Michał Żorniak1,2, Simon Sirtl1, Julia Mayerle1, Georg Beyer1. 1. Medical Department II, University Hospital, LMU Munich, Munich, Germany. 2. Department of Gastroenterology, Medical University of Silesia, Katowice, Poland.
Abstract
BACKGROUND: Alcoholic pancreatitis is a serious medical concern worldwide and remains to be one of the common causes of pancreatic disease. SUMMARY: While alcohol consumption causes direct damage to pancreatic tissue, only a small percentage of active drinkers will develop pancreatitis. An explanation of this phenomenon is probably that alcohol increases pancreatic vulnerability to damage; however, the simultaneous presence of additional risk factors and pancreatic costressors is required to increase the risk of pancreatitis and its complications caused by alcohol misuse. Recently, a number of important genetic as well as environmental factors influencing the risk of alcoholic pancreatitis have been described. KEY MESSAGES: In brief, this review reports established factors for the development of alcoholic pancreatitis and summarizes recent progress made in basic and clinical research.
BACKGROUND: Alcoholic pancreatitis is a serious medical concern worldwide and remains to be one of the common causes of pancreatic disease. SUMMARY: While alcohol consumption causes direct damage to pancreatic tissue, only a small percentage of active drinkers will develop pancreatitis. An explanation of this phenomenon is probably that alcohol increases pancreatic vulnerability to damage; however, the simultaneous presence of additional risk factors and pancreatic costressors is required to increase the risk of pancreatitis and its complications caused by alcohol misuse. Recently, a number of important genetic as well as environmental factors influencing the risk of alcoholic pancreatitis have been described. KEY MESSAGES: In brief, this review reports established factors for the development of alcoholic pancreatitis and summarizes recent progress made in basic and clinical research.
Authors: Cristiane de Oliveira; Biswajit Khatua; Pawan Noel; Sergiy Kostenko; Arup Bag; Bijinu Balakrishnan; Krutika S Patel; Andre A Guerra; Melissa N Martinez; Shubham Trivedi; Ann McCullough; Dora M Lam-Himlin; Sarah Navina; Douglas O Faigel; Norio Fukami; Rahul Pannala; Anna Evans Phillips; Georgios I Papachristou; Erin E Kershaw; Mark E Lowe; Vijay P Singh Journal: J Clin Invest Date: 2020-04-01 Impact factor: 14.808