Jeremy Cheuk Kin Sin1,2, Lillian King1,2, Emma Ballard3, Stacey Llewellyn3, Kevin B Laupland4,5, Alexis Tabah1,2. 1. Intensive Care Unit, 60077Redcliffe Hospital, Redcliffe, Queensland, Australia. 2. Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia. 3. 56362QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. 4. 550021Department of Intensive Care Services, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia. 5. Queensland University of Technology, Brisbane, Queensland, Australia.
Abstract
PURPOSE: Hypophosphatemia is reported in up to 5% of hospitalized patients and ranges from 20% to 80% in critically ill patients. The consequences of hypophosphatemia for critically ill patients remain controversial. We evaluated the effect of hypophosphatemia on mortality and length of stay in intensive care unit (ICU) patients. METHODS: MEDLINE, EMBASE, Cochrane Library (Reviews and Trials), and PubMed were searched for articles in English. The primary outcome was mortality and secondary outcome was length of stay. The quality of evidence was graded using a modified Newcastle-Ottawa Scale. RESULTS: Our search yielded 828 articles and ultimately included 12 studies with 7626 participants in the analysis. Hypophosphatemia was associated with increased hospital length of stay (2.19 days [95% CI, 1.74-2.64]) and ICU length of stay (2.22 days [95% CI, 1.00-3.44]) but not mortality (risk ratio: 1.13 [95% CI, 0.98-1.31]; P = .09). CONCLUSIONS: Hypophosphatemia in ICU was associated with increased hospital and ICU length of stay but not all-cause mortality. Hypophosphatemia appears to be a marker of disease severity. Limited number of available studies and varied study designs did not allow for the ascertainment of the effect of severe hypophosphatemia on patient mortality.
PURPOSE: Hypophosphatemia is reported in up to 5% of hospitalized patients and ranges from 20% to 80% in critically ill patients. The consequences of hypophosphatemia for critically ill patients remain controversial. We evaluated the effect of hypophosphatemia on mortality and length of stay in intensive care unit (ICU) patients. METHODS: MEDLINE, EMBASE, Cochrane Library (Reviews and Trials), and PubMed were searched for articles in English. The primary outcome was mortality and secondary outcome was length of stay. The quality of evidence was graded using a modified Newcastle-Ottawa Scale. RESULTS: Our search yielded 828 articles and ultimately included 12 studies with 7626 participants in the analysis. Hypophosphatemia was associated with increased hospital length of stay (2.19 days [95% CI, 1.74-2.64]) and ICU length of stay (2.22 days [95% CI, 1.00-3.44]) but not mortality (risk ratio: 1.13 [95% CI, 0.98-1.31]; P = .09). CONCLUSIONS: Hypophosphatemia in ICU was associated with increased hospital and ICU length of stay but not all-cause mortality. Hypophosphatemia appears to be a marker of disease severity. Limited number of available studies and varied study designs did not allow for the ascertainment of the effect of severe hypophosphatemia on patient mortality.
Authors: Hannah Wozniak; André Dos Santos Rocha; Tal Sarah Beckmann; Christophe Larpin; Niccolò Buetti; Hervé Quintard; Jérôme Pugin; Claudia Paula Heidegger Journal: J Clin Med Date: 2022-01-24 Impact factor: 4.241
Authors: Shmeylan A Al Harbi; Hasan M Al-Dorzi; Albatool M Al Meshari; Hani Tamim; Sheryl Ann I Abdukahil; Musharaf Sadat; Yaseen Arabi Journal: BMC Pharmacol Toxicol Date: 2021-05-28 Impact factor: 2.483