Masami Ando1,2, Yuki Nakao2, Ge Jin3, Hiroshi Sugiyama1, Naoki Sunaguchi4, Yongjin Sung5, Yoshifumi Suzuki3, Yong Sun3, Michio Tanimoto6, Katsuhiro Kawashima7, Tetsuya Yuasa8, Kensaku Mori9, Shu Ichihara10, Rajiv Gupta11. 1. Photon Factory, KEK, Oho 1-1, Tsukuba, Ibaraki, 305-0801, Japan. 2. Research Institute of Science and Engineering, Tokyo University of Science, Noda, Chiba, 278-8510, Japan. 3. Graduate School of Engineering, Kyushu Institute of Technology, Kitakyushu, 804-8550, Japan. 4. Graduate School of Medicine, Nagoya University, 1-1-20 Daiko-Minami, Higashi-Ku, Nagoya, Aichi, 461-8673, Japan. 5. University of Wisconsin, Milwaukee, WI, 53211, USA. 6. Shingijutsu Kyokai (Society of New Technology), Yushima, Bunkyo, Tokyo, 113-0034, Japan. 7. University of Technology, Katakura 1404-1, Hachioji, Tokyo, 192-0914, Japan. 8. Graduate School of Engineering and Science, Yamagata University, 4-3-16 Jyonan, Yonezawa, Yamagata, 992-8510, Japan. 9. Department of Media Science, Graduate School of Information Science, Nagoya University, Nagoya, Aichi, 464-8601, Japan. 10. Clinical Research Center, Department of Pathology, Nagoya Medical Center, Nagoya, Aichi, 460-0001, Japan. 11. Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 01778, USA.
Abstract
PURPOSE: This paper describes and experimentally validates a methodology for improving contrast and spatial resolution of the x-ray dark-field imaging (XDFI) by cutting the monochromator-collimator asymmetrically and thinning the Laue angle analyzer. METHODS: We measure the spatial resolution of our XDFI setup using a test object consisting of wolfram tungsten meshes and compare it with the theoretical prediction. Using x-ray dark-field computed tomography of breast cancer specimens (lobular carcinoma in situ), we demonstrate that the resolution of XDFI is sufficient for histopathologic analysis. RESULTS: Our experimental results show that the overall spatial resolution of XDFI can be improved by approximately a factor of 2 when these modifications are implemented. The reconstructed images of breast cancer specimens provide sufficient details for radiologic histopathology. CONCLUSIONS: By cutting the monochromator-collimator and thinning the Laue angle analyzer, XDFI can achieve the resolution sufficient for radiologic histopathology.
PURPOSE: This paper describes and experimentally validates a methodology for improving contrast and spatial resolution of the x-ray dark-field imaging (XDFI) by cutting the monochromator-collimator asymmetrically and thinning the Laue angle analyzer. METHODS: We measure the spatial resolution of our XDFI setup using a test object consisting of wolfram tungsten meshes and compare it with the theoretical prediction. Using x-ray dark-field computed tomography of breast cancer specimens (lobular carcinoma in situ), we demonstrate that the resolution of XDFI is sufficient for histopathologic analysis. RESULTS: Our experimental results show that the overall spatial resolution of XDFI can be improved by approximately a factor of 2 when these modifications are implemented. The reconstructed images of breast cancer specimens provide sufficient details for radiologic histopathology. CONCLUSIONS: By cutting the monochromator-collimator and thinning the Laue angle analyzer, XDFI can achieve the resolution sufficient for radiologic histopathology.
Authors: Samantha J Alloo; David M Paganin; Kaye S Morgan; Marcus J Kitchen; Andrew W Stevenson; Sheridan C Mayo; Heyang T Li; Ben M Kennedy; Anton Maksimenko; Joshua C Bowden; Konstantin M Pavlov Journal: J Med Imaging (Bellingham) Date: 2022-02-07