Literature DB >> 3277585

Red blood cell deformability in human and experimental sepsis.

T C Hurd1, K S Dasmahapatra, B F Rush, G W Machiedo.   

Abstract

Red blood cell (RBC) "deformability" is necessary for maintenance of normal microcirculation. To determine whether RBC deformability was affected in human or murine sepsis, a deformability index was determined in a human study and a murine model. Deformability was decreased postoperatively in patients with sepsis (0.49 +/- 0.12) compared with patients without sepsis (1.62 +/- 0.13) and normal control volunteers (1.51 +/- 0.17). Deformability was decreased in rats that had undergone cecal ligation and puncture (0.37 +/- 0.06) compared with that of sham-operated rats (0.76 +/- 0.12), as well as in endotoxemic rats (0.38 +/- 0.4) compared with control rats (0.82 +/- 0.11). These data suggest that RBC deformability decreases in both human and murine sepsis. This effect could be an important factor in the disordered oxygen utilization noted in human sepsis, and its correction could lead to better tissue oxygenation and preserved organ function.

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Year:  1988        PMID： 3277585     DOI： 10.1001/archsurg.1988.01400260101012

Source DB:  PubMed          Journal:  Arch Surg        ISSN： 0004-0010


  15 in total

Review 1.  The clinical importance of erythrocyte deformability, a hemorrheological parameter.

Authors:  F C Mokken; M Kedaria; C P Henny; M R Hardeman; A W Gelb
Journal:  Ann Hematol       Date:  1992-03       Impact factor: 3.673

Review 2.  Red blood cell transfusion in the neurological ICU.

Authors:  Monisha A Kumar
Journal:  Neurotherapeutics       Date:  2012-01       Impact factor: 7.620

Review 3.  Mechanisms of Hemolysis During Sepsis.

Authors:  Katharina Effenberger-Neidnicht; Matthias Hartmann
Journal:  Inflammation       Date:  2018-10       Impact factor: 4.092

4.  Group B Streptococcus impairs erythrocyte deformability in neonates more than in adults.

Authors:  J M Pöschl; P Ruef; M Schnauffer; S Pohl; H G Sonntag; O Linderkamp
Journal:  Arch Dis Child Fetal Neonatal Ed       Date:  1996-05       Impact factor: 5.747

5.  Testosterone depletion or blockade in male rats protects against trauma hemorrhagic shock-induced distant organ injury by limiting gut injury and subsequent production of biologically active mesenteric lymph.

Authors:  Sharvil U Sheth; David Palange; Da-Zhong Xu; Dong Wei; Eleonora Feketeova; Qi Lu; Diego C Reino; Xiaofa Qin; Edwin A Deitch
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6.  Factors influencing transcutaneous oxygen and carbon dioxide measurements in adult intensive care patients.

Authors:  W Hasibeder; M Haisjackl; H Sparr; S Klaunzer; C Hörman; N Salak; R Germann; W J Stronegger; J M Hackl
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Review 7.  Red blood cell rheology in sepsis.

Authors:  M Piagnerelli; K Zouaoui Boudjeltia; M Vanhaeverbeek; J-L Vincent
Journal:  Intensive Care Med       Date:  2003-06-12       Impact factor: 17.440

8.  The effect of red blood cell transfusion on tissue oxygenation and microcirculation in severe septic patients.

Authors:  Farid Sadaka; Ravi Aggu-Sher; Katie Krause; Jacklyn O'Brien; Eric S Armbrecht; Robert W Taylor
Journal:  Ann Intensive Care       Date:  2011-11-08       Impact factor: 6.925

Review 9.  Human malarial disease: a consequence of inflammatory cytokine release.

Authors:  Ian A Clark; Alison C Budd; Lisa M Alleva; William B Cowden
Journal:  Malar J       Date:  2006-10-10       Impact factor: 2.979

10.  Estrogenic hormone modulation abrogates changes in red blood cell deformability and neutrophil activation in trauma hemorrhagic shock.

Authors:  Danielle R Doucet; R Paul Bonitz; Rena Feinman; Iriana Colorado; Mahdury Ramanathan; Eleanora Feketeova; Michael Condon; George W Machiedo; Carl J Hauser; Da-Zhong Xu; Edwin A Deitch
Journal:  J Trauma       Date:  2010-01
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