Zhiqiao Liang1, Yuou Yao1, Guosheng Sun1, Mingwei Zhao1, Hong Yin2. 1. Department of Ophthalmology, Peking University People's Hospital, Eye Diseases and Optometry Institute, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science Center, Beijng, China. 2. Department of Ophthalmology, Peking University People's Hospital, Eye Diseases and Optometry Institute, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science Center, Beijng, China. dr_yinhong@163.com.
Abstract
PURPOSE: The purpose of this retrospective case-control study was to evaluate the relationship between foveal structure, function, microvascular morphology and visual acuity in school-age children with laser-treated retinopathy of prematurity (ROP). METHODS: Foveal structural parameters, including the central foveal thickness (CFT), inner retinal thickness (IRT) and outer retinal thickness (ORT), were measured on B-scans using an Optovue XR Avanti optical coherence tomography device. Foveal microvascular parameters, including the foveal avascular zone (FAZ), superficial capillary plexus-vessel density (SCP-VD) and deep capillary plexus-vessel density (DCP-VD), were measured on optical coherence tomography angiography with a scan size of 3 × 3. The P1 amplitudes and P1 implicit times were recorded by a multifocal electroretinogram with 61 elements. RESULTS: Fifty-five eyes (26 eyes of school-age ROP children and 29 eyes of full-term controls) were analysed. The ROP children manifested a significantly smaller FAZ, higher SCP-VD and higher DCP-VD than the controls (p < 0.001). The CFT (p < 0.001), IRT (p < 0.001) and ORT (p = 0.001) were significantly increased in the ROP group. The P1 amplitudes in all five-ring retinal regions were significantly smaller in the ROP group (p < 0.001). Multivariable analysis indicated that best-corrected visual acuity was positively correlated with post-menstrual age (PMA) and negatively correlated with SCP-VD and CFT (R2 = 0.529, p < 0.001, 0.043 and 0.020, respectively). CONCLUSION: The foveal structure, function and microvascular morphology are affected in school-age children with laser-treated ROP. PMA, foveal structural anomalies and microvascular changes in ROP children were associated with impaired visual function.
PURPOSE: The purpose of this retrospective case-control study was to evaluate the relationship between foveal structure, function, microvascular morphology and visual acuity in school-age children with laser-treated retinopathy of prematurity (ROP). METHODS: Foveal structural parameters, including the central foveal thickness (CFT), inner retinal thickness (IRT) and outer retinal thickness (ORT), were measured on B-scans using an Optovue XR Avanti optical coherence tomography device. Foveal microvascular parameters, including the foveal avascular zone (FAZ), superficial capillary plexus-vessel density (SCP-VD) and deep capillary plexus-vessel density (DCP-VD), were measured on optical coherence tomography angiography with a scan size of 3 × 3. The P1 amplitudes and P1 implicit times were recorded by a multifocal electroretinogram with 61 elements. RESULTS: Fifty-five eyes (26 eyes of school-age ROP children and 29 eyes of full-term controls) were analysed. The ROP children manifested a significantly smaller FAZ, higher SCP-VD and higher DCP-VD than the controls (p < 0.001). The CFT (p < 0.001), IRT (p < 0.001) and ORT (p = 0.001) were significantly increased in the ROP group. The P1 amplitudes in all five-ring retinal regions were significantly smaller in the ROP group (p < 0.001). Multivariable analysis indicated that best-corrected visual acuity was positively correlated with post-menstrual age (PMA) and negatively correlated with SCP-VD and CFT (R2 = 0.529, p < 0.001, 0.043 and 0.020, respectively). CONCLUSION: The foveal structure, function and microvascular morphology are affected in school-age children with laser-treated ROP. PMA, foveal structural anomalies and microvascular changes in ROP children were associated with impaired visual function.