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Literature DB >> 32780848

Cell interactions in the bone marrow microenvironment affecting myeloid malignancies.

Konstantinos D Kokkaliaris^1,2,3, David T Scadden^1,2,3.

Abstract

The bone marrow is a complex tissue in which heterogeneous populations of stromal cells interact with hematopoietic cells to dynamically respond to organismal needs in defense, hemostasis, and oxygen delivery. Physiologic challenges modify stromal/hematopoietic cell interactions to generate changes in blood cell production. When either stroma or hematopoietic cells are impaired, the system distorts. The distortions associated with myeloid malignancy are reviewed here and may provide opportunities for therapeutic intervention.

Entities: Chemical Disease

Mesh：

Year: 2020 PMID： 32780848 PMCID： PMC7422101 DOI： 10.1182/bloodadvances.2020002127

Source DB: PubMed Journal: Blood Adv ISSN： 2473-9529

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