Coexisting adenocarcinoma and malignant lymphoma of the stomach: case report and review of the Japanese literature.

After a diagnosis of advanced carcinoma, a 77-yr-old female underwent gastrectomy. A 6 X 5 cm ulcerative mass in the angle was shown to be differentiated adenocarcinoma in the surrounding wall, and malignant lymphoma in the bottom. Carcinomatous infiltration was limited to the muscularis mucosae. Neither generalized lymphoma nor locoregional lymph node metastasis of either neoplasm was noted. A survey of 35 Japanese patients, including our own case with the two coexistent neoplasms in the stomach, revealed that the male-to-female ratio was 2.3:1, with no significant difference between the mean age of the sexes. The prevalence of adenocarcinoma in its early stage (60% of 35 patients) and of a histologically differentiated type (85% of 27 patients) of adenocarcinoma is quite different from that of usual Japanese gastric carcinoma, and it may suggest that there are some factors influencing the coexistent development of both neoplasms.