| Literature DB >> 32781204 |
Yu Shangguan1, Chunhong Li1, Hua Lin2, Minglin Ou2, Donge Tang3, Yong Dai4, Qiang Yan5.
Abstract
Embryonic development is a complex process that is regulated by a series of precise cellular behaviours. The limited number of cells in the early stages of embryonic development represents a challenge for studying early gene regulation and maintaining cell sternness. Single-cell sequencing is a new technology for high-throughput sequencing analysis at the single-cell level that not only reflects the heterogeneity between cells but also reveals gene expression characteristics in different cells from limited samples. Currently, the widespread application of single-cell RNA sequencing technology is gradually changing our understanding of disease pathogenesis. This article reviews the application of single-cell RNA sequencing in embryonic development in recent years and provides innovative ideas for research on embryonic development and the treatment of diseases related to embryonic development.Keywords: Cellular heterogeneity; Embryonic development; Single-cell RNA sequencing
Year: 2020 PMID: 32781204 DOI: 10.1016/j.ygeno.2020.08.007
Source DB: PubMed Journal: Genomics ISSN: 0888-7543 Impact factor: 5.736