Civil unrest erupted across the country in the aftermath of the murder of George Floyd. As Black Lives Matter peaceful protests against police brutality toward black Americans spread nationwide, looting and rioting escalated also. Similar to several large urban cities, Chicago was severely affected by these events. Extreme looting spread across the city and devastated already marginalized communities of color, especially in the South Side of Chicago. As lifelong residents of Chicago and Pharmacy Educators at the Chicago State University College of Pharmacy (CSU-COP) located on the South Side of Chicago, we root ourselves in educating and practicing pharmacy and community outreach in minority and underserved populations of this community.In recent years, the community surrounding CSU-COP has transformed into a pharmacy desert. A pharmacy desert is defined as a low-access community whose residents must travel farther to the nearest pharmacy to obtain their prescription medications. A community is designated as a pharmacy desert if it is considered low access and low income. On the basis of data from the Illinois Department of Financial and Professional Regulation, most South Side Chicago communities have fewer than 6 pharmacies per square mile, and there are widespread areas with fewer than 2 pharmacies per square mile. The health impact owing to the dearth of pharmacies and pharmacy services in segregated South Side black communities was exacerbated in the aftermath of the looting owing to the pharmacy closures. One major pharmacy retailer had 85 pharmacy locations within the city of Chicago damaged and temporarily closed owing to looting; 45 of these stores were located on the South Side of Chicago. Some stores continue to remain closed more than a month after closing, and it is uncertain whether they will reopen. Another major pharmacy retailer, Walmart, announced that it will reopen all 7 stores that were closed owing to looting by the end of 2020. Some of these stores were extensively damaged, and 1 was set on fire. The Walmart CEO stated that the company will continue to invest in these marginalized communities, which is important because these stores provide grocery and pharmacy services to areas of food insecurity and pharmacy deserts.The South Side of Chicago has a disproportionate amount of people with chronic conditions and deaths from coronavirus disease (COVID-19). There is also a disproportionate amount of segregation, systemic racism, and lower socioeconomic status, which exacerbates the lack of resources and needs for this community. Thousands of people were concerned when they could not get access to their local pharmacy. Patients, especially seniors, were uncertain as to how and when they would get their medicines. Many patients with limited or no transportation had to forgo their medicine because they had no access outside of their community. Fear among community residents is growing that some of the looted pharmacies will not reopen in the economically disadvantaged areas and pharmacy deserts where they are needed the most.Pharmacy closures from the looting severely affected the health care system already stressed from COVID-19. Pharmacists were displaced from their closed stores. The nearest open pharmacies were backlogged with prescription fills and transfers, overwhelmed with long lines that wrapped around inside the store and outside of the drive-through, and uncertain as to when medications would be available for pickup. Providers were unsure which pharmacies were open and where to send prescriptions. Some independent pharmacies were minimally damaged and able to fill in the gap in helping patients fill prescriptions that were unable to be filled at their regular large chain pharmacy.Recent societal events have shown that pharmacists and pharmacies are vital to the health and well-being of the communities in which they serve. In addition to providing medications and medical advice, local community pharmacies provide medical care through in-store clinics, increasing access to care and providing healthy food options and household goods in communities with limited resources. Their purpose and service do not go unnoticed—we volunteered to clean up looted black-owned independent pharmacies that have been in business for decades in this community. Pharmacists have persevered on the front lines through this unprecedented time with the COVID-19 pandemic and sudden, widespread closure of pharmacies amid the outcry of racial injustice. Pharmacists continue to remain one of the most trusted and accessible health professionals, and they are essential workers. Despite difficult and demanding work environments, pharmacists continue to provide exceptional pharmaceutical care to optimize clinical outcomes, and empathy and compassion to the patients they serve. Furthermore, we will continue to invest in our students, patients, and community on the South Side of Chicago.