Zuo Zhang1, Lauren Robinson2, Tianye Jia3, Erin Burke Quinlan1, Nicole Tay1, Congying Chu1, Edward D Barker4, Tobias Banaschewski5, Gareth J Barker6, Arun L W Bokde7, Herta Flor8, Antoine Grigis9, Hugh Garavan10, Penny Gowland11, Andreas Heinz12, Bernd Ittermann13, Jean-Luc Martinot14, Argyris Stringaris15, Jani Penttilä16, Betteke van Noort17, Yvonne Grimmer5, Marie-Laure Paillère Martinot18, Corinna Isensee19, Andreas Becker19, Frauke Nees20, Dimitri Papadopoulos Orfanos9, Tomáš Paus21, Luise Poustka19, Sarah Hohmann5, Juliane H Fröhner22, Michael N Smolka22, Henrik Walter12, Robert Whelan23, Gunter Schumann24, Ulrike Schmidt25, Sylvane Desrivières26. 1. Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom. 2. Section of Eating Disorders, Department of Psychological Medicine, London, United Kingdom. 3. Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China; Ministry of Education-Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Shanghai, China. 4. Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom; Developmental Psychopathology Lab, Department of Psychology, King's College London, London, United Kingdom. 5. Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. 6. Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom. 7. Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland. 8. Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany. 9. NeuroSpin, Commissariat à l'Énergie Atomique, Université Paris-Saclay, Gif-sur-Yvette, France. 10. Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA. 11. Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom. 12. Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Charite Mitte, Berlin, Germany. 13. Physikalisch-Technische Bundesanstalt, Braunschweig and Berlin, Germany. 14. Institut National de la Santé et de la Recherche Médicale U A10 "Developmental Trajectories and Psychiatry", Université Paris-Saclay, École Normale Supérieure Paris-Saclay, Centre National de la Recherche Scientifique, Centre Borelli, Gif-sur-Yvette, France. 15. National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA. 16. Department of Social and Health Care, Psychosocial Services Adolescent Outpatient Clinic, Kauppakatu, Lahti, Finland. 17. Medical School Berlin, Berlin, Germany. 18. Institut National de la Santé et de la Recherche Médicale Unit 1000 "Neuroimaging & Psychiatry", Université Paris-Saclay, Université Paris Descartes, Sorbonne Université, Paris, France; Department of Child and Adolescent Psychiatry, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France. 19. Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany. 20. Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany. 21. Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada; Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, Canada. 22. Department of Psychiatry and Neuroimaging Center, Technische Universitat Dresden, Dresden, Germany. 23. School of Psychology and Global Brain Health Institute, Trinity College, Dublin, Ireland. 24. Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Charite Mitte, Berlin, Germany. 25. Section of Eating Disorders, Department of Psychological Medicine, London, United Kingdom; The Eating Disorders Service, Maudsley Hospital, South London, and Maudsley NHS Foundation Trust, London, United Kingdom. 26. Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom. Electronic address: sylvane.desrivieres@kcl.ac.uk.
Abstract
BACKGROUND: Eating disorders are common in adolescence and are devastating and strongly comorbid with other psychiatric disorders. Yet little is known about their etiology, knowing which would aid in developing effective preventive measures. METHODS: Longitudinal assessments of disordered eating behaviors (DEBs)-binge-eating, purging, and dieting-and comorbid psychopathology were measured in 1386 adolescents from the IMAGEN study. Development of DEBs and associated mental health problems was investigated by comparing participants who reported symptoms at ages 16 or 19 years, but not at age 14 years, with asymptomatic control participants. Voxel-based morphometry and psychopathological differences at age 14 were investigated to identify risk factors for the development of DEBs and associated mental health problems. RESULTS: DEBs and depressive symptoms developed together. Emotional and behavioral problems, including symptoms of attention-deficit/hyperactivity disorder and conduct disorder, predated their development. Alterations in frontostriatal brain areas also predated the development of DEBs and depressive symptoms. Specifically, development of binge-eating was predicted by higher gray matter volumes in the right putamen/globus pallidus at age 14. Conversely, development of purging and depressive symptoms was predicted by lower volumes in the medial orbitofrontal, dorsomedial, and dorsolateral prefrontal cortices. Lower gray matter volumes in the orbitofrontal and anterior cingulate cortices mediated the relationship between attention-deficit/hyperactivity disorder and conduct disorder symptoms and future purging and depressive symptoms. CONCLUSIONS: These findings suggest that alterations in frontal brain circuits are part of the shared etiology among eating disorders, attention-deficit/hyperactivity disorder, conduct disorder, and depression and highlight the importance of a transdiagnostic approach to treating these conditions.
BACKGROUND: Eating disorders are common in adolescence and are devastating and strongly comorbid with other psychiatric disorders. Yet little is known about their etiology, knowing which would aid in developing effective preventive measures. METHODS: Longitudinal assessments of disordered eating behaviors (DEBs)-binge-eating, purging, and dieting-and comorbid psychopathology were measured in 1386 adolescents from the IMAGEN study. Development of DEBs and associated mental health problems was investigated by comparing participants who reported symptoms at ages 16 or 19 years, but not at age 14 years, with asymptomatic control participants. Voxel-based morphometry and psychopathological differences at age 14 were investigated to identify risk factors for the development of DEBs and associated mental health problems. RESULTS: DEBs and depressive symptoms developed together. Emotional and behavioral problems, including symptoms of attention-deficit/hyperactivity disorder and conduct disorder, predated their development. Alterations in frontostriatal brain areas also predated the development of DEBs and depressive symptoms. Specifically, development of binge-eating was predicted by higher gray matter volumes in the right putamen/globus pallidus at age 14. Conversely, development of purging and depressive symptoms was predicted by lower volumes in the medial orbitofrontal, dorsomedial, and dorsolateral prefrontal cortices. Lower gray matter volumes in the orbitofrontal and anterior cingulate cortices mediated the relationship between attention-deficit/hyperactivity disorder and conduct disorder symptoms and future purging and depressive symptoms. CONCLUSIONS: These findings suggest that alterations in frontal brain circuits are part of the shared etiology among eating disorders, attention-deficit/hyperactivity disorder, conduct disorder, and depression and highlight the importance of a transdiagnostic approach to treating these conditions.
Authors: Lilian Calderón-Garcidueñas; Jacqueline Hernández-Luna; Partha S Mukherjee; Martin Styner; Diana A Chávez-Franco; Samuel C Luévano-Castro; Celia Nohemí Crespo-Cortés; Elijah W Stommel; Ricardo Torres-Jardón Journal: Toxics Date: 2022-03-25
Authors: Sarah El Archi; Samuele Cortese; Nicolas Ballon; Christian Réveillère; Arnaud De Luca; Servane Barrault; Paul Brunault Journal: Nutrients Date: 2020-10-27 Impact factor: 5.717
Authors: Jorem Emmillian Awadu; Alla Sikorskii; Sarah Zalwango; Audrey Coventry; Bruno Giordani; Amara E Ezeamama Journal: Int J Environ Res Public Health Date: 2022-03-21 Impact factor: 3.390