K Dhanalakshmi1, Aishwarya Venkataraman2, S Balasubramanian1, Manoj Madhusudan1, Sumanth Amperayani1, Sulochana Putilibai3, Kalaimaran Sadasivam4, Bala Ramachandran5, A V Ramanan6. 1. Department of Paediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India. 2. Department of Paediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India. Correspondence to: Dr Aishwarya Venkataraman, Department of Paediatrics, Kanchi Kamakoti CHILDS Trust Hospital, 12A Nageswara Road, Nungambakkam, Chennai 600 034, India. draishwaryav@gmail.com. 3. Department of Microbiology, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India. 4. Department of Paediatric Intensive Care Unit, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu. 5. Department of Paediatric Intensive Care Unit, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India. 6. Bristol Royal Hospital for Children, Bristol, United Kingdom.
Abstract
Background: We describe the demographic, clinical and labo-ratory findings along with the treatment and outcomes among children meeting the case definition of Pediatric Inflammatory Multisystem Syndrome - Temporally associated with SARS-CoV-2 (PIMS-TS). METHODS: We analyzed the clinical and laboratory findings of children who presented with PIMS-TS during an 8-week period from May 4, 2020 to July 8, 2020. RESULTS: We report 19 children with a median age of 6 year (IQR: 13 months-16 years), who met the case definition of PIMS-TS. All of them presented with fever. Multi organ involvement (79%), mucocutaneous involvement (74%), cardiovascular symptoms (63%) and gastrointestinal symptoms (42%) were the other features. Elevated levels of C-reactive protein was found in all of them and the majority of them had evidence of coagulopathy; intensive care admissions were needed in 12 (63%) and vasoactive medications were given to 6 (31.5%) children. There were no deaths. CONCLUSION: Children with PIMS-TS present with a wide range of signs and symptoms. Fewer children in this series had coronary artery abnormalities, and there was a low incidence of RT-PCR positivity with high presence of SARS-CoV-2 antibodies.
Background: We describe the demographic, clinical and labo-ratory findings along with the treatment and outcomes among children meeting the case definition of Pediatric Inflammatory Multisystem Syndrome - Temporally associated with SARS-CoV-2 (PIMS-TS). METHODS: We analyzed the clinical and laboratory findings of children who presented with PIMS-TS during an 8-week period from May 4, 2020 to July 8, 2020. RESULTS: We report 19 children with a median age of 6 year (IQR: 13 months-16 years), who met the case definition of PIMS-TS. All of them presented with fever. Multi organ involvement (79%), mucocutaneous involvement (74%), cardiovascular symptoms (63%) and gastrointestinal symptoms (42%) were the other features. Elevated levels of C-reactive protein was found in all of them and the majority of them had evidence of coagulopathy; intensive care admissions were needed in 12 (63%) and vasoactive medications were given to 6 (31.5%) children. There were no deaths. CONCLUSION:Children with PIMS-TS present with a wide range of signs and symptoms. Fewer children in this series had coronary artery abnormalities, and there was a low incidence of RT-PCR positivity with high presence of SARS-CoV-2 antibodies.
Authors: Marta Cabrero-Hernández; Alberto García-Salido; Inés Leoz-Gordillo; Jose Antonio Alonso-Cadenas; Ainhoa Gochi-Valdovinos; Anthony González Brabin; Gema De Lama Caro-Patón; Montserrat Nieto-Moro; Amelia Martínez- de-Azagra-Garde; Ana Serrano-González Journal: Pediatr Infect Dis J Date: 2020-08 Impact factor: 2.129
Authors: Leora R Feldstein; Erica B Rose; Steven M Horwitz; Jennifer P Collins; Margaret M Newhams; Mary Beth F Son; Jane W Newburger; Lawrence C Kleinman; Sabrina M Heidemann; Amarilis A Martin; Aalok R Singh; Simon Li; Keiko M Tarquinio; Preeti Jaggi; Matthew E Oster; Sheemon P Zackai; Jennifer Gillen; Adam J Ratner; Rowan F Walsh; Julie C Fitzgerald; Michael A Keenaghan; Hussam Alharash; Sule Doymaz; Katharine N Clouser; John S Giuliano; Anjali Gupta; Robert M Parker; Aline B Maddux; Vinod Havalad; Stacy Ramsingh; Hulya Bukulmez; Tamara T Bradford; Lincoln S Smith; Mark W Tenforde; Christopher L Carroll; Becky J Riggs; Shira J Gertz; Ariel Daube; Amanda Lansell; Alvaro Coronado Munoz; Charlotte V Hobbs; Kimberly L Marohn; Natasha B Halasa; Manish M Patel; Adrienne G Randolph Journal: N Engl J Med Date: 2020-06-29 Impact factor: 91.245
Authors: Elizabeth M Dufort; Emilia H Koumans; Eric J Chow; Elizabeth M Rosenthal; Alison Muse; Jemma Rowlands; Meredith A Barranco; Angela M Maxted; Eli S Rosenberg; Delia Easton; Tomoko Udo; Jessica Kumar; Wendy Pulver; Lou Smith; Brad Hutton; Debra Blog; Howard Zucker Journal: N Engl J Med Date: 2020-06-29 Impact factor: 91.245
Authors: Patrick Davies; Claire Evans; Hari Krishnan Kanthimathinathan; Jon Lillie; Joseph Brierley; Gareth Waters; Mae Johnson; Benedict Griffiths; Pascale du Pré; Zoha Mohammad; Akash Deep; Stephen Playfor; Davinder Singh; David Inwald; Michelle Jardine; Oliver Ross; Nayan Shetty; Mark Worrall; Ruchi Sinha; Ashwani Koul; Elizabeth Whittaker; Harish Vyas; Barnaby R Scholefield; Padmanabhan Ramnarayan Journal: Lancet Child Adolesc Health Date: 2020-07-09
Authors: Elizabeth Whittaker; Alasdair Bamford; Julia Kenny; Myrsini Kaforou; Christine E Jones; Priyen Shah; Padmanabhan Ramnarayan; Alain Fraisse; Owen Miller; Patrick Davies; Filip Kucera; Joe Brierley; Marilyn McDougall; Michael Carter; Adriana Tremoulet; Chisato Shimizu; Jethro Herberg; Jane C Burns; Hermione Lyall; Michael Levin Journal: JAMA Date: 2020-07-21 Impact factor: 157.335
Authors: M M Melo; M M R Neta; A R S Neto; A R B Carvalho; R L B Magalhães; A R M C Valle; J H L Ferreira; K M J Aliaga; M E B Moura; D R J Freitas Journal: Braz J Med Biol Res Date: 2022-06-13 Impact factor: 2.904
Authors: Jessica Flood; Joseph Shingleton; Emma Bennett; Brodie Walker; Zahin Amin-Chowdhury; Godwin Oligbu; Jacob Avis; Richard M Lynn; Peter Davis; Tara Bharucha; Clare E Pain; Deepthi Jyothish; Elizabeth Whittaker; Buvana Dwarakanathan; Rachael Wood; Christopher Williams; Olivia Swann; Malcolm G Semple; Mary E Ramsay; Christine E Jones; Athimalaipet V Ramanan; Nick Gent; Shamez N Ladhani Journal: Lancet Reg Health Eur Date: 2021-03-22