22       Impact factor: 5.121

Review 6.  The mitochondrial ADP/ATP carrier exists and functions as a monomer.

Authors:  Edmund R S Kunji; Jonathan J Ruprecht
Journal:  Biochem Soc Trans       Date:  2020-08-28       Impact factor: 5.407

Review 7.  The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond.

Authors:  Rami Mosaoa; Anna Kasprzyk-Pawelec; Harvey R Fernandez; Maria Laura Avantaggiati
Journal:  Biomolecules       Date:  2021-01-22

Review 8.  Amino Acid Transporters on the Guard of Cell Genome and Epigenome.

Authors:  Uğur Kahya; Ayşe Sedef Köseer; Anna Dubrovska
Journal:  Cancers (Basel)       Date:  2021-01-02       Impact factor: 6.639

Review 9.  SLC6A14 and SLC38A5 Drive the Glutaminolysis and Serine-Glycine-One-Carbon Pathways in Cancer.

Authors:  Tyler Sniegowski; Ksenija Korac; Yangzom D Bhutia; Vadivel Ganapathy
Journal:  Pharmaceuticals (Basel)       Date:  2021-03-04

10.  Physiology in Perspective: A Key Role of Physiology in Understanding COVID-19.

Authors:  Gary C Sieck
Journal:  Physiology (Bethesda)       Date:  2020-09-01
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