Literature DB >> 3277535

Purification to homogeneity and some properties of squalene synthetase.

K Sasiak1, H C Rilling.   

Abstract

Squalene synthetase has been purified to homogeneity from yeast. It is a single polypeptide of Mr 47,000. This enzyme catalyzes the synthesis of squalene from farnesyl diphosphate via presqualene diphosphate. In the presence of reduced pyridine nucleotides, presqualene diphosphate and squalene are produced in a ratio of 6:1 from either the purified protein or the crude microsomal fraction.

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Year:  1988        PMID： 3277535     DOI： 10.1016/0003-9861(88)90490-0

Source DB:  PubMed          Journal:  Arch Biochem Biophys        ISSN： 0003-9861            Impact factor:   4.013


  13 in total

1.  Functional characterization and differential expression studies of squalene synthase from Withania somnifera.

Authors:  Neha Gupta; Poonam Sharma; R J Santosh Kumar; Rishi K Vishwakarma; B M Khan
Journal:  Mol Biol Rep       Date:  2012-06-21       Impact factor: 2.316

2.  Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii.

Authors:  Tom D Niehaus; Shigeru Okada; Timothy P Devarenne; David S Watt; Vitaliy Sviripa; Joe Chappell
Journal:  Proc Natl Acad Sci U S A       Date:  2011-07-11       Impact factor: 11.205

3.  Molecular cloning and characterization of the yeast gene for squalene synthetase.

Authors:  S M Jennings; Y H Tsay; T M Fisch; G W Robinson
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-15       Impact factor: 11.205

4.  Carotenoid biosynthesis: Isolation and characterization of a bifunctional enzyme catalyzing the synthesis of phytoene.

Authors:  O Dogbo; A Laferriére; A D'Harlingue; B Camara
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

5.  Purification and reactivation of recombinant Synechococcus phytoene desaturase from an overexpressing strain of Escherichia coli.

Authors:  P D Fraser; H Linden; G Sandmann
Journal:  Biochem J       Date:  1993-05-01       Impact factor: 3.857

6.  Expression, purification and properties of lycopene cyclase from Erwinia uredovora.

Authors:  G Schnurr; N Misawa; G Sandmann
Journal:  Biochem J       Date:  1996-05-01       Impact factor: 3.857

7.  Cloning, expression, and characterization of cDNAs encoding Arabidopsis thaliana squalene synthase.

Authors:  T Nakashima; T Inoue; A Oka; T Nishino; T Osumi; S Hata
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-14       Impact factor: 11.205

8.  Isolation and primary structure of the ERG9 gene of Saccharomyces cerevisiae encoding squalene synthetase.

Authors:  M Fegueur; L Richard; A D Charles; F Karst
Journal:  Curr Genet       Date:  1991-11       Impact factor: 3.886

9.  Conservation between human and fungal squalene synthetases: similarities in structure, function, and regulation.

Authors:  G W Robinson; Y H Tsay; B K Kienzle; C A Smith-Monroy; R W Bishop
Journal:  Mol Cell Biol       Date:  1993-05       Impact factor: 4.272

10.  Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase.

Authors:  J D Bergstrom; M M Kurtz; D J Rew; A M Amend; J D Karkas; R G Bostedor; V S Bansal; C Dufresne; F L VanMiddlesworth; O D Hensens
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-01       Impact factor: 11.205
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