Literature DB >> 32781204

Application of single-cell RNA sequencing in embryonic development.

Yu Shangguan1, Chunhong Li1, Hua Lin2, Minglin Ou2, Donge Tang3, Yong Dai4, Qiang Yan5.   

Abstract

Embryonic development is a complex process that is regulated by a series of precise cellular behaviours. The limited number of cells in the early stages of embryonic development represents a challenge for studying early gene regulation and maintaining cell sternness. Single-cell sequencing is a new technology for high-throughput sequencing analysis at the single-cell level that not only reflects the heterogeneity between cells but also reveals gene expression characteristics in different cells from limited samples. Currently, the widespread application of single-cell RNA sequencing technology is gradually changing our understanding of disease pathogenesis. This article reviews the application of single-cell RNA sequencing in embryonic development in recent years and provides innovative ideas for research on embryonic development and the treatment of diseases related to embryonic development.
Copyright © 2020 Elsevier Inc. All rights reserved.

Keywords:  Cellular heterogeneity; Embryonic development; Single-cell RNA sequencing

Year:  2020        PMID: 32781204     DOI: 10.1016/j.ygeno.2020.08.007

Source DB:  PubMed          Journal:  Genomics        ISSN: 0888-7543            Impact factor:   5.736


  1 in total

Review 1.  Sample-multiplexing approaches for single-cell sequencing.

Authors:  Yulong Zhang; Siwen Xu; Zebin Wen; Jinyu Gao; Shuang Li; Sherman M Weissman; Xinghua Pan
Journal:  Cell Mol Life Sci       Date:  2022-08-05       Impact factor: 9.207

  1 in total

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