BACKGROUND: Biologically naïve patients with inflammatory bowel disease treated with vedolizumab (VDZ) are largely underrepresented in real-world cohorts. A multi-centre, observational cohort study was performed on the effectiveness and safety of VDZ in biologically naïve subjects with Crohn's disease (CD) and ulcerative colitis (UC). METHODS: Data of consecutive biologically naïve patients with CD and UC treated with VDZ from July 2016 to December 2019 were extracted from the cohort of the Sicilian Network for Inflammatory Bowel Disease. RESULTS: A total of 172 consecutive patients (CD: N = 88; UC: N = 84; median age 66.0 years) were included, with a median follow-up of 58.8 weeks. After 14 weeks, a clinical response was reported in 68.2% of patients with CD and 67.9% of patients with UC treated with VDZ, including 45.5% patients in the CD group and 46.4% patients in the UC group who achieved steroid-free remission. After 52 weeks, a clinical response was reported in 77.4% of CD and in 73.8% of UC patients treated with VDZ, including 59.7% patients in the CD group and 60.7% patients in the UC group who achieved steroid-free remission. CONCLUSIONS: This study demonstrates the effectiveness and safety of VDZ as a first-line biological, particularly among elderly patients.
BACKGROUND: Biologically naïve patients with inflammatory bowel disease treated with vedolizumab (VDZ) are largely underrepresented in real-world cohorts. A multi-centre, observational cohort study was performed on the effectiveness and safety of VDZ in biologically naïve subjects with Crohn's disease (CD) and ulcerative colitis (UC). METHODS: Data of consecutive biologically naïve patients with CD and UC treated with VDZ from July 2016 to December 2019 were extracted from the cohort of the Sicilian Network for Inflammatory Bowel Disease. RESULTS: A total of 172 consecutive patients (CD: N = 88; UC: N = 84; median age 66.0 years) were included, with a median follow-up of 58.8 weeks. After 14 weeks, a clinical response was reported in 68.2% of patients with CD and 67.9% of patients with UC treated with VDZ, including 45.5% patients in the CD group and 46.4% patients in the UC group who achieved steroid-free remission. After 52 weeks, a clinical response was reported in 77.4% of CD and in 73.8% of UC patients treated with VDZ, including 59.7% patients in the CD group and 60.7% patients in the UC group who achieved steroid-free remission. CONCLUSIONS: This study demonstrates the effectiveness and safety of VDZ as a first-line biological, particularly among elderly patients.
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Authors: N Plevris; C S Chuah; R M Allen; I D Arnott; P N Brennan; S Chaudhary; A M D Churchhouse; S Din; E Donoghue; D R Gaya; M Groome; H M Jafferbhoy; P W Jenkinson; W L Lam; M Lyons; J C Macdonald; M MacMaster; C Mowat; G D Naismith; L F Potts; E Saffouri; J P Seenan; A Sengupta; P Shasi; D I Sutherland; J A Todd; J Veryan; A J M Watson; D A Watts; G R Jones; C W Lees Journal: J Crohns Colitis Date: 2019-09-19 Impact factor: 9.071
Authors: Emily E Vivio; Navya Kanuri; Joanna J Gilbertsen; Kelly Monroe; Neelendu Dey; Chien-Huan Chen; Alexandra M Gutierrez; Matthew A Ciorba Journal: J Crohns Colitis Date: 2015-12-17 Impact factor: 9.071
Authors: Fraser Cummings; Daniel R Gaya; Scott Levison; Sreedhar Subramanian; Glynn Owen; Anna Rathmell; Fiona Glen; Dirk Demuth; Simon Meadowcroft; Peter M Irving Journal: Medicine (Baltimore) Date: 2019-03 Impact factor: 1.889
Authors: Parambir S Dulai; Siddharth Singh; Xiaoqian Jiang; Farhad Peerani; Neeraj Narula; Khadija Chaudrey; Diana Whitehead; David Hudesman; Dana Lukin; Arun Swaminath; Eugenia Shmidt; Shuang Wang; Brigid S Boland; John T Chang; Sunanda Kane; Corey A Siegel; Edward V Loftus; William J Sandborn; Bruce E Sands; Jean-Frederic Colombel Journal: Am J Gastroenterol Date: 2016-06-14 Impact factor: 12.045
Authors: Vince B C Biemans; C Janneke van der Woude; Gerard Dijkstra; Andrea E van der Meulen-de Jong; Bas Oldenburg; Nanne K de Boer; Mark Löwenberg; Nidhi Srivastava; Alexander G L Bodelier; Rachel L West; Jeroen M Jansen; Annemarie C de Vries; Jeoffrey J L Haans; Dirk J de Jong; Marie J Pierik; Frank Hoentjen Journal: Clin Pharmacol Ther Date: 2019-12-11 Impact factor: 6.875
Authors: Carl Eriksson; Sara Rundquist; Vyron Lykiardopoulos; Ruzan Udumyan; Per Karlén; Olof Grip; Charlotte Söderman; Sven Almer; Erik Hertervig; Jan Marsal; Jenny Gunnarsson; Carolina Malmgren; Jenny Delin; Hans Strid; Mats Sjöberg; David Öberg; Daniel Bergemalm; Henrik Hjortswang; Jonas Halfvarson Journal: Therap Adv Gastroenterol Date: 2021-07-03 Impact factor: 4.409